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  1. We have reviewed the impact of the ubiquitin proteasome system (UPS) on atherosclerosis progression of diabetic patients. A puzzle of many pieces of evidence suggests that UPS, in addition to its role in the r...

    Authors: Raffaele Marfella, Michele D' Amico, Clara Di Filippo, Mario Siniscalchi, Ferdinando Carlo sasso, Franca Ferraraccio, Francesco Rossi and Giuseppe Paolisso
    Citation: Cardiovascular Diabetology 2007 6:35
    Content type: Hypothesis Published on:

  2. Congenital heart defects are frequently observed in infants of diabetic mothers, but the molecular basis of the defects remains obscure. Thus, the present study was performed to gain some insights into the mol...

    Authors: Srinivasan Dinesh Kumar, S Thameem Dheen and Samuel Sam Wah Tay
    Citation: Cardiovascular Diabetology 2007 6:34
    Content type: Original investigation Published on:

  3. Inhibition of vascular smooth muscle cell (vSMC) proliferation by oral anti-hyperglycemic agents may have a role to play in the amelioration of vascular disease in diabetes. Thiazolidinediones (TZDs) inhibit v...

    Authors: Peter J Little, Narin Osman, Stephanie T de Dios, Nelly Cemerlang, Mandy Ballinger and Julie Nigro
    Citation: Cardiovascular Diabetology 2007 6:33
    Content type: Original investigation Published on:

  4. Impaired glucose regulation (IGR) is associated with detrimental cardiovascular outcomes such as cardiovascular disease risk factors (CVD risk factors) or intima-media thickness (IMT). Our aim was to examine w...

    Authors: David Faeh, Julita William, Patrick Yerly, Fred Paccaud and Pascal Bovet
    Citation: Cardiovascular Diabetology 2007 6:32
    Content type: Original investigation Published on:

  5. Because of previously reported ethnic differences in determinants and markers of obesity and related metabolic disorders, we sought to investigate circulating levels of adiponectin and their correlates in a su...

    Authors: Eugène Sobngwi, Valery Effoe, Philippe Boudou, Dieudonné Njamen, Jean-François Gautier and Jean-Claude Mbanya
    Citation: Cardiovascular Diabetology 2007 6:31
    Content type: Original investigation Published on:

  6. Recent studies have suggested that diabetes mellitus (DM) may cause left ventricular (LV) dysfunction directly resulting in increased susceptibility to heart failure. Using pinhole collimators and advances in ...

    Authors: Bernard Cosyns, Steven Droogmans, Caroline Weytjens, Tony Lahoutte, Guy Van Camp, Danny Schoors and Philippe R Franken
    Citation: Cardiovascular Diabetology 2007 6:30
    Content type: Original investigation Published on:

  7. Women with PCOS have been reported to be at increased risk of a number of gynaecological neoplasias, including endometrial, breast, and ovarian cancer. Studies of the possible association of genetic variation ...

    Authors: Muammer Karadeniz, Mehmet Erdogan, Afig Berdeli, Sadik Tamsel, Fusun Saygili and Candeger Yilmaz
    Citation: Cardiovascular Diabetology 2007 6:29
    Content type: Original investigation Published on:

  8. The Study of Micardis (telmisartan) in Overweight/Obese patients with Type 2 diabetes and Hypertension (SMOOTH) compared hydrochlorothiazide (HCTZ) plus telmisartan or valsartan fixed-dose combination therapie...

    Authors: Arya M Sharma, Jaime Davidson, Stephen Koval and Yves Lacourcière
    Citation: Cardiovascular Diabetology 2007 6:28
    Content type: Original investigation Published on:

  9. Since visceral fat tissue is known to release various inflammatory and anti-inflammatory cytokines, abdominal obesity may play a key role in the inflammation associated with metabolic syndrome (MetS). However,...

    Authors: Makoto Nishida, Toshiki Moriyama, Yoshiro Sugita and Keiko Yamauchi-Takihara
    Citation: Cardiovascular Diabetology 2007 6:27
    Content type: Original investigation Published on:

  10. A beneficial effect on glucose metabolism is reported with angiotensin receptor blocker (ARB) treatment of hypertension. The effect on blood glucose level during the course of treatment with ARBs in clinical c...

    Authors: Noboru Kitamura, Yasuo Takahashi, Shuukoh Yamadate and Satoshi Asai
    Citation: Cardiovascular Diabetology 2007 6:26
    Content type: Original investigation Published on:

  11. Lack of treatment initiation or intensification might explain why some patients with type 2 diabetes do not reach target goals. The objective is to assess trends in risk factor treatment, and identify determin...

    Authors: Jacoba P Greving, Petra Denig, Dick de Zeeuw, Henk JG Bilo and Flora M Haaijer-Ruskamp
    Citation: Cardiovascular Diabetology 2007 6:25
    Content type: Original investigation Published on:

  12. Diabetes Mellitus (DM) is a major public health problem in the UAE with a prevalence rate reaching 24% in national citizens and 17.4% in expatriates. The aim of this study was to determine the prevalence and r...

    Authors: Fatma Al-Maskari, Mohammed El-Sadig and John N Norman
    Citation: Cardiovascular Diabetology 2007 6:24
    Content type: Original investigation Published on:

  13. Although oxidative stress by accumulation of reactive oxygen species (ROS) in diabetes has become evident, it remains unclear what genes, involved in redox balance, would determine susceptibility for developme...

    Authors: Masami Nemoto, Rimei Nishimura, Takashi Sasaki, Yoshito Hiki, Yumi Miyashita, Makiko Nishioka, Kei Fujimoto, Toru Sakuma, Toya Ohashi, Kunihiko Fukuda, Yoshikatsu Eto and Naoko Tajima
    Citation: Cardiovascular Diabetology 2007 6:23
    Content type: Original investigation Published on:

  14. The metabolic syndrome (MetSyn) places individuals at increased risk for type 2 diabetes and cardiovascular disease. Prevalence rates of the population of the MetSyn are still scarce. Moreover, the impact of d...

    Authors: Susanne Moebus, Jens Ulrich Hanisch, Pamela Aidelsburger, Peter Bramlage, Jürgen Wasem and Karl-Heinz Jöckel
    Citation: Cardiovascular Diabetology 2007 6:22
    Content type: Original investigation Published on:

  15. Type 2 diabetes is characterised by increased plasma concentrations of pro-inflammatory cytokines [such as tumour necrosis factor – alpha; TNF-α] and soluble forms of adhesion molecules involved in leukocyte –...

    Authors: Joanna R Worley, David A Hughes, Nicoletta Dozio, Jelena Gavrilovic and Mike J Sampson
    Citation: Cardiovascular Diabetology 2007 6:21
    Content type: Original investigation Published on:

  17. The association between TGF-β1 levels and long-term major adverse cardiovascular events (MACE) in patients with coronary artery disease (CAD) is controversial. No study specifically addressed patients with CAD...

    Authors: Beatriz D Schaan, Alexandre S Quadros, Rogério Sarmento-Leite, Giuseppe De Lucca Jr, Alexandra Bender and Marcello Bertoluci
    Citation: Cardiovascular Diabetology 2007 6:19
    Content type: Original investigation Published on:

  18. Little information is available on leptin concentrations in individuals with IGT. This study aims to determine and correlate leptin levels to anthropometric measures of obesity in pre-diabetic, (IFG and IGT), ...

    Authors: Nasser M Al-Daghri, Omar S Al-Attas, Khalid Al-Rubeaan, Mehad Mohieldin, Mohammad Al-Katari, Alan F Jones and Sudhesh Kumar
    Citation: Cardiovascular Diabetology 2007 6:18
    Content type: Original investigation Published on:

  19. Sensitivity to ischemia and its underlying mechanisms in type 2 diabetic hearts are still largely unknown. Especially, correlation between reperfusion induced ventricular arrhythmia and changes in intracellula...

    Authors: Ryuko Anzawa, Shingo Seki, Kazuaki Horikoshi, Masayuki Taniguchi and Seibu Mochizuki
    Citation: Cardiovascular Diabetology 2007 6:17
    Content type: Original investigation Published on:

  20. Observational clinical studies have shown that patients with diabetes have less favorable results after percutaneous coronary intervention compared with the non-diabetic counterparts, but its mechanism remains...

    Authors: Qi Zhang, Lin Lu, LiJin Pu, RuiYan Zhang, Jie Shen, ZhengBing Zhu, Jian Hu, ZhenKun Yang, QiuJin Chen and WeiFeng Shen
    Citation: Cardiovascular Diabetology 2007 6:16
    Content type: Original investigation Published on:

  21. The atheroprotective effects of systemic delivery of either apolipoprotein A-I (wtApoA-I) or the naturally occurring mutant ApoA-I Milano (ApoA-IM) have been established in animal and human trials, but direct com...

    Authors: Corinna Lebherz, Julio Sanmiguel, James M Wilson and Daniel J Rader
    Citation: Cardiovascular Diabetology 2007 6:15
    Content type: Original investigation Published on:

  22. Because cardiomyopathy is the leading cause of death in diabetic patients, the determination of myocardial function in diabetes mellitus is essential. In the present study, we provide an integrated approach, u...

    Authors: Rogério Wichi, Christiane Malfitano, Kaleizu Rosa, Silvia B De Souza, Vera Salemi, Cristiano Mostarda, Kátia De Angelis and Maria Claudia Irigoyen
    Citation: Cardiovascular Diabetology 2007 6:14
    Content type: Original investigation Published on:

  23. One of the major controversies surrounding the metabolic syndrome (MetS) in type 2 diabetes is whether its single components act synergistically as risk factors for atherosclerotic vascular disease (AVD). We a...

    Authors: Markolf Hanefeld, Carsta Koehler, Silvina Gallo, Inge Benke and Petra Ott
    Citation: Cardiovascular Diabetology 2007 6:13
    Content type: Original investigation Published on:

  24. The metabolic syndrome is a cluster of cardiovascular risk factors leading to an increased risk for the subsequent development of diabetes and cardiovascular morbidity and mortality. Blocking the renin-angiote...

    Authors: Ulrich Kintscher, Peter Bramlage, W Dieter Paar, Martin Thoenes and Thomas Unger
    Citation: Cardiovascular Diabetology 2007 6:12
    Content type: Original investigation Published on:

  25. Low income individuals with diabetes are at particularly high risk for poor health outcomes. While specialized diabetes care may help reduce this risk, it is not currently known whether there are significant c...

    Authors: Doreen M Rabi, Alun L Edwards, Lawrence W Svenson, Peter M Sargious, Peter Norton, Erik T Larsen and William A Ghali
    Citation: Cardiovascular Diabetology 2007 6:11
    Content type: Original investigation Published on:

  26. Immigrant women from the Middle East have elevated risk of cardiovascular disease. Sagittal abdominal diameter (SAD), a simple marker of intra-abdominal fat, predicts insulin resistance and cardiovascular mort...

    Authors: Helena Petersson, Achraf Daryani and Ulf Risérus
    Citation: Cardiovascular Diabetology 2007 6:10
    Content type: Original investigation Published on:

  27. Total circulating soluble receptor for advanced glycation endproducts (sRAGE) and a more defined endogenous secretory splice variant of the receptor (esRAGE) were shown to be associated with different markers ...

    Authors: Per M Humpert, Zdenka Djuric, Stefan Kopf, Gottfried Rudofsky, Michael Morcos, Peter P Nawroth and Angelika Bierhaus
    Citation: Cardiovascular Diabetology 2007 6:9
    Content type: Original investigation Published on:

  28. As a part of a larger study investigating the effects of α-tocopherol on gene expression in type 2 diabetics we observed a pro-oxidant effect of α-tocopherol which we believe may be useful in interpreting outc...

    Authors: Mark S Winterbone, Mike J Sampson, Shikha Saha, Jackie C Hughes and David A Hughes
    Citation: Cardiovascular Diabetology 2007 6:8
    Content type: Original investigation Published on:

  29. Adipose tissue secreted proteins are collectively named adipocytokines and include leptin, adiponectin, resistin, collagenous repeat-containing sequence of 26-kDa protein (CORS-26) and omentin. Several of thes...

    Authors: Sylvia Wurm, Markus Neumeier, Johanna Weigert, Andreas Schäffler and Christa Buechler
    Citation: Cardiovascular Diabetology 2007 6:7
    Content type: Original investigation Published on:

  30. Diabetes is associated with a cardiomyopathy that is independent of coronary artery disease or hypertension. In the present study we used in vivo magnetic resonance imaging (MRI) and echocardiographic techniqu...

    Authors: Xichun Yu, Yasvir A Tesiram, Rheal A Towner, Andrew Abbott, Eugene Patterson, Shijun Huang, Marion W Garrett, Suresh Chandrasekaran, Satoshi Matsuzaki, Luke I Szweda, Brian E Gordon and David C Kem
    Citation: Cardiovascular Diabetology 2007 6:6
    Content type: Original investigation Published on:

  31. Diabetes mellitus is a growing public health problem, for which efficient and timely surveillance is a key policy. Administrative databases offer relevant opportunities for this purpose. We aim to monitor the ...

    Authors: Stefano Brocco, Cristiana Visentin, Ugo Fedeli, Elena Schievano, Angelo Avogaro, Margherita Andretta, Francesco Avossa and Paolo Spolaore
    Citation: Cardiovascular Diabetology 2007 6:5
    Content type: Original investigation Published on:

  32. The rising prevalence of obesity and metabolic syndrome (MetS) has received increased attention since both place individuals at risk for Type II diabetes and cardiovascular disease. Insulin resistance (IR) has...

    Authors: Sarita Dhuper, Hillel W Cohen, Josephine Daniel, Padmasree Gumidyala, Vipin Agarwalla, Rosemarie St Victor and Sunil Dhuper
    Citation: Cardiovascular Diabetology 2007 6:4
    Content type: Original investigation Published on:

  33. The omental adipose tissue is pathogenetically involved in both type 2 diabetes mellitus (T2D) and chronic inflammatory bowel diseases (IBD) such as Ulcerative colitis (UC) and Crohn's Disease (CD). Thus, adip...

    Authors: Andreas Schäffler, Martina Zeitoun, Hella Wobser, Christa Buechler, Charalampos Aslanidis and Hans Herfarth
    Citation: Cardiovascular Diabetology 2007 6:3
    Content type: Original investigation Published on:

  34. Elevated blood glucose values are a prognostic factor in myocardial infarction (MI) patients. The unfavourable relation between hyperglycemia and outcome is known for admission glucose and fasting glucose afte...

    Authors: Iwan CC van der Horst, Maarten WN Nijsten, Mathijs Vogelzang and Felix Zijlstra
    Citation: Cardiovascular Diabetology 2007 6:2
    Content type: Original investigation Published on:

  35. The high glucose levels typically occurring among adults with type 2 diabetes contribute to blood vessel injury and complications such as blindness, kidney failure, heart disease, and stroke. Higher physical a...

    Authors: Kaberi Dasgupta, Cathy Chan, Deborah Da Costa, Louise Pilote, Mirella De Civita, Nancy Ross, Ian Strachan, Ronald Sigal and Lawrence Joseph
    Citation: Cardiovascular Diabetology 2007 6:1
    Content type: Study protocol Published on:

  36. Coronary artery disease (CAD) is a major vascular complication of diabetes mellitus and reveals high mortality. Up to 30% of diabetic patients with myocardial ischemia remain asymptomatic and are associated wi...

    Authors: Li Jin Pu, Lin Lu, Xue Wei Xu, Rui Yan Zhang, Qi Zhang, Jian Sheng Zhang, Jian Hu, Zheng Kun Yang, Feng Hua Ding, Qiu Jin Chen, Sheng Lou, Jie Shen, Dan Hong Fang and Wei Feng Shen
    Citation: Cardiovascular Diabetology 2006 5:27
    Content type: Original investigation Published on:

  37. In spite of a large amount of studies in anesthetized animals, isolated hearts, and in vitro cardiomyocytes, to our knowledge, myocardial function was never studied in conscious diabetic rats. Myocardial perfo...

    Authors: Giulianna R Borges, Mauro de Oliveira, Helio C Salgado and Rubens Fazan Jr
    Citation: Cardiovascular Diabetology 2006 5:26
    Content type: Original investigation Published on:

  38. The metabolic syndrome together with insulin resistance and their consequences are basic factors in pathogenesis of atherosclerosis. Chronic infections with herpes simplex virus type 1 (HSV-1), cytomegalovirus...

    Authors: Iraj Nabipour, Katayon Vahdat, Seyed Mojtaba Jafari, Raha Pazoki and Zahra Sanjdideh
    Citation: Cardiovascular Diabetology 2006 5:25
    Content type: Original investigation Published on:

  40. Target organ damage (mainly cardiac and renal damage) is easy to evaluate in outpatient clinics and offers valuable information about patient's cardiovascular risk. The purpose of this study was to evaluate, u...

    Authors: Luis Cea-Calvo, Pedro Conthe, Pablo Gómez-Fernández, Fernando de Alvaro and Cristina Fernández-Pérez
    Citation: Cardiovascular Diabetology 2006 5:23
    Content type: Original investigation Published on:

  41. Obstructive sleep apnoea (OSA) is a cardio-metabolic disorder. Whether metabolic syndrome (MS), insulin resistance (IR) and albuminuria are independently associated with OSA is unclear, but defining the intera...

    Authors: A Gruber, F Horwood, J Sithole, NJ Ali and I Idris
    Citation: Cardiovascular Diabetology 2006 5:22
    Content type: Original investigation Published on:

  42. Patients with diabetes already fulfill one diagnostic criterion for MS according to the existing classifications. Our aim was to identify one single clinical parameter, which could effectively predict the pres...

    Authors: Maria Kompoti, Anargiros Mariolis, Alevizos Alevizos, Ioannis Kyriazis, Ioannis Protopsaltis, Eleni Dimou, Ioannis Lentzas, Dimitrios Levisianou, Afroditi Gova and Andreas Melidonis
    Citation: Cardiovascular Diabetology 2006 5:21
    Content type: Methodology Published on:

  43. Lowering of low-density lipoprotein cholesterol with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) is clearly efficacious in the treatment and prevention of coronary artery disease. Howe...

    Authors: Alexander Tenenbaum, Enrique Z Fisman, Michael Motro and Yehuda Adler
    Citation: Cardiovascular Diabetology 2006 5:20
    Content type: Review Published on:

  44. The aim of this study was to determine if hypertensive type 2 diabetic patients, when compared to patients with essential hypertension have an increased left ventricular mass index (LVMI) and a worse diastolic...

    Authors: João S Felício, Juliana T Pacheco, Sandra R Ferreira, Frida Plavnik, Valdir A Moisés, Oswaldo Kohlmann Jr, Artur B Ribeiro and Maria T Zanella
    Citation: Cardiovascular Diabetology 2006 5:19
    Content type: Original investigation Published on:

  45. Diabetes mellitus is an important risk factor for increased vein graft failure after bypass surgery. However, the cellular and molecular mechanism(s) underlying vessel attrition in this population remain large...

    Authors: Kevin M Rice, Devashish H Desai, Sunil K Kakarla, Anjaiah Katta, Deborah L Preston, Paulette Wehner and Eric R Blough
    Citation: Cardiovascular Diabetology 2006 5:18
    Content type: Original investigation Published on:

  46. Systemic adiponectin is reduced in patients with cardiovascular disease (CVD) and low adiponectin may contribute to the pathogenesis of atherosclerosis. However, circulating adiponectin is elevated in type 1 d...

    Authors: Sabine Abke, Markus Neumeier, Johanna Weigert, Gabriele Wehrwein, Elke Eggenhofer, Andreas Schäffler, Kevin Maier, Charalampos Aslanidis, Jürgen Schölmerich and Christa Buechler
    Citation: Cardiovascular Diabetology 2006 5:17
    Content type: Original investigation Published on:

  47. Secondary treatment of arteriosclerosis may be applicable for the primary prevention of atherosclerosis in diabetic patients. This prospective, 2-year follow-up study was designed to determine the efficacy and...

    Authors: Yoshimitsu Yamasaki, Young-Seol Kim and Ryuzo Kawamori
    Citation: Cardiovascular Diabetology 2006 5:16
    Content type: Methodology Published on:

  48. Coronary artery disease is the leading cause of death in industrialized countries and most patients with diabetes die from complications of atherosclerosis. The objective of this study was to determine the pre...

    Authors: Alireza Esteghamati, Mehrshad Abbasi, Manouchehr Nakhjavani, Abbas Yousefizadeh, Amelita P Basa and Hamid Afshar
    Citation: Cardiovascular Diabetology 2006 5:15
    Content type: Original investigation Published on:

  49. Tumor necrosis factor-α (TNFα) is a mediator of insulin resistance. Plasma levels of soluble TNFα receptors (sTNFR1 and sTNFR2) probably reflect paracrine action of the cytokine. TNFα is also a regulator of li...

    Authors: Marek Straczkowski, Irina Kowalska, Agnieszka Nikolajuk, Agnieszka Adamska, Malgorzata Karolczuk-Zarachowicz, Monika Karczewska-Kupczewska, Agnieszka Kozlowska and Maria Gorska
    Citation: Cardiovascular Diabetology 2006 5:14
    Content type: Original investigation Published on:

  50. Foam cell formation in diabetic patients often occurs in the presence of high insulin and glucose levels. To test whether hyperinsulinemic hyperglycemic conditions affect foam cell differentiation, we examined...

    Authors: Pavel N Shashkin, Nitin Jain, Yury I Miller, Benjamin A Rissing, Yuqing Huo, Susanna R Keller, George E Vandenhoff, Jerry L Nadler and Thomas M McIntyre
    Citation: Cardiovascular Diabetology 2006 5:13
    Content type: Original investigation Published on:
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Cardiovascular Diabetology

ISSN: 1475-2840