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  1. Diabetes accelerates atherosclerosis through undefined molecular mechanisms. Hyperglycemia induces formation of advanced glycation end product (AGE)-modified low-density lipoprotein (LDL). Anti-AGE-LDL autoant...

    Authors: Lin Zhu, Zhiqing He, Feng Wu, Ru Ding, Qixia Jiang, Jiayou Zhang, Min Fan, Xing Wang, Bengtsson Eva, Nilsson Jan, Chun Liang and Zonggui Wu
    Citation: Cardiovascular Diabetology 2014 13:151
    Content type: Original investigation Published on:

  2. Peroxisome proliferator-activated receptor-γ (PPARγ) agonists, which have been used as insulin sensitizers in diabetic patients, may improve functions of endothelial cells (ECs). We investigated the effect of ...

    Authors: Jerzy Kotlinowski, Anna Grochot-Przeczek, Hevidar Taha, Magdalena Kozakowska, Bartosz Pilecki, Klaudia Skrzypek, Aleksandra Bartelik, Rafal Derlacz, Anton J G Horrevoets, Attila Pap, Laszlo Nagy, Jozef Dulak and Alicja Jozkowicz
    Citation: Cardiovascular Diabetology 2014 13:150
    Content type: Original investigation Published on:

    The Erratum to this article has been published in Cardiovascular Diabetology 2015 14:65

  3. Pre-diabetes and untreated diabetes are common in patients with peripheral artery disease however their impact on outcome has not been evaluated. We examined the association of impaired fasting glucose, diabet...

    Authors: Jonathan Golledge, Frank Quigley, Ramesh Velu, Phillip J Walker and Joseph V Moxon
    Citation: Cardiovascular Diabetology 2014 13:147
    Content type: Original investigation Published on:

  4. Recent evidence demonstrated that the circulating adipokines were associated with the onset of acute coronary syndrome (ACS) including unstable angina pectoris (UAP) and acute myocardial infarction (AMI). As a...

    Authors: Qingwei Ji, Yingzhong Lin, Zhishan Liang, Kunwu Yu, Yuyang Liu, Zhe Fang, Ling Liu, Ying Shi, Qiutang Zeng, Chao Chang, Meng Chai and Yujie Zhou
    Citation: Cardiovascular Diabetology 2014 13:145
    Content type: Original investigation Published on:

  5. Evidence has demonstrated that central fat distribution produces the most profound metabolic abnormalities and is associated with an increased risk of atherosclerotic cardiovascular diseases. We aimed to inves...

    Authors: Chenxi Ren, Jie Zhang, Yu Xu, Baihui Xu, Wanwan Sun, Jichao Sun, Tiange Wang, Min Xu, Jieli Lu, Weiqing Wang, Yufang Bi and Yuhong Chen
    Citation: Cardiovascular Diabetology 2014 13:139
    Content type: Original investigation Published on:

  6. There has been uncertainty regarding the benefit of glycemic control with antidiabetic agents in prevention of diabetic macrovascular disease. Further development of novel antidiabetic agents is essential for ...

    Authors: Bowen Lin, Nobutaka Koibuchi, Yu Hasegawa, Daisuke Sueta, Kensuke Toyama, Ken Uekawa, MingJie Ma, Takashi Nakagawa, Hiroaki Kusaka and Shokei Kim-Mitsuyama
    Citation: Cardiovascular Diabetology 2014 13:148
    Content type: Original investigation Published on:

  7. Central hemodynamics help to maintain appropriate cerebral and other end-organ perfusion, and may be altered with ageing and type 2 diabetes mellitus (T2DM). We aimed to determine the associations between cent...

    Authors: Rachel ED Climie, Velandai Srikanth, Richard Beare, Laura J Keith, James Fell, Justin E Davies and James E Sharman
    Citation: Cardiovascular Diabetology 2014 13:143
    Content type: Original investigation Published on:

  9. The present study investigated the impact of overall obesity defined by BMI and abdominal obesity defined by WC on vascular atherosclerotic changes in obese and normal weight diabetic subjects.

    Authors: Alla Lukich, Dov Gavish and Marina Shargorodsky
    Citation: Cardiovascular Diabetology 2014 13:141
    Content type: Original investigation Published on:

  10. To directly compare traditional lipid ratios (total cholesterol [TC]/high density lipoprotein cholesterol [HDL-C], non-HDL-C/HDL-C, low density lipoprotein cholesterol [LDL-C]/HDL-C, and triglycerides [TG]/HDL...

    Authors: Tingting Du, Gang Yuan, Muxun Zhang, Xinrong Zhou, Xingxing Sun and Xuefeng Yu
    Citation: Cardiovascular Diabetology 2014 13:146
    Content type: Original investigation Published on:

  11. To estimate cardiovascular disease (CVD) mortality in relation to obesity and gender.

    Authors: Xin Song, Adam G Tabák, Björn Zethelius, John S Yudkin, Stefan Söderberg, Tiina Laatikainen, Coen DA Stehouwer, Rachel Dankner, Pekka Jousilahti, Altan Onat, Peter M Nilsson, Ilhan Satman, Olga Vaccaro, Jaakko Tuomilehto and Qing Qiao
    Citation: Cardiovascular Diabetology 2014 13:144
    Content type: Original investigation Published on:

  12. Endothelial progenitor cells (EPC) are bone marrow-derived cells which can undergo differentiation into endothelial cells and participate in endothelial repair and angiogenesis. Insulin facilitates this in vit...

    Authors: Dimitrios Oikonomou, Stefan Kopf, Rüdiger von Bauer, Zdenka Djuric, Rita Cebola, Anja Sander, Stefan Englert, Spiros Vittas, Asa Hidmark, Michael Morcos, Grigorios Korosoglou, Peter P Nawroth and Per M Humpert
    Citation: Cardiovascular Diabetology 2014 13:137
    Content type: Original investigation Published on:

  13. Cardiovascular disease (CVD) is the leading cause of death in type 2 diabetes mellitus (T2DM). American Diabetes Association standards of care set a series of targets recommended for the CVD prevention: blood ...

    Authors: Maria-Agata Miselli, Edoardo Dalla Nora, Angelina Passaro, Franco Tomasi and Giovanni Zuliani
    Citation: Cardiovascular Diabetology 2014 13:135
    Content type: Original investigation Published on:

  14. Previous research has demonstrated that hyperglycemia may protect the heart against ischemic injury. The aim of the present study was to investigate the association between hyperglycemia and myocardial infarct...

    Authors: Christiane Malfitano, Catarina Andrade Barboza, Cristiano Mostarda, Renata Kelly da Palma, Camila Paixão dos Santos, Bruno Rodrigues, Sarah Cristina Ferreira Freitas, Adriane Belló-Klein, Susana Llesuy, Maria-Cláudia Irigoyen and Kátia De Angelis
    Citation: Cardiovascular Diabetology 2014 13:131
    Content type: Original investigation Published on:

  15. History of gestational diabetes mellitus (GDM) identifies a very young population of females predisposed for type 2 diabetes and cardiovascular disease. Endothelial dysfunction might represent a shared precurs...

    Authors: Christian S Göbl, Latife Bozkurt, Rajashri Yarragudi, Thomas Prikoszovich, Andrea Tura, Giovanni Pacini, Renate Koppensteiner and Alexandra Kautzky-Willer
    Citation: Cardiovascular Diabetology 2014 13:138
    Content type: Original investigation Published on:

  16. The visceral adiposity index (VAI) is a newly-derived measure of visceral adiposity with well-validated predictive power for cardiovascular (CV) outcomes in the general population. However, this predictability...

    Authors: Hung-Yuan Chen, Yen-Ling Chiu, Yi-Fang Chuang, Shih-Ping Hsu, Mei-Fen Pai, Ju-Yeh Yang and Yu-Sen Peng
    Citation: Cardiovascular Diabetology 2014 13:136
    Content type: Original investigation Published on:

  17. Excessive levels of methylglyoxal (MG) encountered in diabetes foster enhanced leukocyte-endothelial cell interactions, mechanisms of which are incompletely understood. MG genomically upregulates endothelial s...

    Authors: Syed M Qadri, Yang Su, Francisco S Cayabyab and Lixin Liu
    Citation: Cardiovascular Diabetology 2014 13:134
    Content type: Original investigation Published on:

  18. Metformin, a standard therapy in type 2 diabetes, reduces vitamin B12 levels. Studies linking low vitamin B12 levels and cardiovascular disease are equivocal and suggest improving B12 levels may help in primar...

    Authors: Antonysunil Adaikalakoteswari, Ramamurthy Jayashri, Nithya Sukumar, Hema Venkataraman, Rajendra Pradeepa, Kuppan Gokulakrishnan, Ranjit Mohan Anjana, Philip G McTernan, Gyanendra Tripathi, Vinod Patel, Sudhesh Kumar, Viswanathan Mohan and Ponnusamy Saravanan
    Citation: Cardiovascular Diabetology 2014 13:129
    Content type: Original investigation Published on:

  20. The pathogenesis of cardiovascular (CV) mortality, whose rate is increased in type 2 diabetes, is poorly understood.

    Authors: Claudia Menzaghi, Min Xu, Lucia Salvemini, Concetta De Bonis, Giuseppe Palladino, Tao Huang, Massimiliano Copetti, Yan Zheng, Yanping Li, Grazia Fini, Frank B Hu, Simonetta Bacci, Lu Qi and Vincenzo Trischitta
    Citation: Cardiovascular Diabetology 2014 13:130
    Content type: Original investigation Published on:

  21. Exendin-4, an exogenous glucagon-like peptide-1 receptor (GLP-1R) agonist, protects the heart from ischemia/reperfusion injury. However, the mechanisms for this protection are poorly understood. Caveolae, sarc...

    Authors: Yasuo M Tsutsumi, Rie Tsutsumi, Eisuke Hamaguchi, Yoko Sakai, Asuka Kasai, Yoshihiro Ishikawa, Utako Yokoyama and Katsuya Tanaka
    Citation: Cardiovascular Diabetology 2014 13:132
    Content type: Original investigation Published on:

  22. Brachial-ankle pulse wave velocity (baPWV) is a method to estimate arterial stiffness, which reflects the stiffness of both the aorta and peripheral artery; it would be applicable to general practice, since it...

    Authors: Naoto Katakami, Takeshi Osonoi, Mitsuyoshi Takahara, Miyoko Saitou, Taka-aki Matsuoka, Yoshimitsu Yamasaki and Iichiro Shimomura
    Citation: Cardiovascular Diabetology 2014 13:128
    Content type: Original investigation Published on:

  23. To assess whether the Multidisciplinary Risk Assessment and Management Program for Patients with Diabetes Mellitus (RAMP-DM) led to improvements in biomedical outcomes, observed cardiovascular events and predi...

    Authors: Fang Fang Jiao, Colman Siu Cheung Fung, Carlos King Ho Wong, Yuk Fai Wan, Daisy Dai, Ruby Kwok and Cindy Lo Kuen Lam
    Citation: Cardiovascular Diabetology 2014 13:127
    Content type: Original investigation Published on:

  24. Fatty acid-binding protein 4 (FABP4) is expressed in both adipocytes and macrophages. Recent studies have shown secretion of FABP4 from adipocytes and association of elevated serum FABP4 level with obesity, in...

    Authors: Takahiro Fuseya, Masato Furuhashi, Satoshi Yuda, Atsuko Muranaka, Mina Kawamukai, Tomohiro Mita, Shutaro Ishimura, Yuki Watanabe, Kyoko Hoshina, Marenao Tanaka, Kohei Ohno, Hiroshi Akasaka, Hirofumi Ohnishi, Hideaki Yoshida, Shigeyuki Saitoh, Kazuaki Shimamoto…
    Citation: Cardiovascular Diabetology 2014 13:126
    Content type: Original investigation Published on:

  25. Abnormal ventricular repolarization is a predictor of cardiovascular mortality. In this study, we tested the hypothesis that glycemic control reverses abnormal ventricular repolarization in patients with type ...

    Authors: Takayuki Miki, Toshiyuki Tobisawa, Tatsuya Sato, Masaya Tanno, Toshiyuki Yano, Hiroshi Akasaka, Atsushi Kuno, Makoto Ogasawara, Hiromichi Murase, Shigeyuki Saitoh and Tetsuji Miura
    Citation: Cardiovascular Diabetology 2014 13:125
    Content type: Original investigation Published on:

  26. Although no receptor has yet been identified, changes in circulating levels of the adipokine designated as Omentin have been demonstrated in obesity and related comorbidities such as cardiovascular disease, in...

    Authors: Marc Lapointe, Paul Poirier, Julie Martin, Marjorie Bastien, Audrey Auclair and Katherine Cianflone
    Citation: Cardiovascular Diabetology 2014 13:124
    Content type: Original investigation Published on:

  27. The interplay between the novel adipokine retinol-binding protein-4 (RBP4) and coronary artery disease (CAD) is still obscure. We investigated the relationship between RBP4 levels and the presence and severity...

    Authors: Vaia Lambadiari, Nikolaos PE Kadoglou, Vassilios Stasinos, Eirini Maratou, Aias Antoniadis, Fotios Kolokathis, John Parissis, Erifili Hatziagelaki, Efstathios K Iliodromitis and George Dimitriadis
    Citation: Cardiovascular Diabetology 2014 13:121
    Content type: Original investigation Published on:

  28. Nestin was reported to directly contribute to cell proliferation and the intermediate filament protein was detected in vascular smooth muscle cells. In experimental type I diabetes, nestin downregulation in th...

    Authors: Kim Tardif, Vanessa Hertig, Camille Dumais, Louis Villeneuve, Louis Perrault, Jean-François Tanguay and Angelino Calderone
    Citation: Cardiovascular Diabetology 2014 13:119
    Content type: Original investigation Published on:

  29. Pathophysiological processes underlying diabetic-related cardiomyopathies are complex. Mitochondria dysfunction is often described as a cause of cardiac impairment but its extent may depend on the type of expe...

    Authors: Camille Marciniak, Xavier Marechal, David Montaigne, Remi Neviere and Steve Lancel
    Citation: Cardiovascular Diabetology 2014 13:118
    Content type: Original investigation Published on:

  30. Patients with type 2 diabetes are at a high risk for acute cardiovascular events, which usually arise from the rupture of a vulnerable coronary lesion characterized by specific morphological plaque features. T...

    Authors: Mathias Burgmaier, Martin Hellmich, Nikolaus Marx and Sebastian Reith
    Citation: Cardiovascular Diabetology 2014 13:117
    Content type: Original investigation Published on:

  31. Evidence from the literature suggests diminished acetylsalicylic acid (ASA) treatment efficacy in type 2 diabetes (DM2). High on-aspirin platelet reactivity (HAPR) in DM2 has been linked to poor glycemic and l...

    Authors: Agnieszka Kaplon-Cieslicka, Marek Postula, Marek Rosiak, Michal Peller, Agnieszka Kondracka, Agnieszka Serafin, Ewa Trzepla, Grzegorz Opolski and Krzysztof J Filipiak
    Citation: Cardiovascular Diabetology 2014 13:112
    Content type: Original investigation Published on:

  32. We have previously shown that EphrinA1/EphA expression profile changes in response to myocardial infarction (MI), exogenous EphrinA1-Fc administration following MI positively influences wound healing, and that...

    Authors: Augustin DuSablon, Susan Kent, Anita Coburn and Jitka Virag
    Citation: Cardiovascular Diabetology 2014 13:114
    Content type: Original investigation Published on:

  33. The aim of this study was to probe cardiac complications, including heart-rate control, in a mouse model of type-2 diabetes. Heart-rate development in diabetic patients is not straight forward: In general, pat...

    Authors: Ewa Soltysinska, Tobias Speerschneider, Sine V Winther and Morten B Thomsen
    Citation: Cardiovascular Diabetology 2014 13:122
    Content type: Original investigation Published on:

  34. Atrial fibrillation (AF), an inflammatory process involving arrhythmia, is associated with severe morbidity and mortality and commonly seen in patients with diabetes mellitus (DM). The effect of metformin, the...

    Authors: Shang-Hung Chang, Lung-Sheng Wu, Meng-Jiun Chiou, Jia-Rou Liu, Kuang-Hui Yu, Chang-Fu Kuo, Ming-Shien Wen, Wei-Jan Chen, Yung-Hsin Yeh and Lai-Chu See
    Citation: Cardiovascular Diabetology 2014 13:123
    Content type: Original investigation Published on:

  35. Growing evidence demonstrates subtle left ventricular myocardial dysfunction in patients with metabolic syndrome (MetS), with central obesity, glucose intolerance and inflammation emerging as important contrib...

    Authors: Juan Serrano-Ferrer, Guillaume Walther, Edward Crendal, Agnès Vinet, Frédéric Dutheil, Geraldine Naughton, Bruno Lesourd, Robert Chapier, Daniel Courteix and Philippe Obert
    Citation: Cardiovascular Diabetology 2014 13:116
    Content type: Original investigation Published on:

  37. We previously demonstrated that older beagles have impaired whole body and myocardial insulin responsiveness (MIR), and that glucagon-like peptide-1 (GLP-1 [7–36] amide) improves MIR in young beagles with dila...

    Authors: Melissa Chen, Franca S Angeli, You-tang Shen and Richard P Shannon
    Citation: Cardiovascular Diabetology 2014 13:115
    Content type: Original investigation Published on:

  38. It has been reported that increased expression of UCP-2 in the vasculature may prevent the development of atherosclerosis in patients with increased production of reactive oxygen species, as in the diabetes, o...

    Authors: Almudena Gómez-Hernández, Liliana Perdomo, Natalia de las Heras, Nuria Beneit, Óscar Escribano, Yolanda F Otero, Carlos Guillén, Sabela Díaz-Castroverde, Beatriz Gozalbo-López, Victoria Cachofeiro, Vicente Lahera and Manuel Benito
    Citation: Cardiovascular Diabetology 2014 13:108
    Content type: Original investigation Published on:

  39. Sepsis is a common disease that continues to increase in incidence in the world. Diseases, such as diabetes mellitus, may make the situation worse. Diabetic patients are at increased risk for common infections...

    Authors: Jian Cai, Shuai Lu, Zheng Yao, Ya-Ping Deng, Ling-Di Zhang, Jia-Wen Yu, Guo-Fei Ren, Fu-Ming Shen and Guo-Jun Jiang
    Citation: Cardiovascular Diabetology 2014 13:106
    Content type: Original investigation Published on:

  40. Alpha glucosidase inhibitor (GI) attenuates postprandial hyperglycemia (PPH) and reduces the risk of cardiovascular events in patients with impaired glucose tolerance or type 2 diabetes. Dipeptidyl peptidase 4...

    Authors: Kazufumi Nakamura, Hiroki Oe, Hajime Kihara, Kenei Shimada, Shota Fukuda, Kyoko Watanabe, Tsutomu Takagi, Kei Yunoki, Toru Miyoshi, Kumiko Hirata, Junichi Yoshikawa and Hiroshi Ito
    Citation: Cardiovascular Diabetology 2014 13:110
    Content type: Original investigation Published on:

  41. Endothelial nitric oxide synthase (eNOS)-uncoupling links obesity-associated insulin resistance and type-II diabetes to the increased incidence of cardiovascular disease. Studies have indicated that increased ...

    Authors: Yi Yu, Angana G Rajapakse, Jean-Pierre Montani, Zhihong Yang and Xiu-Fen Ming
    Citation: Cardiovascular Diabetology 2014 13:113
    Content type: Original investigation Published on:

  42. Although obesity is still considered a risk factor in the development of cardiovascular disorders, recent studies suggested that it may also be associated with reduced morbidity and mortality, the so-called “o...

    Authors: Ruduwaan Salie, Barbara Huisamen and Amanda Lochner
    Citation: Cardiovascular Diabetology 2014 13:109
    Content type: Original investigation Published on:

  43. Circulating endothelial progenitor cells (EPCs) reflect endothelial repair capacity and may be a significant marker for the clinical outcomes of cardiovascular disease. While some high-dose statin treatments m...

    Authors: Liang-Yu Lin, Chin-Chou Huang, Jia-Shiong Chen, Tao-Cheng Wu, Hsin-Bang Leu, Po-Hsun Huang, Ting-Ting Chang, Shing-Jong Lin and Jaw-Wen Chen
    Citation: Cardiovascular Diabetology 2014 13:111
    Content type: Original investigation Published on:

  44. Hyperglycemia has been recognized as a primary factor in endothelial barrier dysfunction and in the development of micro- and macrovascular diseases associated with diabetes, but the underlying biochemical mec...

    Authors: Mehran Haidari, Wei Zhang, James T Willerson and Richard AF Dixon
    Citation: Cardiovascular Diabetology 2014 13:112
    Content type: Original investigation Published on:

  45. Hyperglycemia has been recognized as a primary factor in endothelial barrier dysfunction and in the development of micro- and macrovascular diseases associated with diabetes, but the underlying biochemical mec...

    Authors: Mehran Haidari, Wei Zhang, James T Willerson and Richard AF Dixon
    Citation: Cardiovascular Diabetology 2014 13:105
    Content type: Original investigation Published on:

  47. Women with gestational diabetes history are at increased risk for type 2 diabetes. They face specific challenges for behavioural changes, including childcare responsibilities. The aim of this study is to test ...

    Authors: Anne-Sophie Brazeau, Aaron Leong, Sara J Meltzer, Rani Cruz, Deborah DaCosta, Mary Hendrickson-Nelson, Lawrence Joseph and Kaberi Dasgupta
    Citation: Cardiovascular Diabetology 2014 13:104
    Content type: Original investigation Published on:

  49. Evidence concerning the importance of glucose lowering in the prevention of cardiovascular (CV) outcomes remains controversial. Given the multi-faceted pathogenesis of atherosclerosis in diabetes, it is likely...

    Authors: Bernard Zinman, Silvio E Inzucchi, John M Lachin, Christoph Wanner, Roberto Ferrari, David Fitchett, Erich Bluhmki, Stefan Hantel, Joan Kempthorne-Rawson, Jennifer Newman, Odd Erik Johansen, Hans-Juergen Woerle and Uli C Broedl
    Citation: Cardiovascular Diabetology 2014 13:102
    Content type: Study protocol Published on:

  50. Diabetic patients have a significantly worse prognosis after an acute myocardial infarction (AMI) than their counterparts. Previous studies have shown that the number of circulating endothelial progenitor cell...

    Authors: Natália António, Rosa Fernandes, Ana Soares, Francisco Soares, Ana Lopes, Tiago Carvalheiro, Artur Paiva, Guilherme Mariano Pêgo, Luís A Providência, Lino Gonçalves and Carlos Fontes Ribeiro
    Citation: Cardiovascular Diabetology 2014 13:101
    Content type: Original investigation Published on:
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