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  1. Data regarding the long-term clinical outcomes in patients with insulin-treated type 2 diabetes mellitus (ITDM) revascularized by either coronary artery bypass surgery (CABG) or percutaneous coronary intervent...

    Authors: Pravesh Kumar Bundhun, Zi Jia Wu and Meng-Hua Chen
    Citation: Cardiovascular Diabetology 2016 15:2
    Content type: Original investigation Published on:

  2. Previous studies have shown that angiopoietin-like protein 8 (ANGPTL8), also called as betatrophin, acts together with ANGPTL3 to regulate lipid metabolism, glucose metabolism, and energy homeostasis. Moreover...

    Authors: Hye Soo Chung, Min Jung Lee, Soon Young Hwang, Hyun Jung Lee, Hye Jin Yoo, Ji-A Seo, Sin Gon Kim, Nan Hee Kim, Sei Hyun Baik, Dong Seop Choi, Seon Mi Kim and Kyung Mook Choi
    Citation: Cardiovascular Diabetology 2016 15:1
    Content type: Original investigation Published on:

  3. To investigate the long-term efficacy and safety of empagliflozin monotherapy compared with placebo and sitagliptin in drug-naïve patients with type 2 diabetes mellitus.

    Authors: Michael Roden, Ludwig Merker, Anita Vedel Christiansen, Flavien Roux, Afshin Salsali, Gabriel Kim, Peter Stella, Hans J. Woerle and Uli C. Broedl
    Citation: Cardiovascular Diabetology 2015 14:154
    Content type: Original Investigation Published on:

  4. States of hyperinsulinemia, particularly insulin resistance and type 2 diabetes mellitus, are becoming remarkably common, with roughly half a billion people likely to suffer from the disorder within the next 1...

    Authors: Aimee E. Hodson, Trevor S. Tippetts and Benjamin T. Bikman
    Citation: Cardiovascular Diabetology 2015 14:153
    Content type: Original investigation Published on:

  5. To determine temporal changes in the prevalence and associates of lower extremity amputation (LEA) complicating type 2 diabetes.

    Authors: Mendel Baba, Wendy A. Davis, Paul E. Norman and Timothy M. E. Davis
    Citation: Cardiovascular Diabetology 2015 14:152
    Content type: Original investigation Published on:

  6. Remote ischemic perconditioning (RIPerC) has a promising therapeutic insight to improve the prognosis of acute myocardial infarction. Chronic comorbidities such as diabetes are known to interfere with conditio...

    Authors: Tamás Baranyai, Csilla Terézia Nagy, Gábor Koncsos, Zsófia Onódi, Melinda Károlyi-Szabó, András Makkos, Zoltán V. Varga, Péter Ferdinandy and Zoltán Giricz
    Citation: Cardiovascular Diabetology 2015 14:151
    Content type: Original investigation Published on:

  7. It remains to be established if, and to what extent, the coronary microcirculation becomes compromised during the development of obesity and insulin resistance. Recent studies suggest that changes in endotheli...

    Authors: Judith van Haare, M. Eline Kooi, Hans Vink, Mark J. Post, Jurgen W. G. E. van Teeffelen, Jos Slenter, Chantal Munts, Hanneke Cobelens, Gustav J. Strijkers, Dennis Koehn and Marc van Bilsen
    Citation: Cardiovascular Diabetology 2015 14:150
    Content type: Original investigation Published on:

    The Correction to this article has been published in Cardiovascular Diabetology 2021 20:51

  8. The effects of streptozotocin (STZ)-induced diabetes on heart metabolism and function after myocardial infarction (MI) remodelling were investigated in rats.

    Authors: Christiane Malfitano, Alcione Lescano de Souza Junior, Mariana Carbonaro, Andressa Bolsoni-Lopes, Diego Figueroa, Leandro Ezequiel de Souza, Kleiton Augusto Santos Silva, Fernanda Consolim-Colombo, Rui Curi and Maria Claudia Irigoyen
    Citation: Cardiovascular Diabetology 2015 14:149
    Content type: Original investigation Published on:

  9. The heart requires constant sources of energy mostly from free fatty acids (FFA) and glucose. The alteration in myocardial substrate metabolism occurs in the heart of diabetic patients, but its specific associ...

    Authors: Gyuri Kim, Kwanhyeong Jo, Kwang Joon Kim, Yong-ho Lee, Eugene Han, Hye-jin Yoon, Hye Jin Wang, Eun Seok Kang and Mijin Yun
    Citation: Cardiovascular Diabetology 2015 14:148
    Content type: Original investigation Published on:

  10. Few studies have investigated the association between coronary artery calcium (CAC) progression and arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV). We examined the influence of the s...

    Authors: Jong-Young Lee, Seungho Ryu, Sung Ho Lee, Byung Jin Kim, Bum-Soo Kim, Jin-Ho Kang, Eun Sun Cheong, Jang-Young Kim, Jeong Bae Park and Ki-Chul Sung
    Citation: Cardiovascular Diabetology 2015 14:147
    Content type: Original investigation Published on:

  11. Type 2 diabetes mellitus is an important risk factor in the development of coronary artery disease (CAD) and is often associated with severe disease. However, this risk is not uniform, some patients remain fre...

    Authors: Mukund P. Srinivasan, Padmanabh K. Kamath, Narayan M. Bhat, Narasimha D. Pai, Poornima A. Manjrekar and Chakrapani Mahabala
    Citation: Cardiovascular Diabetology 2015 14:146
    Content type: Original investigation Published on:

  12. Diabetes mellitus (DM) leads to the development of diabetic cardiomyopathy, which is associated with altered nitric oxide (NO)—soluble guanylate cyclase (sGC)—cyclic guanosine monophosphate (cGMP) signalling. ...

    Authors: Csaba Mátyás, Balázs Tamás Németh, Attila Oláh, László Hidi, Ede Birtalan, Dalma Kellermayer, Mihály Ruppert, Sevil Korkmaz-Icöz, Gábor Kökény, Eszter Mária Horváth, Gábor Szabó, Béla Merkely and Tamás Radovits
    Citation: Cardiovascular Diabetology 2015 14:145
    Content type: Original investigation Published on:

  13. We aimed to determine the association between nonalcoholic fatty liver disease (NAFLD) and diabetes risk among body size phenotypes which was based on cross-classification of body mass index (BMI) categories (...

    Authors: Tingting Du, Xuefeng Yu, Gang Yuan, Jianhua Zhang and Xingxing Sun
    Citation: Cardiovascular Diabetology 2015 14:144
    Content type: Original investigation Published on:

  14. Diabetic patients are more sensitive to myocardial ischemic injury than non-diabetic patients. Silent information regulator 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent histone deacetylase making...

    Authors: Mingge Ding, Jingyi Lei, Hongcheng Han, Weibo Li, Yinxian Qu, Enqing Fu, Feng Fu and Xiaoming Wang
    Citation: Cardiovascular Diabetology 2015 14:143
    Content type: Original investigation Published on:

  15. Although antidiabetic agents have been developed to target one or more of the core defects of type 2 diabetes mellitus (T2DM), many patients do not achieve glycemic goals. Inhibition of the sodium-glucose cotr...

    Authors: Paola Fioretto, Andrea Giaccari and Giorgio Sesti
    Citation: Cardiovascular Diabetology 2015 14:142
    Content type: Review Published on:

  16. After acute myocardial infarction (AMI), the replicated phenomenon of obesity paradox, i.e., obesity appearing to be associated with increased survival, has not been evaluated in stabilized (i.e., without clin...

    Authors: Ki-Bum Won, Seung-Ho Hur, Yun-Kyeong Cho, Hyuck-Jun Yoon, Chang-Wook Nam, Kwon-Bae Kim, Jang-Ho Bae, Dong-Ju Choi, Young-Keun Ahn, Jong-Seon Park, Hyo-Soo Kim, Rak-Kyeong Choi, Donghoon Choi, Joon-Hong Kim, Kyoo-Rok Han, Hun-Sik Park…
    Citation: Cardiovascular Diabetology 2015 14:141
    Content type: Original investigation Published on:

    The Correction to this article has been published in Cardiovascular Diabetology 2023 22:159

  17. Whereas a few studies have reported associations of serum omentin levels with subclinical atherosclerosis in patients with diabetes, little information is available with respect to the associations of serum om...

    Authors: Chan-Hee Jung, Sang-Hee Jung, Bo-Yeon Kim, Chul-Hee Kim, Sung-Koo Kang and Ji-Oh Mok
    Citation: Cardiovascular Diabetology 2015 14:140
    Content type: Original investigation Published on:

  18. The object of this study was to investigate the potential role of FGF23 on plaque stability in type 2 diabetic patients with internal carotid artery stenosis.

    Authors: Federico Biscetti, Giuseppe Straface, Carlo Filippo Porreca, Giovanni Bertoletti, Claudio Vincenzoni, Francesco Snider, Egidio Stigliano, Vincenzo Arena, Flavia Angelini, Giovanni Pecorini, Antonio Bianchi, Raffaele Landolfi and Andrea Flex
    Citation: Cardiovascular Diabetology 2015 14:139
    Content type: Original investigation Published on:

  20. Many factors influence whether the first-line oral anti-diabetic drug, metformin, should be initiated to a patient with type 2 diabetes mellitus (T2DM) early in the course of management in addition to lifestyl...

    Authors: Colman Siu Cheung Fung, Eric Yuk Fai Wan, Carlos King Ho Wong, Fangfang Jiao and Anca Ka Chun Chan
    Citation: Cardiovascular Diabetology 2015 14:137
    Content type: Original investigation Published on:

  21. Abdominal visceral obesity has been reported to be associated with cardiovascular risks than body mass index, waist circumference, and abdominal subcutaneous fat. On the other hand, there is evidence that subc...

    Authors: Ryotaro Bouchi, Takato Takeuchi, Momoko Akihisa, Norihiko Ohara, Yujiro Nakano, Rie Nishitani, Masanori Murakami, Tatsuya Fukuda, Masamichi Fujita, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto and Yoshihiro Ogawa
    Citation: Cardiovascular Diabetology 2015 14:136
    Content type: Original investigation Published on:

  22. Type 2 diabetes mellitus (DM) patients have worse adverse cardiovascular outcomes after Percutaneous Coronary Intervention (PCI). However, the adverse cardiovascular outcomes between insulin-treated and non-in...

    Authors: Pravesh Kumar Bundhun, Nuo Li and Meng-Hua Chen
    Citation: Cardiovascular Diabetology 2015 14:135
    Content type: Original investigation Published on:

  23. Diabetic cardiomyopathy (DCM), a fatal cardiovascular complication of diabetes mellitus, often leads to progressive heart failure, however its pathogenesis remains unclear. Corin, a cardiac serine protease, is...

    Authors: Aiming Pang, Yahui Hu, Pengfei Zhou, Guangfeng Long, Xin Tian, Li Men, Yanna Shen, Yunde Liu and Yujie Cui
    Citation: Cardiovascular Diabetology 2015 14:134
    Content type: Original investigation Published on:

  24. In order to influence every day clinical practice professional organisations issue management guidelines. Cross-sectional surveys are used to evaluate the implementation of such guidelines. The present survey ...

    Authors: Viveca Gyberg, Dirk De Bacquer, Guy De Backer, Catriona Jennings, Kornelia Kotseva, Linda Mellbin, Oliver Schnell, Jaakko Tuomilehto, David Wood, Lars Rydén, Philippe Amouyel, Jan Bruthans, Almudena Castro Conde, Renata Cifkova, Jaap W. Deckers, Johan De Sutter…
    Citation: Cardiovascular Diabetology 2015 14:133
    Content type: Original investigation Published on:

  25. The purpose of this study was to analyze the evolution of vascular, cardiac and renal target organ damage (TOD) in patients with increased insulin resistance over a 3.5 year follow-up and to investigate gender...

    Authors: Manuel Ángel Gómez-Marcos, José Ignacio Recio-Rodríguez, Leticia Gómez-Sánchez, Cristina Agudo-Conde, Emiliano Rodríguez-Sanchez, JoseAngel Maderuelo-Fernandez, Marta Gomez-Sanchez and Luís García-Ortiz
    Citation: Cardiovascular Diabetology 2015 14:132
    Content type: Original investigation Published on:

  26. Diabetes mellitus (DM) and aortic stenosis (AS) are frequent findings in the elderly population. Data regarding the influence of DM on the outcomes of patients undergoing transcatheter aortic valve replacemen...

    Authors: Anat Berkovitch, Amit Segev, Israel Barbash, Yoni Grossman, Elad Maor, Aharon Erez, Ehud Regev, Noam Fink, Israel Mazin, Ashraf Hamdan, Ilan Goldenberg, Ilan Hay, Dan Spiegelstien, Victor Guetta and Paul Fefer
    Citation: Cardiovascular Diabetology 2015 14:131
    Content type: Original investigation Published on:

  27. Increased cardiac fat has been identified as a risk factor for coronary artery disease. Metabolic syndrome is associated with increased cardiac fat deposition. Steroids are known to imitate some effects of met...

    Authors: Daniel Kitterer, Joerg Latus, Joerg Henes, Stefan Birkmeier, Maik Backes, Niko Braun, Udo Sechtem, M. Dominik Alscher, Heiko Mahrholdt and Simon Greulich
    Citation: Cardiovascular Diabetology 2015 14:130
    Content type: Original investigation Published on:

  29. Authors: Stijn A Peeters, Lian Engelen, Jacqueline Buijs, Nish Chaturvedi, John H Fuller, Casper G Schalkwijk and Coen D Stehouwer
    Citation: Cardiovascular Diabetology 2015 14:128
    Content type: Erratum Published on:

    The original article was published in Cardiovascular Diabetology 2015 14:31

  30. Cardiomyopathy is a devastating complication of obesity and type 2 diabetes mellitus (T2DM). It arises even in patients with normoglycemia (glycosylated hemoglobin, A1C ≤7 %). As obesity and T2DM are approachi...

    Authors: Nathan W. Roberts, Magdalis González-Vega, Tirsit K. Berhanu, Aaron Mull, Jesús García and Ahlke Heydemann
    Citation: Cardiovascular Diabetology 2015 14:127
    Content type: Original investigation Published on:

  31. Advanced glycation end products (AGEs) play a role in the development of late complications and atherosclerosis in diabetes by engaging the receptor for advanced glycation end products, RAGE. Receptor binding ...

    Authors: Martin Heier, Hanna Dis Margeirsdottir, Mario Gaarder, Knut Haakon Stensæth, Cathrine Brunborg, Peter Abusdal Torjesen, Ingebjørg Seljeflot, Kristian Folkvord Hanssen and Knut Dahl-Jørgensen
    Citation: Cardiovascular Diabetology 2015 14:126
    Content type: Original investigation Published on:

  32. IL-1β was considered as an important inflammatory cytokine in diabetic cardiovascular complications. DCM is one of the major manifestations of diabetic cardiovascular complications whose specific mechanisms ar...

    Authors: Zhongwei Liu, Na Zhao, Huolan Zhu, Shunming Zhu, Shuo Pan, Jing Xu, Xuejun Zhang, Yong Zhang and Junkui Wang
    Citation: Cardiovascular Diabetology 2015 14:125
    Content type: Original investigation Published on:

  33. Whether lowering glycosylated haemoglobin (HbA1c) level below 7.0 % improves macro-vascular outcomes in diabetes remains unclear. Here, we aimed to assess the effect of relatively tight glucose control resulti...

    Authors: Pin Wang, Rong Huang, Sen Lu, Wenqing Xia, Haixia Sun, Jie Sun, Rongrong Cai and Shaohua Wang
    Citation: Cardiovascular Diabetology 2015 14:124
    Content type: Original investigation Published on:

  34. Type 2 diabetes mellitus (T2DM) complicated by retinopathy is associated with altered left ventricular (LV) structure and resting myocardial dysfunction unlike T2DM without retinopathy. The myocardial response...

    Authors: Zhe Zhen, Yan Chen, Kendrick Shih, Ju-Hua Liu, Michele Yuen, David Sai-Hung Wong, Karen Siu-Ling Lam, Hung-Fat Tse and Kai-Hang Yiu
    Citation: Cardiovascular Diabetology 2015 14:123
    Content type: Original investigation Published on:

  35. Whole body cardiovascular MR (WB CVMR) combines whole body angiography and cardiac MR assessment. It is accepted that there is a high disease burden in patients with diabetes, however the quantification of the...

    Authors: Suzanne L. Duce, Jonathan R. Weir-McCall, Stephen J. Gandy, Shona Z. Matthew, Deirdre B. Cassidy, Lynne McCormick, Petra Rauchhaus, Helen Looker, Helen M. Colhoun and J. Graeme Houston
    Citation: Cardiovascular Diabetology 2015 14:122
    Content type: Original investigation Published on:

  36. The glycoprotein YKL-40 is a new marker of early inflammation and endothelial dysfunction. Adiponectin is a collagen-like protein with anti-atherogenic and anti-inflammatory effects. Increased concentrations o...

    Authors: Eva Aguilera, Enric Serra-Planas, M. Luisa Granada, Silvia Pellitero, Jordi L. Reverter, Núria Alonso, Berta Soldevila, Dídac Mauricio and Manel Puig-Domingo
    Citation: Cardiovascular Diabetology 2015 14:121
    Content type: Original investigation Published on:

  37. Diabetes and impaired glucose tolerance (IGT) are major risk factors for atherosclerosis including coronary artery disease (CAD). The present study’s aim was to investigate the importance of glucose tolerance ...

    Authors: Jeanette Kuhl, Gun Jörneskog, Malin Wemminger, Mattias Bengtsson, Pia Lundman and Majid Kalani
    Citation: Cardiovascular Diabetology 2015 14:120
    Content type: Original investigation Published on:

  38. Left ventricular (LV) diastolic dysfunction (LVDD) is a well-established and early echocardiographic characteristic of diabetic cardiomyopathy. However, there are limited data on the association between impair...

    Authors: Assi Milwidsky, Elad Maor, Shaye Kivity, Anat Berkovitch, Sagit Ben Zekry, Alexander Tenenbaum, Enrique Z. Fisman, Aharon Erez, Shlomo Segev, Yechezkel Sidi, Ilan Goldenberg and Rafael Kuperstein
    Citation: Cardiovascular Diabetology 2015 14:119
    Content type: Original investigation Published on:

  39. We recently reported strong associations between eight skin collagen AGEs and two solubility markers from skin biopsies obtained at DCCT study closeout and the long-term progression of microvascular disease in...

    Authors: Vincent M Monnier, Wanjie Sun, Xiaoyu Gao, David R Sell, Patricia A Cleary, John M Lachin and Saul Genuth
    Citation: Cardiovascular Diabetology 2015 14:118
    Content type: Original investigation Published on:

    The Erratum to this article has been published in Cardiovascular Diabetology 2015 14:138

  40. It has been shown that visceral fat accumulation is associated with autonomic dysfunction, though the precise mechanism remains unclear. A recent basic study found that leptin can directly modulate autonomic f...

    Authors: Masafumi Kurajoh, Hidenori Koyama, Manabu Kadoya, Mariko Naka, Akio Miyoshi, Akinori Kanzaki, Miki Kakutani-Hatayama, Hirokazu Okazaki, Takuhito Shoji, Yuji Moriwaki, Tetsuya Yamamoto, Masanori Emoto, Masaaki Inaba and Mitsuyoshi Namba
    Citation: Cardiovascular Diabetology 2015 14:117
    Content type: Original investigation Published on:

  41. The risk of cardiovascular morbidity and mortality is significantly increased in patients with diabetes; thus, it is important to determine whether glucose-lowering therapy affects this risk over time. Changes...

    Authors: Rafael Simó, Bruno Guerci, Guntram Schernthaner, Baptist Gallwitz, Juan Rosas-Guzmàn, Francesco Dotta, Andreas Festa, Ming Zhou and Jacek Kiljański
    Citation: Cardiovascular Diabetology 2015 14:116
    Content type: Original investigation Published on:

  43. Hyperglycemia is the hallmark of diabetes and its cardiovascular complications. Insulin plays an important role in the regulation of vascular homeostasis and maintenance of endothelial function. Insulin signal...

    Authors: Valeria De Nigris, Gemma Pujadas, Lucia La Sala, Roberto Testa, Stefano Genovese and Antonio Ceriello
    Citation: Cardiovascular Diabetology 2015 14:114
    Content type: Original investigation Published on:

  44. The hyperinsulinemia of obesity is a function of both increased pancreatic insulin secretion and decreased insulin clearance, and contributes to cardiovascular risk. Whilst weight loss is known to enhance insu...

    Authors: Nora E. Straznicky, Mariee T. Grima, Carolina I. Sari, Elisabeth A. Lambert, Sarah E. Phillips, Nina Eikelis, Daisuke Kobayashi, Dagmara Hering, Justin A. Mariani, John B. Dixon, Paul J. Nestel, Sofie Karapanagiotidis, Markus P. Schlaich and Gavin W. Lambert
    Citation: Cardiovascular Diabetology 2015 14:113
    Content type: Original investigation Published on:

  45. Betatrophin has been suggested as an inducer of β-cell proliferation in mice in addition to its function in regulating triglyceride. Recent data showed that betatrophin was increased in Type 2 Diabetes (T2D), ...

    Authors: Mohamed Abu-Farha, Jehad Abubaker, Fiona Noronha, Irina Al-Khairi, Preethi Cherian, Monira Alarouj, Abdullah Bennakhi and Naser Elkum
    Citation: Cardiovascular Diabetology 2015 14:112
    Content type: Original investigation Published on:

  46. Blood glucose variability is receiving considerable attention as a new risk factor for coronary artery disease. This study aimed to investigate the association between blood glucose variability and coronary pl...

    Authors: Kozo Okada, Kiyoshi Hibi, Masaomi Gohbara, Shunsuke Kataoka, Keiko Takano, Eiichi Akiyama, Yasushi Matsuzawa, Kenichiro Saka, Nobuhiko Maejima, Mitsuaki Endo, Noriaki Iwahashi, Kengo Tsukahara, Masami Kosuge, Toshiaki Ebina, Peter J. Fitzgerald, Yasuhiro Honda…
    Citation: Cardiovascular Diabetology 2015 14:111
    Content type: Original investigation Published on:

  47. The Global Registry of Acute Coronary Events (GRACE) risk score is widely recommended for risk assessment in patients with acute coronary syndrome (ACS). Chronic hyperglycemia [hemoglobinA1c (HbA1c)] can indep...

    Authors: Xiao-Jun Liu, Zhao-Fei Wan, Na Zhao, Ya-Ping Zhang, Lan Mi, Xin-Hong Wang, Dong Zhou, Yan Wu and Zu-Yi Yuan
    Citation: Cardiovascular Diabetology 2015 14:110
    Content type: Original investigation Published on:

  49. With the increasing trend of metabolic syndrome (MetS) and atherothrombotic stroke (which can manifest as stroke lesion multiplicity), studies on the association between MetS and the clinical aspects of athero...

    Authors: Kazuhiko Kotani, Noriko Satoh-Asahara, Takuya Nakakuki, Hajime Yamakage, Akira Shimatsu and Tetsuya Tsukahara
    Citation: Cardiovascular Diabetology 2015 14:108
    Content type: Original investigation Published on:

  50. Coronary microvascular dysfunction (CMD) is associated with cardiovascular events in type 2 diabetes mellitus (T2DM). Optimal glycaemic control does not always preclude future events. We sought to assess the e...

    Authors: Luis Felipe Valenzuela-Garcia, Yasushi Matsuzawa, Jaskanwal D S Sara, Taek-Geun Kwon, Ryan J Lennon, Lilach O Lerman, Rafael J Ruiz-Salmeron and Amir Lerman
    Citation: Cardiovascular Diabetology 2015 14:106
    Content type: Original investigation Published on:
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Cardiovascular Diabetology

ISSN: 1475-2840