Fig. 3
From: ASGR1 deficiency diverts lipids toward adipose tissue but results in liver damage during obesity
Visceral adipose tissue presents increased lipid content in ASGR1 deficient mice. A Scheme depicting VAT processing for shotgun proteomics. Created with Biorender.com. B Volcano plot for the differently expressed proteins on VAT of WT and ASGR1−/− male mice after 20 weeks of HFD. Blue and red represent the down- and upregulated proteins respectively in ASGR1−/− mice. C Canonical pathways for the differently expressed proteins in VAT of WT and ASGR1−/− male mice after 20 weeks of HFD. D–E Abundance (Log2-transformed) of the proteins associated with the LXR/RXR pathway. D SREBP pathway activation E in WT and ASGR1−/− VAT after 20 weeks of HFD. F–H Fatty acid content from the lipid extraction in WT and ASGR1−/− mice in VAT after 20 weeks of HFD. F Total fatty acid distribution G Fatty acid content in triglycerides and H Free fatty acids (FFA) in VAT of WT and ASGR1−/− animals. Each bar and error represent the mean ± SEM. *p < 0.05, **p < 0.01 and ***p < 0.001