Table 4 Multivariate logistic regression analysis for noninvasive scores of fibrosis
GEPSAD | LIRA-NAFLD | |||
|---|---|---|---|---|
Odds-ratio [95% CI] | P-value | Odds-ratio [95% CI] | P-value | |
FIB-4 ≥ 1.30 | ||||
Total ceramides (log) | 0.48 [0.08–2.7] | 0.41 | 0.18 [8 × 10− 3–2.8] | 0.24 |
16:0 ceramide (log) | 4655 [1.5–2 × 10 7 ] | 0.04 | 10 [7 × 10− 3–8 × 104] | 0.54 |
18:0 ceramide (log) | 4.1 [0.0–9 × 105] | 0.87 | 0.72 [0.27–2.0] | 0.52 |
20:0 ceramide (log) | 1.2 [0.2–6.1] | 0.87 | 0.65 [0.14–3.1] | 0.57 |
22:0 ceramide (log) | 1.1 [0.3–5.0] | 0.15 | 1.4 [0.12–15] | 0.78 |
24:1 ceramide (log) | 0.46 [0.09–2.2] | 0.34 | 0.50 [0.05–4.5] | 0.53 |
24:0 ceramide (log) | 0.42 [0.09–1.9] | 0.26 | 0.13 [8 × 10− 3–1.7] | 0.13 |
26:0 ceramide | 2.6 [1.1–6.4] | 0.04 | 0.14 [5 × 10− 3–3.0] | 0.22 |
VLSFA ceramides (log) | 0.48 [0.10–2.3] | 0.36 | 0.18 [0.01–2.5] | 0.22 |
LCFA ceramides | 4.4 [0.63–30.6] | 0.13 | 1.0 [0.98–1.1] | 0.27 |
NFS ≥ -1.455 | ||||
Total ceramides (log) | 0.61 [0.05–6.9] | 0.40 | 0.11 [3 × 10− 4–17] | 0.79 |
16:0 ceramide (log) | 1 × 10− 4 [4 × 10− 9–6] | 0.10 | 1 × 107 [8.5–5 × 1016] | 0.06 |
18:0 ceramide (log) | 5 × 10− 6 [1 × 10− 14–2996] | 0.22 | 0.78 [0.13–6.6] | 0.79 |
20:0 ceramide (log) | 0.16 [0.01–1.7] | 0.14 | 0.65 [0.03–23] | 0.79 |
22:0 ceramide (log) | 0.43 [0.05–3.2] | 0.42 | 0.27 [5 × 10− 3–11] | 0.50 |
24:1 ceramide (log) | 1.3 [0.1–12] | 0.82 | 0.06 [5 × 10− 4–5.9] | 0.23 |
24:0 ceramide (log) | 0.7 [0.08–6.3] | 0.76 | 0.24 [2 × 10− 3–17] | 0.53 |
26:0 ceramide | 3 × 10− 5 [7 × 10− 12–227] | 0.19 | 1.26 [5 × 10− 3–292] | 0.93 |
VLSFA ceramides (log) | 0.62 [0.06–5.7] | 0.67 | 0.19 [1 × 10− 3–17] | 0.49 |
LCFA ceramides | 0.13 [0.01–1.7] | 0.11 | 1.0 [0.95–1.1] | 0.65 |
FibroTest® > 0.48 | ||||
Total ceramides (log) | 0.94 [0.06–15] | 0.97 | N.A. | N.A. |
16:0 ceramide (log) | 6 × 10− 6 [1 × 10− 12–4.4] | 0.10 | N.A. | N.A. |
18:0 ceramide (log) | 0.01 [7 × 10− 14–2 × 108] | 0.72 | N.A. | N.A. |
20:0 ceramide (log) | 0.73 [0.05–11] | 0.81 | N.A. | N.A. |
22:0 ceramide (log) | 0.58 [0.06–5.9] | 0.64 | N.A. | N.A. |
24:1 ceramide (log) | 2.4 [0.2–30] | 0.48 | N.A. | N.A. |
24:0 ceramide (log) | 0.80 [0.07–9.0] | 0.85 | N.A. | N.A. |
26:0 ceramide | 4 × 10 − 11 [1 × 10 − 21 − 0.05] | 0.04 | N.A. | N.A. |
VLSFA ceramides (log) | 0.80 [0.07–9.7] | 0.86 | N.A. | N.A. |
LCFA ceramides | 0.10 [2 × 10− 3–2.6] | 0.19 | N.A. | N.A. |
FNI ≥ 0.10 | ||||
Total ceramides (log) | 1.03 [0.16–6.8] | 0.97 | 17 [0.65–612] | 0.09 |
16:0 ceramide (log) | 1968 [0.2–4 × 107] | 0.11 | 1.2 [4 × 10− 4–4270] | 0.96 |
18:0 ceramide (log) | 2 × 10 11 [2 × 10 3 − 2 × 10 20 ] | 0.009 | 1.5 [0.41–4.7] | 0.50 |
20:0 ceramide (log) | 4.2 [0.7–25] | 0.11 | 2.0 [0.28–12] | 0.45 |
22:0 ceramide (log) | 2.2 [0.4–11] | 0.34 | 15 [0.76–475] | 0.10 |
24:1 ceramide (log) | 1.2 [0.2–6.6] | 0.87 | 9.1 [0.74–130] | 0.08 |
24:0 ceramide (log) | 0.60 [0.1–3.1] | 0.54 | 9.9 [0.49–250] | 0.14 |
26:0 ceramide | 114 [0.0–9 × 107] | 0.48 | 1.00 [0.90–1.08] | 0.99 |
VLSFA ceramides (log) | 0.77 [0.14–4.2] | 0.76 | 14 [0.60–418] | 0.11 |
LCFA ceramides | 13 [1.2–168] | 0.04 | 1.01 [0.97–1.07] | 0.58 |