Table 3 Multivariate linear regression analysis for MRI-PDFF-based liver fat content (log)
GEPSAD (n = 255) | LIRA-NAFLD (n = 80) | |||
|---|---|---|---|---|
Standardized β [95% CI] | P-value | Standardized β [95% CI] | P-value | |
Total ceramides (log) | 0.201 [0.082 0.320] | 0.001 | 0.252 [0.029–0.475] | 0.032 |
16:0 ceramide (log) | 0.001 [-0.119 0.122] | 0.98 | 0.022 [-0.067–0.109] | 0.68 |
18:0 ceramide (log) | 0.170 [0.050 0.290] | 0.006 | 0.293 [0.064–0.522] | 0.009 |
20:0 ceramide (log) | 0.138 [0.019–0.257] | 0.02 | 0.141 [-0.067–0.275] | 0.19 |
22:0 ceramide (log) | 0.203 [0.084 0.322] | 0.0009 | 0.287 [0.052–0.522] | 0.010 |
24:1 ceramide (log) | 0.102 [-0.019–0.223] | 0.10 | 0.136 [-0.090–0.362] | 0.26 |
24:0 ceramide (log) | 0.235 [0.117–0.353] | 0.0001 | 0.263 [0.031–0.495] | 0.024 |
26:0 ceramide | -0.059 [-0.178–0.061] | 0.33 | 0.021 [-0.145–0.187] | 0.47 |
VLSFA ceramides (log) | 0.237 [0.119–0.355] | 0.0001 | 0.245 [0.012–0.478] | 0.037 |
LCFA ceramides | 0.059 [-0.060–0.178] | 0.32 | -0.023 [-0.112–0.066] | 0.69 |