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Fig. 5 | Cardiovascular Diabetology

Fig. 5

From: Roles of gut microbiota in atrial fibrillation: insights from Mendelian randomization analysis and genetic data from over 430,000 cohort study participants

Fig. 5

Summary of study. We performed a two-sample Mendelian randomization (MR) analysis using summary statistics from genome-wide association studies (GWAS) of 207 gut microbial taxa (the Dutch Microbiome Project) and large meta-GWASs of AF. We identified two microbial taxa causally associated with AF: species Eubacterium ramulus and genus Holdemania. Mediation MR analyses were conducted for AF risk factors, including coronary artery disease (CAD), type 2 diabetes, body mass index (BMI), blood lipids, blood pressure, and obstructive sleep apnea. We found CAD might mediate the effect of Eubacterium ramulus, while BMI mediates the effect of Holdemania on AF. OR: odds ratio. The prefixes g. and s. indicated genus and species, respectively

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Cardiovascular Diabetology

ISSN: 1475-2840