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Fig. 7 | Cardiovascular Diabetology

Fig. 7

From: Cardioprotective function of sclerostin by reducing calcium deposition, proliferation, and apoptosis in human vascular smooth muscle cells

Fig. 7

Relative expression of genes involved in bone metabolism, inflammation and contractility evaluated by qPCR in calcified HAoSMCs overexpressing sclerostin vs. calcified mock. Relative expression of each gene of interest was assessed using the 2−ΔΔCt method. Data are represented as the mean ± standard deviation. The p-values between groups were determined by the unpaired Student´s t-test. * = p < 0.05. ALPL, alkaline phosphatase, biomineralization associated; RUNX2, runt-related transcription factor 2; IL1β, interleukin 1 beta; IL6, interleukin 6; IL8, interleukin 8; COX2, cyclooxygenase 2; ACTA2, actin aortic smooth muscle.

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Cardiovascular Diabetology

ISSN: 1475-2840