Fig. 3

ROC curve for the usefulness of serum sclerostin level as an estimator of CVD in T2D patients (n = 139). (a) Serum sclerostin levels; AUC = 0.685; p = 0.003. (b) Age, sex, hypertension, dyslipidaemia, eGFR, sedentarism, tobacco use and years of diabetes duration and serum sclerostin level; AUC = 0.795; p < 0.001. (c) Age, sex, hypertension, dyslipidaemia, eGFR, sedentarism, tobacco use and years of diabetes duration; AUC = 0.757; p < 0.001. The independent variables included in the models were the established cardiovascular risk in addition to sclerostin levels. The usefulness of serum sclerostin as an estimator of CVD risk was assessed using a ROC curve. The AUC indicates the probability to predict an event and the values greater than 0.75 indicate a good predictive performance. ROC, receiver operating curve; eGFR, estimated glomerular filtration rate; T2D, type 2 diabetes; AUC, area under the curve.