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Table 1 Characteristics and outcomes of participants categorized by TyG index

From: Association between triglyceride-glucose index and in-hospital mortality in critically ill patients with sepsis: analysis of the MIMIC-IV database

TyG index tertile

T1 (8.13–8.91) N = 473

T2 (8.91–9.5)2 N = 415

T3 (9.52–10.96) N = 369

p-value

Demographic

    

 Age

66.12 (17.73)

62.45 (16.75)

57.90 (16.17)

< 0.001

 Gender(male)

259 (54.76%)

226 (54.46%)

230 (62.33%)

0.042

 BMI

28.53 (5.95)

29.58 (6.99)

30.89 (6.52)

< 0.001

Laboratory tests

    

 Hemoglobin (g/dL)

10.93 (2.42)

10.55 (2.46)

10.55 (2.42)

0.029

 Platelets (K/uL)

176.00 (126.00–226.00)

185.00 (119.00–237.50)

161.00 (95.00–226.00)

0.005

 WBC (K/uL)

12.40 (9.30–16.20)

14.10 (10.50–18.20)

15.80 (11.20–21.30)

< 0.001

 MCV (fL)

90.91 (6.63)

90.55 (7.58)

89.70 (7.12)

0.045

 RDW (%)

15.19 (2.75)

15.43 (2.63)

15.24 (2.32)

0.345

 TC (mg/dL)

143.20 (43.73)

142.27 (42.62)

148.20 (46.81)

0.134

 HDL (mg/dL)

46.47 (16.64)

39.83 (14.44)

35.52 (13.01)

< 0.001

 LDL (mg/dL)

78.39 (33.25)

77.49 (34.35)

77.50 (34.56)

0.902

 Albumin (g/dL)

3.48 (0.56)

3.39 (0.60)

3.20 (0.68)

< 0.001

 Anion gap (mEq/L)

16.71 (4.38)

17.88 (4.82)

19.72 (6.48)

< 0.001

 Bicarbonate (mEq/L)

24.46 (4.15)

23.79 (4.38)

23.22 (4.94)

< 0.001

 BUN (mg/dL)

20.00 (14.00–32.00)

23.00 (17.00–34.00)

27.00 (17.00–45.00)

< 0.001

 Calcium (mg/dL)

8.69 (0.84)

8.68 (0.85)

8.57 (0.98)

0.087

 Chloride (mEq/L)

105.82 (6.06)

106.79 (6.02)

106.67 (7.40)

0.053

 Creatinine (mg/dL)

1.10 (0.80–1.40)

1.20 (0.90–1.80)

1.50 (1.00–2.40)

< 0.001

 Sodium (mEq/L)

140.58 (4.77)

141.18 (5.05)

141.08 (6.13)

0.19

 Potassium (mEq/L)

4.45 (0.76)

4.63 (0.92)

4.76 (0.89)

< 0.001

 Alk. Phosphatase (U/L)

75.11 (62.00–104.04)

76.00 (61.00–103.85)

77.37 (59.00–111.47)

0.062

 CRP (mg/dL)

13.70 (4.00–46.70)

40.80 (7.55–111.45)

88.85 (37.72–153.03)

0.002

 INR

1.30 (1.10–1.60)

1.30 (1.20–1.65)

1.30 (1.10–1.60)

0.573

 PT

4.20 (12.40–17.60)

14.40 (12.80–17.95)

14.20 (12.60–17.70)

0.511

 APTT

33.10 (27.80–46.90)

33.30 (28.35–46.70)

32.90 (27.60–51.30)

0.332

 ALT (U/L)

31.00 (19.00–78.00)

352.48 (1629.12)

59.00 (29.00–220.00)

0.033

 ALP (U/L)

80.00 (66.00–112.90)

83.00 (65.50–118.00)

87.00 (67.00–138.00)

0.004

 AST (U/L)

47.00 (27.00–118.00)

68.00 (31.74–184.50)

100.68 (40.00–396.00)

< 0.001

 Total Bilirubin (mg/dL)

0.80 (0.54–1.40)

0.80 (0.50–1.60)

0.90 (0.50–1.90)

0.28

 NLR

8.43 (4.65–14.87)

9.22 (5.24–15.10)

9.92 (5.86–18.38)

0.019

Comorbidities

    

 Hypertension

211 (44.61%)

184 (44.34%)

139 (37.67%)

0.084

 Myocardial Infarction

95 (20.08%)

104 (25.06%)

75 (20.33%)

0.144

 CHF

140 (29.60%)

125 (30.12%)

91 (24.66%)

0.176

 COPD

62 (13.11%)

59 (14.22%)

55 (14.91%)

0.748

 CAD

108 (22.83%)

111 (26.75%)

76 (20.60%)

0.117

 Atrial Fibrillation

179 (37.84%)

122 (29.40%)

87 (23.58%)

< 0.001

 Renal Failure

68 (14.38%)

68 (16.39%)

61 (16.53%)

0.617

 Chronic Liver Disease

44 (9.30%)

50 (12.05%)

47 (12.74%)

0.236

 Stroke

114 (24.10%)

82 (19.76%)

66 (17.89%)

0.071

 Malignancy

80 (16.91%)

56 (13.49%)

69 (18.70%)

0.13

 Low_HDL

185 (39.11%)

232 (55.90%)

250 (67.75%)

< 0.001

 AKI_48hr

290 (61.31%)

299 (72.05%)

285 (77.24%)

< 0.001

SOFA

5.00 (4.00–8.00)

6.00 (4.00–10.00)

8.00 (5.00–12.00)

< 0.001

Organ dysfunction

    

 Cardiovascular

1.00 (1.00–1.00)

1.00 (1.00–3.00)

1.00 (1.00–4.00)

< 0.001

 Neurologic

2.00 (1.00–3.00)

2.00 (1.00–3.00)

2.00 (0.00–3.00)

0.279

 Coagulation

0.00 (0.00–1.00)

0.00 (0.00–1.00)

0.00 (0.00–2.00)

< 0.001

 Hepatic

0.00 (0.00–1.00)

0.00 (0.00–1.00)

0.00 (0.00–2.00)

0.026

 Kidney

0.00 (0.00–1.00)

1.00 (0.00–1.00)

1.00 (0.00–3.00)

< 0.001

 Respiratory

2.00 (1.00–3.00)

2.00 (1.00–3.00)

3.00 (2.00–4.00)

< 0.001

Outcomes

    

 In-hospital mortality

101 (21.35%)

64 (15.42%)

104 (28.18%)

< 0.001

 ICU-mortality

68 (14.38%)

43 (10.36%)

83 (22.49%)

< 0.001

 28-Day mortality

134 (28.33%)

80 (19.28%)

115 (31.17%)

< 0.001

 Icu_Los_Day

4.00 (2.00–8.00)

5.00 (3.00–9.00)

48

0.044

 Hospital_Los_Day

10.00 (6.00–16.00)

12.00 (6.00–20.00)

10.00 (5.00–19.00)

0.003

  1. Data: N (%) or Mean (Q1–Q3) or mean ± standard deviation
  2. BMI: Body Mass Index; WBC: White Blood Cell; MCV: Mean cell Volume; RDW: Red Cell Distribution Width; TC: Total Cholesterol; HDL: High-Density Lipoprotein; LDL: Low-Density Lipoprotein; BUN: Blood Urea Nitrogen; Alk. Phosphatase: Alkaline Phosphatase; INR: International Normalized Ratio; PT: Prothrombin Time; APTT: Activated Partial Thromboplastin Time; ALT: Alanine Aminotransferase; ALP: Alkaline Phosphatase; AST: Aspartate Aminotransferase; NLR: Neutrophil-to-Lymphocyte Ratio; CHF: Congestive Heart Failure; COPD: Chronic Obstructive Pulmonary Disease; CAD: Coronary Artery Disease; Low_HDL: Low High-Density Lipoprotein; AKI_48hr: Acute Kidney Injury within 48 h; CRP: C-Reactive Protein; SOFA: Sequential Organ Failure Assessment; ICU_Los_Day: Intensive Care Unit Length of Stay; Hospital_Los_Day: Hospital Length of Stay
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Cardiovascular Diabetology

ISSN: 1475-2840