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Fig. 2 | Cardiovascular Diabetology

Fig. 2

From: Non-coding RNA-mediated endothelial-to-mesenchymal transition in human diabetic cardiomyopathy, potential regulation by DNA methylation

Fig. 2

Diabetes is associated with upregulation of pro-EndMT lncRNAs and downregulation of anti-EndMT miRNAs in cardiac tissues. Expressions of anti-EndMT miRNAs A miR-9, B miR-146a, and C miR-200b were significantly lower in the hearts of diabetic compared to non-diabetic patients. Expressions of pro-EndMT lncRNAs D ZFAS1 and E MALAT1 were significantly higher in the hearts of diabetic compared to non-diabetic patients. [miRNA expressions normalized to U6 small nuclear RNA; lncRNA expressions normalized to ACTB mRNA; n = 10 for non-diabetic, n = 28 for diabetic; data presented as scatter plots with mean ± standard deviation; * = p < 0.05, ** = p < 0.01, *** = p < 0.001 as determined by Student’s T-test]

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Cardiovascular Diabetology

ISSN: 1475-2840