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Table 4 Discrimination and reclassification performance of stress hyperglycemia ratio (SHR) in predicting outcomes According to diabetes status

From: Predictive value of the stress hyperglycemia ratio in dialysis patients with acute coronary syndrome: insights from a multi-center observational study

 

C-statistic

(95% CI)

ΔC-statistic

(95% CI)

P Value

Continuous NRI

(95% CI)

P Value

IDI

(95% CI)

P Value

Prediction for MACE in diabetic patients

      

GRACE score

0.597 (0.556, 0.638)

Reference

 

Reference

 

Reference

 

GRACE score + ABG

0.601 (0.560, 0.642)

0.003 (-0.006, 0.012)

0.514

-0.019 (-0.185, 0.151)

0.891

0.003 (-0.002, 0.019)

0.396

GRACE score + SHR (as continuous variable)

0.622 (0.581, 0.663)

0.024 (-0.005, 0.054)

0.101

0.173 (0.011, 0.355)

0.030

0.030 (-0.002, 0.068)

0.090

GRACE score + SHR (> 1.08)

0.627 (0.588, 0.666)

0.030 (0.001, 0.059)

0.045

0.206 (0.071, 0.429)

< 0.001

0.061 (0.013, 0.129)

< 0.001

Prediction for all-cause mortality in diabetic patients

      

GRACE score

0.612 (0.567, 0.657)

Reference

 

Reference

 

Reference

 

GRACE score + ABG

0.625 (0.580, 0.670)

0.013 (-0.006, 0.032)

0.167

0.061 (-0.131, 0.215)

0.428

0.012 (-0.002, 0.039)

0.149

GRACE score + SHR (as continuous variable)

0.653 (0.608, 0.698)

0.042 (0.007, 0.076)

0.019

0.223 (0.047, 0.360)

< 0.001

0.043 (0.003, 0.099)

0.020

GRACE score + SHR (> 1.08)

0.651 (0.608, 0.694)

0.039 (0.007, 0.071)

0.017

0.218 (0.082, 0.342)

< 0.001

0.037 (0.004, 0.085)

< 0.001

Prediction for cardiovascular mortality in diabetic patients

      

GRACE score

0.620 (0.567, 0.673)

Reference

 

Reference

 

Reference

 

GRACE score + ABG

0.630 (0.577, 0.683)

0.01 (-0.010, 0.029)

0.325

0.076 (-0.130, 0.258)

0.388

0.013 (-0.002, 0.048)

0.169

GRACE score + SHR (as continuous variable)

0.664 (0.613, 0.715)

0.045 (0.004, 0.086)

0.033

0.267 (0.097, 0.430)

< 0.001

0.056 (0.002, 0.126)

0.040

GRACE score + SHR (> 1.08)

0.671 (0.622, 0.720)

0.052 (0.012, 0.091)

0.010

0.268 (0.129, 0.395)

< 0.001

0.052 (0.007, 0.116)

0.010

Prediction for MACE in nondiabetic patients

      

GRACE score

0.620 (0.565, 0.675)

Reference

 

Reference

 

Reference

 

GRACE score + ABG

0.635 (0.582, 0.688)

0.016 (-0.005, 0.036)

0.133

-0.064 (-0.213, 0.270)

0.871

0.002 (-0.009, 0.037)

0.634

GRACE score + SHR (as continuous variable)

0.649 (0.596, 0.702)

0.030 (-0.002, 0.061)

0.065

0.053 (-0.195, 0.266)

0.478

0.009 (-0.016, 0.052)

0.637

GRACE score + SHR (> 1.08)

0.640 (0.587, 0.693)

0.020 (-0.010, 0.049)

0.188

0.165 (-0.063, 0.333)

0.159

0.014 (-0.007, 0.075)

0.338

Prediction for all-cause mortality in nondiabetic patients

      

GRACE score

0.659 (0.598, 0.720)

Reference

 

Reference

 

Reference

 

GRACE score + ABG

0.678 (0.617, 0.739)

0.018 (-0.006, 0.042)

0.144

0.019 (-0.166, 0.140)

0.909

0.011 (-0.009, 0.022)

0.545

GRACE score + SHR (as continuous variable)

0.695 (0.636, 0.754)

0.035 (0, 0.071)

0.050

0.045 (-0.113, 0.331)

0.368

0.021 (-0.012, 0.091)

0.368

GRACE score + SHR (> 1.08)

0.682 (0.625, 0.739)

0.023 (-0.010, 0.057)

0.177

0.207 (-0.001, 0.407)

0.060

0.016 (-0.012, 0.086)

0.398

Prediction for cardiovascular mortality in nondiabetic patients

     

GRACE score

0.642 (0.571, 0.713)

Reference

 

Reference

 

Reference

 

GRACE score + ABG

0.670 (0.599, 0.741)

0.028 (-0.007, 0.063)

0.117

0.022 (-0.329, 0.277)

0.786

0.020 (-0.034, 0.111)

0.229

GRACE score + SHR (as continuous variable)

0.691 (0.622, 0.760)

0.049 (-0.001, 0.099)

0.054

0.111 (-0.135, 0.451)

0.289

0.030 (-0.022, 0.158)

0.358

GRACE score + SHR (> 1.08)

0.678 (0.611, 0.745)

0.036 (-0.008, 0.080)

0.107

0.231 (-0.134, 0.514)

0.129

0.021 (-0.054, 0.143)

0.418

  1. ABG = admission blood glucose; CI = confidence interval; GRACE = Global Registry of Acute Coronary Events; IDI = integrated discrimination improvement; MACE = Major Adverse Cardiovascular Events; NRI = net reclassification improvement; SHR = stress hyperglycemia ratio
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Cardiovascular Diabetology

ISSN: 1475-2840