Predictive value of the stress hyperglycemia ratio in dialysis patients with acute coronary syndrome: insights from a multi-center observational study

Table 3 Added predictive ability and reclassification statistics of stress hyperglycemia ratio (SHR) as a continuous or categorical variable

	C-statistic (95% CI)	ΔC-statistic (95% CI)	P Value	Continuous NRI (95% CI)	P Value	IDI (95% CI)	P Value
MACE
GRACE score	0.606 (0.573, 0.639)	Reference		Reference		Reference
GRACE score + ABG	0.613 (0.580, 0.646)	0.006 (-0.003, 0.016)	0.174	0.092 (-0.067, 0.222)	0.259	0.005 (-0.002, 0.021)	0.289
GRACE score + SHR (as continuous variable)	0.635 (0.604, 0.666)	0.028 (0.007, 0.050)	0.010	0.128 (0.008, 0.249)	0.040	0.024 (0.001, 0.053)	0.040
GRACE score + SHR (> 1.08)	0.633 (0.602, 0.664)	0.027 (0.006, 0.048)	0.012	0.212 (0.116, 0.303)	< 0.001	0.028 (0.006, 0.055)	< 0.001
All-cause mortality
GRACE score	0.629 (0.594, 0.664)	Reference		Reference		Reference
GRACE score + ABG	0.643 (0.608, 0.678)	0.014 (0, 0.028)	0.052	0.135 (0.011, 0.255)	0.030	0.013 (0.000, 0.033)	0.070
GRACE score + SHR (as continuous variable)	0.670 (0.635, 0.705)	0.041 (0.015, 0.066)	0.002	0.154 (0.036, 0.277)	0.020	0.038 (0.005, 0.074)	< 0.001
GRACE score + SHR (> 1.08)	0.662 (0.627, 0.697)	0.033 (0.010, 0.057)	0.006	0.216 (0.104, 0.307)	< 0.001	0.031 (0.006, 0.065)	0.010
Cardiovascular mortality
GRACE score	0.628 (0.587, 0.669)	Reference		Reference		Reference
GRACE score + ABG	0.641 (0.600, 0.682)	0.013 (-0.003, 0.028)	0.104	0.146 (0.017, 0.299)	0.020	0.013 (0.000, 0.037)	0.040
GRACE score + SHR (as continuous variable)	0.674 (0.633, 0.715)	0.046 (0.015, 0.078)	0.004	0.239 (0.097, 0.357)	< 0.001	0.049 (0.010, 0.094)	< 0.001
GRACE score + SHR (> 1.08)	0.674 (0.635, 0.713)	0.046 (0.017, 0.076)	0.002	0.256 (0.159, 0.371)	< 0.001	0.042 (0.012, 0.081)	< 0.001

ABG = admission blood glucose; CI = confidence interval; GRACE = Global Registry of Acute Coronary Events; IDI = integrated discrimination improvement; NRI = net reclassification improvement; SHR = stress hyperglycemia ratio

ISSN: 1475-2840