Table 2 Clinical and biological characteristics according to the Gensini score tertiles and degree of CAD
Variable | Gensini score tertiles | Degree of CAD | |||||||
|---|---|---|---|---|---|---|---|---|---|
Lowest tertile ≤ 32 (n = 114) | Mid tertile 32 ~ 53 (n = 100) | Highest tertile ≥ 53 (n = 106) | p value | Non-severe stenosis (n = 214) | Sever stenosis (n = 106) | p value | |||
TyG index | 8.47 ± 0.51 | 8.94 ± 0.69 | 9.48 ± 0.86 |  < 0.001 | 8.7 ± 0.6 | 9.5 ± 0.9 |  < 0.001 | ||
Age, years | 65.0 ± 10.6 | 67.0 ± 10.0 | 65.8 ± 10.3 | 0.165 | 67.3 ± 10.3 | 65.7 ± 10.6 | 0.181 | ||
Male | 53 (46.5) | 54 (54.0) | 55 (51.9) | 0.521 | 107 (50.0) | 55 (51.9) | 0.751 | ||
BMI, kg/m2 | 23.1 ± 3.1 | 24.4 ± 3.6 | 24.3 ± 2.7 | 0.005 | 23.7 ± 3.4 | 24.3 ± 2.7 | 0.136 | ||
SBP, mmHg | 141.2 ± 28.0 | 138.2 ± 20.1 | 139.8 ± 20.4 | 0.784 | 139.8 ± 24.6 | 139.8 ± 20.4 | 0.998 | ||
DBP, mmHg | 81.6 ± 15.4 | 82.5 ± 11.8 | 81.4 ± 11.4 | 0.567 | 82.0 ± 13.8 | 81.4 ± 11.4 | 0.698 | ||
Heart rate, bpm | 75.5 ± 15.0 | 77.0 ± 13.2 | 77.3 ± 13.9 | 0.536 | 76.2 ± 14.2 | 77.3 ± 13.9 | 0.521 | ||
Smoker | 9 (7.9) | 30 (30.0) | 49 (46.2) |  < 0.001 | 39 (18.2) | 49 (46.2) |  < 0.001 | ||
Drinker | 2 (1.8) | 7 (7.0) | 19 (17.9) |  < 0.001 | 9 (4.2) | 19 (17.9) |  < 0.001 | ||
H-type hypertension | 34 (29.8) | 53 (53.0) | 67 (63.2) |  < 0.001 | 87 (40.7) | 67 (63.2) |  < 0.001 | ||
METS-IR index | 34.2 ± 6.0 | 38.5 ± 7.9 | 41.3 ± 8.1 | 0.067 | 36.2 ± 7.3 | 41.3 ± 8.1 |  < 0.001 | ||
Metabolic syndrome | 2 (1.8) | 6 (6.0) | 38 (35.8) |  < 0.001 | 8 (3.7) | 38 (35.8) |  < 0.001 | ||
Diabetes mellitus | 20 (17.5) | 33 (33.0) | 42 (39.6) | 0.001 | 53 (24.8) | 42 (39.6) | 0.006 | ||
Biochemical indicators | |||||||||
 WBC, 109/L | 6.0 ± 2.0 | 6.5 ± 2.0 | 6.6 ± 2.2 | 0.065 | 6.3 ± 2.0 | 6.6 ± 2.2 | 0.130 | ||
 Neutrophil ratio, % | 65.8 ± 10.8 | 66.5 ± 9.6 | 66.3 ± 10.2 | 0.819 | 66.1 ± 10.2 | 66.6 ± 10.1 | 0.702 | ||
 Platelet, 109/L | 211.2 ± 62.2 | 225.7 ± 65.9 | 211.3 ± 55.4 | 0.153 | 218.0 ± 64.2 | 211.3 ± 55.4 | 0.357 | ||
 Albumin, g/L | 41.6 ± 3.7 | 41.9 ± 3.6 | 41.6 ± 4.1 | 0.083 | 41.8 ± 3.7 | 41.6 ± 4.1 | 0.646 | ||
 Homocysteine | 16.4 ± 8.4 | 18.4 ± 8.1 | 17.8 ± 6.0 |  < 0.001 | 17.3 ± 8.3 | 17.8 ± 6.0 | 0.078 | ||
 FPG,mg/dl | 111.2 ± 29.3 | 140.4 ± 64.5 | 168.7 ± 82.2 |  < 0.001 | 124.8 ± 51.1 | 168.7 ± 82.2 |  < 0.001 | ||
 TC, mg/dl | 155.7 ± 42.8 | 158.5 ± 44.7 | 170.2 ± 51.1 | 0.051 | 157.0 ± 43.6 | 170.2 ± 51.1 | 0.017 | ||
 TG, mg/dl | 98.3 ± 47.8 | 1138.3 ± 87.2 | 219.0 ± 246.8 |  < 0.001 | 117.0 ± 71.7 | 219.0 ± 246.8 |  < 0.001 | ||
 HDL-C, mg/dl | 52.7 ± 15.0 | 47.5 ± 12.8 | 42.6 ± 13.7 |  < 0.001 | 50.3 ± 14.2 | 42.6 ± 13.7 |  < 0.001 | ||
 LDL-C, mg/dl | 83.3 ± 33.5 | 86.0 ± 36.4 | 95.2 ± 40.3 | 0.047 | 84.6 ± 34.8 | 95.2 ± 40.3 | 0.016 | ||
 Uric acid, mg/dl | 6.2 ± 1.8 | 6.3 ± 2.1 | 6.8 ± 1.8 | 0.047 | 6.2 ± 2.0 | 6.8 ± 1.8 | 0.015 | ||
 SCr, umol/L | 85.4 ± 49.9 | 77.7 ± 37.6 | 82.4 ± 37.7 | 0.064 | 81.8 ± 44.7 | 82.4 ± 37.7 | 0.908 | ||
Coronary angiography | |||||||||
 Lesion vessels | 0.6 ± 1.0 | 1.1 ± 1.1 | 1.7 ± 1.2 |  < 0.001 |  |  |  | ||
 Three-vessel disease | 28(24.6) | 47(47.0) | 75(70.8) |  < 0.001 |  |  |  | ||
 Gensini score, (IQR) | 23.5 ± 4.3 | 41.9 ± 5.8 | 88.5 ± 34.1 |  < 0.001 |  |  |  | ||
Medication, n (%) | |||||||||
 Antiplatelet | 23 (20.2) | 18 (18.0) | 25 (23.6) | 0.606 | 41 (19.2) | 25 (23.6) | 0.357 | ||
 Statin | 10 (8.8) | 10(10.0) | 11 (104) | 0.915 | 20 (9.3) | 11 (10.4) | 0.769 | ||
 CCB | 25 (21.9) | 20 (20.0) | 14 (13.2) | 0.221 | 45 (21.0) | 14 (13.2) | 0.090 | ||
 Beta blockers | 11 (9.6) | 7 (7.0) | 13 (12.3) | 0.443 | 18 (8.4) | 13 (12.3) | 0.273 | ||
 ACEI/ARB | 17 (14.9) | 5 (5.0) | 1 (0.9) |  < 0.001 | 22 (10.3) | 1 (0.9) | 0.002 | ||