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Table 2 Characteristics of participants without diabetes (n = 5934) according to quintiles of eGFR slopes at index date*

From: Association between estimated glomerular filtration rate slope and cardiovascular disease among individuals with and without diabetes: a prospective cohort study

Characteristics

Quintile 1

(n = 1187)

Quintile 2

(n = 1187)

Quintile 3

(n = 1187)

Quintile 4

(n = 1187)

Quintile 5

(n = 1186)

P value

P trend

Slope range (ml/min per 1.73 m2 per year)

(-1.15, -0.82)

(-0.82, -0.74)

(-0.74, -0.67)

(-0.67, -0.59)

(-0.59, -0.01)

  

Slop, mean (SD)

-0.89 (0.06)

-0.78 (0.02)

-0.71 (0.02)

-0.63 (0.02)

-0.49 (0.08)

< 0.001

< 0.001

Age, mean (SD)

37.2 (7.0)

42.1 (8.7)

45.7 (9.5)

51.2 (10.5)

59.8 (11.5)

< 0.001

< 0.001

Female sex, n (%)

757 (63.8)

827 (69.7)

764 (64.4)

705 (59.4)

369 (31.1)

< 0.001

< 0.001

Educational level, n (%)

       

 < 6 years

83 (7.0)

145 (12.2)

195 (16.4)

323 (27.2)

457 (38.5)

< 0.001

< 0.001

 6–12 years

762 (64.2)

714 (60.2)

714 (60.2)

647 (54.5)

526 (44.4)

< 0.001

 > 12 years

342 (28.8)

328 (27.6)

278 (23.4)

217 (18.3)

203 (17.1)

< 0.001

Marital status, n (%)

       

 Single

152 (12.8)

100 (8.4)

85 (7.2)

50 (4.2)

30 (2.5)

< 0.001

< 0.001

 Married

1006 (84.8)

1036 (87.3)

1033 (87.0)

1027 (86.5)

1008 (85.0)

0.931

 Widowed/Divorced

29 (2.4)

51 (4.3)

69 (5.8)

110 (9.3)

148 (12.5)

< 0.001

Smoking status, n (%)

       

 Never smoker

864 (72.8)

941 (79.3)

900 (75.8)

891 (75.1)

779 (65.7)

< 0.001

< 0.001

 Past smoker

58 (4.9)

58 (4.9)

73 (6.1)

90 (7.6)

178 (15.0)

< 0.001

 Current smoker

265 (22.3)

188 (15.8)

214 (18.0)

206 (17.4)

2296 (19.3)

0.206

BMI (kg/m2), mean (SD)

27.2 (4.7)

27.9 (4.8)

28.7 (4.6)

29.0 (4.5)

28.0 (4.3)

< 0.001

< 0.001

SBP (mm Hg), mean (SD)

109.5 (13.6)

111.4 (14.6)

114.8 (15.5)

118.5 (17.2)

124.9 (19.8)

< 0.001

< 0.001

DBP (mm Hg), mean (SD)

74.5 (9.8)

75.7 (10.3)

77.7 (10.8)

78.5 (10.4)

79.6 (11.4)

< 0.001

< 0.001

Fasting plasma glucose (mmol/L), median (IQR)

5.0 (0.56)

5.1 (0.67)

5.2 (0.61)

5.2 (0.67)

5.3 (0.67)

< 0.001

< 0.001

Triglycerides (mmol/L), median (IQR)

1.2 (0.89)

1.2 (0.87)

1.4 (0.99)

1.5 (1.01)

1.5 (0.99)

< 0.001

< 0.001

Total cholesterol (mmol/L), median (IQR)

4.6 (1.1)

4.8 (1.1)

4.9 (1.2)

5.1 (1.3)

5.2 (1.3)

< 0.001

< 0.001

eGFR (ml/min per 1.73 m2), mean (SD)

91.5 (10.8)

83.7 (10.4)

79.2 (10.0)

73.6 (10.1)

66.9 (10.9)

< 0.001

< 0.001

Family history of CVD (yes), n (%)

63 (5.3)

72 (6.1)

64 (5.4)

80 (6.7)

46 (3.9)

0.034

0.296

Hypertension, (yes), n (%)

406 (34.2)

470 (39.6)

562 (47.3)

634 (53.4)

751 (63.3)

< 0.001

< 0.001

RAAS-I drugs, (yes), n (%)

8 (0.7)

21 (1.8)

24 (2.0)

53 (4.5)

74 (6.2)

< 0.001

< 0.001

  1. *The characteristics were measured at the index date (Phase 4).
  2. eGFR: estimated glomerular filtration rate; SD: standard deviation; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; CVD: cardiovascular disease; IQR: interquartile range; RAAS-I: renin-angiotensin-aldosterone system inhibitors
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Cardiovascular Diabetology

ISSN: 1475-2840