Fig. 2
Spline curves showing log relative hazard (HRs) and 95%CIs (shaded) for CVD among individuals with diabetes. Knots were placed at the 5th, 25th, 50th, 75th, and 95th percentiles of the eGFR slope. The model was adjusted for the following variables (set at representative levels): sex (female), age (58 years), BMI (29.43 kg/m2), smoking status (never), hypertension (yes), hypercholesterolemia (yes), FH-CVD (no), marital status (married), education level (< 6 years), FPG (143 mg/dl), eGFR at index date (71.3) and glucose-lowering drugs (yes), RAAS-I drugs = no, NPDR = no. HR: hazard ratio; eGFR: estimated glomerular filtration rate; CI: confidence interval; BMI: body mass index; FH-CVD: family history of CVD; FPG: fasting blood glucose; RAAS-I: renin-angiotensin-aldosterone system inhibitors; NPDR/PDR: non-proliferative and proliferative diabetic retinopathy