Association between high sensitivity cardiac troponin and mortality risk in the non-diabetic population: findings from the National Health and Nutrition Examination Survey

Table 3 Interaction analysis for the relationship between Hs-cTn concentration and mortality

	Hazard ratio (95% confidence interval)			P value for interaction
	< LOD	LOD–99th URL	≥ 99th URL	P value for interaction
All-cause mortality
Hs-cTnI
Normoglycemia	Ref	1.14 (0.93, 1.40)	1.41 (0.95, 2.10)	0.009
Prediabetes	Ref	0.97 (0.72, 1.29)	2.27 (1.44, 3.58)	0.009
Hs-cTnT
Normoglycemia	Ref	1.12 (0.78, 1.61)	2.23 (1.48, 3.35)	0.64
Prediabetes	Ref	0.89 (0.45, 1.77)	1.67 (0.82, 3.39)	0.64
Cardiovascular mortality
Hs-cTnI
Normoglycemia	Ref	1.28 (0.83, 1.98)	1.72 (0.85, 3.48)	0.04
Prediabetes	Ref	0.87 (0.50, 1.49)	2.55 (1.20, 5.42)	0.04
Hs-cTnT
Normoglycemia	Ref	1.48 (0.59, 3.73)	3.23 (1.22, 8.56)	0.58
Prediabetes	Ref	0.80 (0.20, 3.18)	1.98 (0.49, 8.02)	0.58

Model adjusted for age, sex, race, current smoker, systolic blood pressure, diastolic blood pressure, body mass index, total cholesterol, high-density lipid cholesterol, estimated glomerular filtration rate, antihypertensive medication use, antiplatelet medication use and statin use
Hs high sensitivity, cTnT cardiac Troponin T, cTnI cardiac Troponin I, LOD limits of detection, 99th URL 99th percentile upper reference limit

ISSN: 1475-2840