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Table 3 Characteristics of subjects by the trajectories of TyG index from 2011 to 2020 (n = 1821)

From: Association of triglyceride-glucose index trajectory and frailty in urban older residents: evidence from the 10-year follow-up in a cohort study

Variables

Low-stable

(N = 697)

Moderate-stable

(N = 910)

High-stable (N = 214)

P value

General Characteristics

    

Age, mean (SD)

71.5 ± 6.1

71.4 ± 6.3

71.3 ± 6.0

0.83

Male (%)

280 (41.4%)

382 (40.9%)

83 (39.5%)

0.89

Smoking (%)

99 (14.6%)

164 (17.6%)

32 (15.2%)

0.27

Drinking (%)

92 (13.6%)

143 (15.3%)

37 (17.6%)

0.32

Regular exercise (%)

168 (24.8%)

231 (24.7%)

63 (30.0%)

0.26

Education (primary school or below, N, %)

131 (19.4%)

173 (18.5%)

40 (19.0%)

0.91

Income (< 3000 RMB per month, N, %)

255 (37.7%)

313 (33.5%)

74 (35.2%)

0.23

Medical history & Medication

   

MNA-SF score

12 (11, 14)

13 (12, 14)

13 (12, 14)

< 0.001

Hypertension (%)

342 (50.5%)

628 (67.2%)

159 (75.7%)

< 0.001

Diabetes (%)

126 (18.6%)

332 (35.5%)

129 (61.4%)

< 0.001

Comorbidities (%)

303 (44.8%)

570 (61.0%)

162 (77.1%)

< 0.001

Polypharmacy (%)

130 (19.2%)

274 (29.3%)

94 (44.8%)

< 0.001

Antihypertensive agents (%)

310 (45.8%)

574 (61.5%)

155 (73.8%)

< 0.001

Hypoglycemic agents (%)

86 (12.7%)

240 (25.7%)

97 (46.2%)

< 0.001

Lipid-lowering agents (%)

143 (21.1%)

276 (29.6%)

85 (40.5%)

< 0.001

Cognitive impairment (N, %)

92 (13.6%)

153 (16.4%)

21 (10.0%)

0.061

Frailty index (median, IQR)

0.12 (0.07, 0.17)

0.13 (0.09, 0.18)

0.15 (0.10, 0.20)

< 0.001

Physical Exam & Laboratory data

   

TUG (seconds)

10.0 (9.0, 11.7)

10.2 (9.0, 11.5)

10.5 (9.5, 11.9)

0.012

Low grip strength (N, %)

242 (35.7%)

291 (31.2%)

73 (34.8%)

0.14

Slow gait speed (N, %)

71 (10.5%)

87 (9.3%)

26 (12.4%)

0.38

BMI (kg/m2)

24 (21.6, 25.8)

24.9 (23.1, 26.8)

25.4 (23.6, 27.4)

< 0.001

SBP (mmHg)

134 (123, 144)

138 (128, 149)

141.5 (131, 154)

< 0.001

DBP (mmHg)

80 (72, 87)

81 (75, 88)

83 (75, 91)

< 0.001

HDL-C (mmol/L)

1.3 (1.1, 1.5)

1.1 (1.0, 1.3)

1.1 (0.9, 1.2)

< 0.001

LDL-C (mmol/L)

2.7 (2.0, 3.3)

2.8 (2.2, 3.5)

2.6 (1.9, 3.3)

< 0.001

TC (mmol/L)

5.2 (4.4, 5.9)

5.4 (4.6, 6.2)

5.3 (4.6, 6.3)

0.014

TG (mmol/L)

1.0 (0.8, 1.2)

1.7 (1.3, 2.1)

3.0 (2.3, 4.0)

< 0.001

FPG (mmol/L)

5.6 (5.3, 6.1)

6.1 (5.6, 7)

7.1 (6.1, 9.1)

< 0.001

HbA1c (%)

5.6 (5.2, 5.9)

5.8 (5.4, 6.5)

6.5 (5.8, 7.5)

< 0.001

  1. MNA-SF: mini-nutritional assessment-short form, BMI: body mass index, SBP: systolic blood pressure, DBP: diastolic blood pressure, HDL-C: high-density lipoprotein cholesterol, LDL-C: low-density lipoprotein cholesterol, TC: total cholesterol, TG: triglycerides, FPG: fasting plasma glucose, HbA1c: hemoglobin A1c. Comorbidity was defined as the coexistence of ≥ 2 chronic conditions, polypharmacy as the use of ≥ 5 categories of medication
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Cardiovascular Diabetology

ISSN: 1475-2840