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Table 2 Associations between SDF-1 quartiles and stroke outcomes according to diabetes status

From: Prognostic significance of plasma SDF-1 in acute ischemic stroke patients with diabetes mellitus: the CATIS trial

 

SDF-1, pg/mL

 

Each 1-SD increase

 

Q1

Q2

Q3

Q4

P trend

Ischemic stroke patients with diabetes

   

Recurrent stroke at 1 year

      

Events, n (%)

4 (2.4)

6 (4.1)

8 (6.4)

12 (9.5)

   

Model 1

1.00

1.72 (0.49–6.10)

2.60 (0.78–8.68)

4.00 (1.29–12.41)

0.008

1.67 (1.18–2.35)

 

Model 2

1.00

1.79 (0.51–6.35)

2.65 (0.79–8.89)

4.16 (1.34–12.94)

0.007

1.65 (1.18–2.31)

 

Model 3

1.00

1.75 (0.49–6.21)

2.76 (0.81–9.38)

4.12 (1.31–12.95)

0.007

1.65 (1.18–2.32)

 

Cardiovascular events at 1 year

      

Events, n (%)

7 (4.2)

9 (6.1)

12 (9.5)

14 (11.0)

   

Model 1

1.00

1.48 (0.55–3.98)

2.18 (0.86–5.57)

2.64 (1.06–6.54)

0.02

1.43 (1.06–1.93)

 

Model 2

1.00

1.51 (0.56–4.06)

2.21 (0.86–5.64)

2.68 (1.08–6.66)

0.02

1.43 (1.06–1.93)

 

Model 3

1.00

1.46 (0.54–3.92)

2.23 (0.86–5.79)

2.80 (1.11–7.06)

0.02

1.47 (1.08–1.99)

 

All-cause mortality at 1 year

      

Events, n (%)

9 (5.4)

8 (5.4)

9 (7.1)

14 (11.0)

   

Model 1

1.00

1.02 (0.39–2.65)

1.28 (0.51–3.25)

1.94 (0.84–4.48)

0.09

1.27 (0.92–1.74)

 

Model 2

1.00

1.00 (0.39–2.60)

1.27 (0.50–3.22)

1.89 (0.82–4.39)

0.10

1.26 (0.91–1.73)

 

Model 3

1.00

0.90 (0.35–2.37)

1.36 (0.53–3.53)

2.09 (0.86–5.09)

0.07

1.36 (0.96–1.93)

 

Ischemic stroke patients without diabetes

   

Recurrent Stroke at 1 year

      

Events, n (%)

33 (5.1)

29 (4.3)

25 (3.6)

33 (4.8)

   

Model 1

1.00

0.85 (0.52–1.40)

0.69 (0.41–1.16)

0.90 (0.56–1.47)

0.61

0.92 (0.76–1.11)

 

Model 2

1.00

0.85 (0.52–1.41)

0.70 (0.42–1.18)

0.91 (0.56–1.48)

0.63

0.92 (0.77–1.11)

 

Model 3

1.00

0.85 (0.52–1.40)

0.70 (0.42–1.18)

0.95 (0.58–1.55)

0.77

0.94 (0.78–1.13)

 

Cardiovascular events at 1 year

      

Events, n (%)

43 (6.7)

38 (5.7)

38 (5.5)

35 (5.1)

   

Model 1

1.00

0.86 (0.55–1.32)

0.80 (0.51–1.23)

0.72 (0.46–1.13)

0.15

0.88 (0.74–1.04)

 

Model 2

1.00

0.49 (0.55–1.33)

0.80 (0.52–1.25)

0.73 (0.46–1.14)

0.16

0.88 (0.74–1.04)

 

Model 3

1.00

0.83 (0.54–1.29)

0.79 (0.51–1.22)

0.71 (0.45–1.12)

0.14

0.87 (0.74–1.04)

 

All-cause mortality at 1 year

      

Events, n (%)

35 (5.4)

47 (7.0)

39 (5.7)

43 (6.3)

   

Model 1

1.00

1.32 (0.85–2.04)

0.97 (0.61–1.53)

1.03 (0.66–1.61)

0.11

1.00 (0.86–1.16)

 

Model 2

1.00

1.32 (0.85–2.04)

0.97 (0.61–1.53)

1.04 (0.66–1.62)

0.77

1.00 (0.86–1.17)

 

Model 3

1.00

1.22 (0.79–1.89)

0.93 (0.59–1.48)

0.84 (0.53–1.33)

0.25

0.93 (0.79–1.09)

 
  1. Model 1: adjusted for age, sex
  2. Model 2: further adjusted for medical history (hypertension, hyperlipidemia)
  3. Model 3: further adjusted for current smoking, alcohol consumption, estimated glomerular filtration rate, ischemic stroke subtype, randomized treatment, and baseline NIHSS score
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Cardiovascular Diabetology

ISSN: 1475-2840