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Table 2 Multivariate Cox proportional hazard model for the incidence of conduction disorders

From: Elevated high-sensitivity C-reactive protein levels increase the risk of new-onset cardiac conduction disorders

 

Cases/Total

Incidence/1000-person years

Model 1

HR (95% CI)

Model 2

HR (95%CI)

Model 3

HR (95%CI)

Model 4

HR (95%CI)

Any Cardiac conduction disorder

 hsCRP ≤ 3 mg/L

2674/70002

3.59 (3.46–3.74)

Reference

Reference

Reference

Reference

 hsCRP > 3 mg/L

940/16232

5.60 (5.25–5.97)

1.43 (1.33–1.54)

1.43 (1.32–1.54)

1.41 (1.31–1.53)

1.40 (1.29–1.51)

 log (hsCRP)/SD

3614/86234

3.96 (3.83–4.09)

1.17 (1.13–1.21)

1.15 (1.11–1.19)

1.14 (1.11–1.19)

1.13 (1.10–1.18)

Any Atrioventricular Block

 hsCRP ≤ 3 mg/L

781/70002

1.05 (0.98–1.13)

Reference

Reference

Reference

Reference

 hsCRP > 3 mg/L

340/16232

2.02 (1.82–2.25)

1.74 (1.53–1.98)

1.70 (1.49–1.94)

1.69 (1.48–1.93)

1.64 (1.44–1.87)

 log (hsCRP)/SD

1121/86234

1.23 (1.16–1.30)

1.29 (1.22–1.37)

1.25 (1.18–1.33)

1.24 (1.17–1.33)

1.23 (1.15–1.31)

Any Bundle- branch Block

 hsCRP ≤ 3 mg/L

1921/70002

2.58 (2.47–2.70)

Reference

Reference

Reference

Reference

 hsCRP > 3 mg/L

615/16232

3.66 (3.38–3.96)

1.31 (1.19–1.43)

1.32 (1.20–1.45)

1.31 (1.18–1.43)

1.29 (1.18–1.42)

 log (hsCRP)/SD

2536/86234

2.78 (2.67–2.89)

1.12 (1.08–1.16)

1.11 (1.07–1.16)

1.11 (1.06–1.15)

1.10 (1.06–1.15)

Any Left Bundle- branch Block

 hsCRP ≤ 3 mg/L

744/70002

1.00 (0.93–1.07)

Reference

Reference

Reference

Reference

 hsCRP > 3 mg/L

241/16232

1.43 (1.26–1.63)

1.30 (1.12–1.51)

1.26 (1.08–1.46)

1.26 (1.08–1.46)

1.25 (1.07–1.45)

 log (hsCRP)/SD

985/86234

1.08 (1.02–1.15)

1.07 (1.01–1.14)

1.05 (0.98–1.12)

1.04 (0.98–1.11)

1.04 (0.97–1.11)

Right Bundle- branch Block

 hsCRP ≤ 3 mg/L

1320/70002

1.77 (1.68–1.87)

Reference

Reference

Reference

Reference

 hsCRP > 3 mg/L

420/16232

2.50 (2.27–2.75)

1.31 (1.16–1.46)

1.35 (1.20–1.51)

1.33 (1.18–1.49)

1.31 (1.17–1.47)

 log (hsCRP)/SD

1740/86234

1.90 (1.82–2.00)

1.15 (1.09–1.20)

1.15 (1.09–1.21)

1.14 (1.09–1.20)

1.13 (1.08–1.19)

  1. Model 1: Corrected for age and gender
  2. Model 2: Corrected for baseline body mass index, physical activity, smoking, alcohol consumption, cholesterol, uric acid, estimated glomerular filtration rate, hypertension, diabetes mellitus, and myocardial infarction based on model 1
  3. Model 3: Corrected for new-onset hypertension, diabetes mellitus, and myocardial infarction during the follow-up based on model 2
  4. Model 4: Corrected for those taking antihypertensive, lipid-lowering, and glucose-lowering drugs at baseline or during the follow-up based on model 3
  5. HR, hazard ratio; Log (hsCRP)/SD, log-transformed for each standard deviation increase in hsCRP; CI, confidence interval