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Table 3 Comparison of Model Performance in Predicting All-Cause Mortality

From: Association of cardio-renal biomarkers and mortality in the U.S.: a prospective cohort study

Model

AIC

BIC

Harrell’s C-index

Categorical NRI

Continuous NRI

event NRI

nonevent NRI

IDI

Model 1

12620.09

12652.7

0.726 (0.71,0.742)

-

-

-

-

-

Model 1 + hs-cTnT

11107.78

11145.1

0.757 (0.741,0.773)

0.135 (0.072–0.205)

0.490 (0.338–0.616)

0.123 (0.032–0.198)

0.368 (0.282–0.456)

0.050 (0.030–0.064)

Model 1 + hs-cTnI

11163.33

11200.68

0.747 (0.731,0.763)

0.069 (0.016–0.133)

0.355 (0.271–0.488)

0.092 (0.019–0.170)

0.263 (0.198–0.353)

0.028 (0.014–0.044)

Model 1 + NT-proBNP

11165.26

11202.59

0.754 (0.738,0.771)

0.135 (0.082–0.194)

0.377 (0.265–0.519)

0.150 (0.053–0.232)

0.227 (0.172–0.317)

0.050 (0.025–0.071)

Model 1 + Creatinine

12193.66

12231.53

0.737 (0.721,0.753)

0.050 (-0.007-0.083)

0.191 (0.037–0.324)

-0.053 (-0.126-0.016)

0.243 (0.145–0.342)

0.020 (0.005–0.032)

Model 1 + Cystatin C

11209.89

11247.27

0.751 (0.735,0.767)

0.086 (0.010–0.146)

0.356 (0.194–0.519)

0.050 (-0.053-0.122)

0.306 (0.202–0.445)

0.040 (0.021–0.054)

Model 1 + β-2 microglobulin

11165.04

11202.4

0.754 (0.737,0.77)

0.106 (0.052–0.190)

0.425 (0.295–0.549)

0.052 (-0.026-0.140)

0.373 (0.268–0.477)

0.045 (0.021–0.061)

Model 1 + Plasma glucose

5651.761

5684.978

0.728 (0.706,0.75)

0.061 (-0.044-0.088)

0.110 (-0.038-0.282)

-0.103 (-0.221-0.000)

0.213 (0.129–0.303)

0.001 (-0.007-0.013)

Model 1 + HbA1c

12609.06

12647.11

0.729 (0.713,0.744)

0.053 (-0.028-0.066)

0.123 (0.010–0.277)

-0.087 (-0.165-0.010)

0.210 (0.156–0.288)

0.003 (-0.002-0.009)

Model 1 + Glycated albumin

8747.793

8850.299

0.734 (0.718,0.751)

0.026 (-0.004-0.072)

0.214 (0.094–0.324)

0.000 (-0.084-0.067)

0.214 (0.140–0.292)

0.006 (-0.001-0.014)

Model 2

10125.14

10224.76

 

-

-

-

-

-

Model 2 + hs-cTnT

9249.943

9353.346

0.746 (0.729,0.763)

0.106 (0.059–0.190)

0.564 (0.400-0.669)

0.175 (0.063–0.225)

0.390 (0.298–0.474)

0.043 (0.024–0.058)

Model 2 + hs-cTnI

9302.74

9406.189

0.765 (0.748,0.782)

0.046 (-0.005-0.096)

0.295 (0.148–0.437)

0.039 (-0.061-0.112)

0.256 (0.162–0.383)

0.019 (0.008–0.031)

Model 2 + NT-proBNP

9307.591

9411.009

0.757 (0.74,0.775)

0.086 (0.031–0.145)

0.381 (0.236–0.513)

0.158 (0.072–0.242)

0.222 (0.141–0.313)

0.032 (0.014–0.050)

Model 2 + Creatinine

10108.76

10213.63

0.76 (0.743,0.777)

0.032 (-0.012-0.070)

0.188 (0.028–0.320)

-0.005 (-0.086-0.065)

0.192 (0.089–0.285)

0.010 (-0.001-0.021)

Model 2 + Cystatin C

9347.044

9450.569

0.75 (0.732,0.767)

0.073 (0.013–0.149)

0.357 (0.209–0.529)

0.022 (-0.060-0.132)

0.335 (0.197–0.436)

0.026 (0.006–0.038)

Model 2 + β-2 microglobulin

9307.106

9410.585

0.76 (0.743,0.777)

0.107 (0.023–0.143)

0.413 (0.261–0.559)

0.053 (-0.034-0.149)

0.360 (0.271–0.485)

0.031 (0.007–0.046)

Model 2 + Plasma glucose

4574.251

4665.387

0.762 (0.745,0.78)

0.009 (-0.034-0.084)

0.107 (-0.057-0.330)

-0.080 (-0.163-0.079)

0.188 (0.054-0.300)

0.002 (-0.006-0.017)

Model 2 + HbA1c

10113.25

10218.12

0.758 (0.740–0.775)

0.014 (-0.014-0.062)

0.028 (-0.008-0.085)

0.021 (-0.022-0.063)

0.007 (-0.006-0.027)

0.004 (-0.003-0.012)

Model 2 + Glycated albumin

8697.23

8799.687

0.760 (0.742–0.777)

0.231 (0.088–0.346)

0.207 (-0.003-0.335)

0.000 (-0.140-0.071)

0.207 (0.118–0.303)

0.007 (-0.001-0.016)

  1. Hs-cTnT: high-sensitivity Troponin T; hs-cTnI: high-sensitivity Troponin I; NT-proBNP: N-terminal pro-B-type natriuretic peptid
  2. Model 1: gender, age, race, BMI.
  3. Model 2: gender, age, race, BMI, education, activity, PIR, cotinine, drinking, hypertension, hyperlipidemia, CVD, CKD.
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Cardiovascular Diabetology

ISSN: 1475-2840