Table 2 Association of Bio-markers Levels With All-Cause and Cause-Specific Mortality

hs-cTnT, ng/L

< 6.11

1

1

1

1

1

1

1

1

1

6.11-< 9.92

2.40 (1.88–3.07)

1.43 (1.10–1.86)

1.33 (1.00-1.76)

2.65 (1.56–4.50)

1.57 (0.91–2.73)

1.42 (0.79–2.58)

2.05 (0.98–4.32)

1.78 (0.82–3.88)

1.74 (0.76–3.97)

9.92-< 16.67

4.77 (3.77–6.03)

2.20 (1.69–2.86)

2.00 (1.50–2.65)

6.13 (3.74–10.06)

2.65 (1.54–4.56)

2.26 (1.26–4.03)

4.71 (2.37–9.35)

3.95 (1.85–8.44)

3.11 (1.35–7.14)

≥ 16.67

9.44 (7.50-11.88)

3.68 (2.80–4.84)

3.40 (2.52–4.60)

16.44 (10.21–26.48)

6.24 (3.61–10.81)

5.59 (3.08–10.15)

11.28 (5.82–21.86)

8.70 (4.00-18.91)

7.32 (3.09–17.35)

P trend

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

ln(hs-cTnT), ng/L

2.29 (2.14–2.45)

1.86 (1.69–2.04)

1.81 (1.62–2.03)

2.55 (2.27–2.87)

2.17 (1.85–2.56)

2.07 (1.69–2.54)

2.48 (2.06–2.99)

2.33 (1.84–2.94)

2.31 (1.71–3.12)

hs-cTnI, ng/L

< 1.80

1

1

1

1

1

1

1

1

1

1.80-< 3.10

2.06 (1.64–2.58)

1.25 (0.99–1.58)

1.15 (0.90–1.48)

2.87 (1.72–4.77)

1.69 (1.01–2.84)

1.42 (0.83–2.43)

2.58 (1.37–4.88)

1.88 (0.98–3.62)

1.94 (0.94–3.99)

3.10-< 6.10

3.59 (2.90–4.46)

1.76 (1.39–2.23)

1.62 (1.25–2.10)

5.75 (3.55–9.32)

2.60 (1.56–4.34)

2.07 (1.20–3.55)

3.59 (1.91–6.75)

2.33 (1.19–4.55)

2.20 (1.02–4.76)

≥ 6.10

5.81 (4.70–7.18)

2.41 (1.89–3.06)

1.96 (1.50–2.56)

12.06 (7.57–19.22)

4.57 (2.74–7.61)

2.81 (1.63–4.86)

5.34 (2.86–9.97)

2.97 (1.48–5.96)

2.53 (1.14–5.61)

P trend

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

0.002

0.036

ln(hs-cTnI), ng/L

1.74 (1.65–1.84)

1.41 (1.31–1.52)

1.34 (1.23–1.46)

1.99 (1.82–2.19)

1.67 (1.48–1.89)

1.52 (1.30–1.77)

1.73 (1.47–2.03)

1.47 (1.20–1.80)

1.35 (1.06–1.72)

NT-proBNP, pg/ml

< 35.77

1

1

1

1

1

1

1

1

1

35.77-< 82.82

1.75 (1.38–2.21)

1.28 (1.00-1.63)

1.20 (0.93–1.57)

2.24 (1.37–3.66)

1.71 (1.03–2.82)

1.54 (0.90–2.63)

1.72 (0.85–3.45)

1.33 (0.65–2.73)

1.23 (0.55–2.73)

82.82-< 232.60

3.44 (2.76–4.27)

1.88 (1.48–2.40)

1.73 (1.34–2.25)

3.96 (2.48–6.32)

2.37 (1.43–3.93)

2.15 (1.27–3.66)

3.85 (2.03–7.29)

2.38 (1.19–4.77)

2.39 (1.11–5.12)

≥ 232.60

7.18 (5.80–8.88)

2.98 (2.33–3.82)

2.46 (1.87–3.23)

12.87 (8.29–19.98)

5.89 (3.59–9.66)

3.93 (2.29–6.75)

7.96 (4.26–14.88)

4.09 (2.01–8.32)

3.67 (1.64–8.22)

P trend

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

ln(NT-proBNP), pg/ml

1.62 (1.56–1.69)

1.37 (1.30–1.44)

1.31 (1.23–1.39)

1.79 (1.67–1.91)

1.57 (1.43–1.71)

1.42 (1.28–1.59)

1.63 (1.45–1.83)

1.41 (1.22–1.63)

1.36 (1.15–1.63)

Creatinine, umol/L

< 66.72

1

1

1

1

1

1

1

1

1

66.72-< 79.56

1.35 (1.11–1.63)

0.97 (0.79–1.19)

0.99 (0.79–1.24)

1.59 (1.11–2.28)

0.96 (0.65–1.42)

1.01 (0.66–1.54)

1.74 (0.96–3.15)

1.83 (0.98–3.43)

1.87 (0.94–3.74)

79.56-< 97.24

1.90 (1.59–2.28)

1.14 (0.93–1.41)

1.18 (0.92–1.51)

2.29 (1.63–3.23)

1.06 (0.71–1.57)

1.03 (0.65–1.63)

2.54 (1.44–4.46)

2.79 (1.49–5.24)

3.00 (1.41–6.40)

≥ 97.24

3.45 (2.89–4.12)

1.55 (1.25–1.94)

1.47 (1.04–2.09)

3.69 (2.62–5.21)

1.31 (0.86-2.00)

1.05 (0.55–2.03)

5.27 (3.06–9.08)

4.59 (2.40–8.77)

5.16 (1.87–14.22)

P trend

< 0.001

< 0.001

0.038

< 0.001

0.132

0.870

< 0.001

< 0.001

0.001

ln(Creatinine), umol/L

2.76 (2.45–3.10)

1.95 (1.65–2.30)

1.76 (1.38–2.24)

2.83 (2.29–3.50)

1.90 (1.37–2.62)

1.49 (0.92–2.41)

3.59 (2.69–4.80)

3.40 (2.41–4.80)

3.43 (2.04–5.79)

Cystatin C, mg/L

< 0.72

1

1

1

1

1

1

1

1

1

0.72-< 0.85

2.33 (1.84–2.97)

1.62 (1.26–2.08)

1.68 (1.28–2.21)

2.23 (1.42–3.48)

1.43 (0.90–2.28)

1.56 (0.94–2.59)

2.32 (1.13–4.79)

2.20 (1.02–4.71)

1.90 (0.83–4.36)

0.85-< 1.05

3.65 (2.90–4.59)

1.81 (1.41–2.33)

1.92 (1.46–2.53)

3.48 (2.26–5.34)

1.47 (0.92–2.36)

1.68 (1.00-2.81)

3.22 (1.59–6.53)

2.55 (1.17–5.55)

2.61 (1.13-6.00)

≥ 1.05

8.45 (6.75–10.58)

3.36 (2.59–4.36)

3.54 (2.59–4.84)

9.02 (5.96–13.64)

3.25 (2.01–5.25)

3.26 (1.83–5.82)

11.82 (6.13–22.79)

8.15 (3.80-17.51)

10.06 (4.20-24.13)

P trend

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

ln(Cystatin C), mg/L

4.04 (3.59–4.55)

2.66 (2.26–3.14)

2.64 (2.11–3.31)

4.24 (3.43–5.25)

2.99 (2.22–4.02)

2.67 (1.74–4.08)

4.97 (3.65–6.77)

3.98 (2.72–5.82)

4.03 (2.33–6.97)

β-2 microglobulin, mg/L

< 1.86

1

1

1

1

1

1

1

1

1

1.86-< 2.23

2.09 (1.65–2.65)

1.36 (1.06–1.74)

1.45 (1.10–1.90)

1.85 (1.19–2.86)

1.17 (0.74–1.86)

1.41 (0.85–2.35)

2.94 (1.35–6.38)

2.73 (1.20–6.23)

2.53 (1.03–6.21)

2.23-< 2.92

3.69 (2.95–4.61)

1.97 (1.55–2.51)

2.13 (1.63–2.77)

3.39 (2.25–5.09)

1.72 (1.10–2.68)

2.20 (1.35–3.59)

4.65 (2.20–9.84)

3.90 (1.72–8.87)

3.98 (1.64–9.64)

≥ 2.92

7.75 (6.23–9.64)

3.18 (2.48–4.07)

3.63 (2.69–4.89)

7.65 (5.16–11.36)

3.09 (1.97–4.86)

3.42 (1.97–5.93)

14.01 (6.86–28.61)

9.68 (4.27–21.92)

12.84 (5.04–32.70)

P trend

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

ln(β-2 microglobulin), mg/L

3.37 (3.04–3.73)

2.40 (2.09–2.75)

2.43 (2.01–2.94)

3.33 (2.76–4.03)

2.51 (1.94–3.23)

2.14 (1.48–3.10)

4.12 (3.18–5.36)

3.33 (2.41–4.62)

3.60 (2.26–5.72)

Plasma glucose, mg/dL

< 124.70

1

1

1

1

1

1

1

1

1

124.70-< 144.30

0.93 (0.72–1.21)

0.94 (0.72–1.23)

0.99 (0.73–1.35)

0.98 (0.59–1.64)

1.01 (0.60–1.73)

1.33 (0.73–2.46)

0.67 (0.27–1.66)

0.65 (0.25–1.70)

0.63 (0.19–2.06)

144.30-< 188.00

1.13 (0.88–1.46)

1.15 (0.88–1.49)

1.18 (0.88–1.57)

1.57 (0.98–2.52)

1.60 (0.98–2.62)

1.93 (1.12–3.33)

1.64 (0.77–3.47)

1.93 (0.89–4.22)

1.66 (0.64–4.29)

≥ 188.00

1.24 (0.97–1.59)

1.56 (1.20–2.02)

1.67 (1.25–2.25)

1.86 (1.17–2.95)

2.45 (1.51–3.98)

3.33 (1.91–5.81)

1.63 (0.76–3.47)

2.12 (0.96–4.67)

2.54 (0.99–6.53)

P trend

0.033

< 0.001

< 0.001

0.001

< 0.001

< 0.001

0.056

0.009

0.011

ln(Plasma glucose), mmol/L

1.15 (0.91–1.46)

1.58 (1.21–2.05)

1.55 (1.15–2.08)

1.73 (1.15–2.60)

2.55 (1.61–4.05)

3.01 (1.80–5.03)

1.91 (0.97–3.75)

2.88 (1.37–6.07)

4.51 (1.84–11.08)

HbA1c, %

< 6.20

1

1

1

1

1

1

1

1

1

6.20-< 7.00

0.92 (0.78–1.09)

0.89 (0.75–1.06)

0.93 (0.76–1.12)

1.10 (0.81–1.50)

1.11 (0.80–1.54)

1.09 (0.76–1.57)

1.29 (0.73–2.29)

1.22 (0.67–2.21)

1.41 (0.72–2.78)

7.00-< 8.20

0.93 (0.78–1.11)

1.08 (0.90–1.30)

1.05 (0.86–1.28)

1.02 (0.74–1.41)

1.29 (0.91–1.81)

1.21 (0.83–1.77)

1.94 (1.12–3.34)

2.19 (1.25–3.85)

2.29 (1.19–4.40)

≥ 8.20

0.83 (0.69–0.99)

1.28 (1.06–1.55)

1.35 (1.10–1.67)

0.93 (0.67–1.29)

1.51 (1.05–2.16)

1.47 (0.98–2.20)

1.89 (1.10–3.24)

2.90 (1.65–5.12)

3.19 (1.65–6.19)

P trend

0.047

0.003

0.004

0.557

0.017

0.056

0.007

< 0.001

< 0.001

ln(HbA1c), %

0.73 (0.56–0.97)

1.79 (1.31–2.44)

1.97 (1.39–2.79)

0.93 (0.56–1.53)

2.52 (1.43–4.44)

2.49 (1.31–4.73)

2.55 (1.25–5.19)

6.55 (2.99–14.38)

8.50 (3.43–21.06)

Glycated albumin, %

< 15.09

1

1

1

1

1

1

1

1

1

15.09-< 17.54

1.27 (1.05–1.53)

0.94 (0.77–1.14)

0.91 (0.73–1.13)

1.41 (1.00-1.99)

0.97 (0.68–1.39)

0.95 (0.64–1.39)

3.78 (1.63–8.74)

3.56 (1.45–8.72)

2.78 (1.11–6.99)

17.54-< 22.10

1.34 (1.11–1.61)

1.13 (0.93–1.38)

1.06 (0.85–1.31)

1.29 (0.91–1.84)

1.03 (0.71–1.49)

0.85 (0.57–1.28)

5.98 (2.67–13.40)

6.44 (2.70-15.37)

4.97 (2.05–12.04)

≥ 22.10

1.28 (1.06–1.55)

1.41 (1.15–1.73)

1.43 (1.15–1.79)

1.38 (0.97–1.95)

1.50 (1.03–2.19)

1.44 (0.96–2.16)

6.67 (3.00-14.86)

8.76 (3.67–20.94)

6.36 (2.62–15.47)

P trend

0.008

< 0.001

0.001

0.130

0.038

0.173

< 0.001

< 0.001

< 0.001

ln(Glycated albumin), %

0.73 (0.56–0.97)

1.79 (1.31–2.44)

1.97 (1.39–2.79)

0.93 (0.56–1.53)

2.52 (1.43–4.44)

2.49 (1.31–4.73)

2.55 (1.25–5.19)

6.55 (2.99–14.38)

8.50 (3.43–21.06)