Table 2 Association of cumulative RC with CVD and subtypes in participants with hypertension
Quartiles of Cum-RC | Case/Total | Incidence density, per 1000 person-years | Model 1 | Model 2 | Model 3 |
|---|---|---|---|---|---|
Cardiovascular disease | |||||
 Q1 | 317/3587 | 8.77 | 1.00 | 1.00 | 1.00 |
 Q2 | 348/3587 | 9.65 | 1.15(0.99,1.34) | 1.08(0.93,1.26) | 1.07(0.92,1.26) |
 Q3 | 354/3588 | 9.86 | 1.19(1.02,1.39) | 1.09(0.94,1.28) | 1.08(0.91,1.28) |
 Q4 | 425/3587 | 11.87 | 1.43(1.24,1.65) | 1.29(1.10,1.50) | 1.26(1.03,1.54) |
 P-trend |  |  | < 0.0001 | 0.0015 | 0.0405 |
Myocardial infarction | |||||
 Q1 | 38/3587 | 1.02 | 1.00 | 1.00 | 1.00 |
 Q2 | 61/3587 | 1.64 | 1.71(1.14,2.56) | 1.57(1.05,2.37) | 1.51(1.00,2.31) |
 Q3 | 88/3588 | 2.38 | 2.52(1.72,3.70) | 2.30(1.56,3.39) | 2.02(1.22,3.27) |
 Q4 | 96/3587 | 2.58 | 2.74(1.88,3.99) | 2.48(1.68,3.66) | 2.08(1.41,3.28) |
 P-trend |  |  | < 0.0001 | < 0.0001 | < 0.0001 |
Ischemic Stroke | |||||
 Q1 | 248/3587 | 6.79 | 1.00 | 1.00 | 1.00 |
 Q2 | 253/3587 | 6.93 | 1.07(0.90,1.28) | 1.00(0.84,1.20) | 1.02(0.84,1.24) |
 Q3 | 258/3588 | 7.04 | 1.08(0.91,1.29) | 1.02(0.86,1.22) | 1.04(0.86,1.25) |
 Q4 | 296/3587 | 8.61 | 1.33(1.13,1.58) | 1.23(1.04,1.47) | 1.29(1.02,1.62) |
 P-trend |  |  | 0.0012 | 0.0249 | 0.0336 |
Hemorrhagic stroke | |||||
 Q1 | 40/3587 | 1.02 | 1.00 | 1.00 | 1.00 |
 Q2 | 40/3587 | 1.02 | 1.03(0.66,1.59) | 1.04(0.67,1.62) | 1.06(0.68,1.71) |
 Q3 | 32/3588 | 0.81 | 0.82(0.52,1.31) | 0.79(0.49,1.28) | 0.86(0.50,1.46) |
 Q4 | 36/3587 | 0.91 | 0.92(0.59,1.45) | 0.83(0.52,1.34) | 0.97(0.51,1.84) |
 P-trend |  |  | 0.5254 | 0.2886 | 0.7247 |