Association between the insulin resistance and all-cause mortality in patients with moderate and severe aortic stenosis: a retrospective cohort study

Table 3 Association between the TyG index and all-cause mortality in the moderate to severe AS patients*

	Events/Total	Model 1		Model 2		Model 3
	Events/Total	HR (95%CI)	p value	HR (95%CI)	p value	HR (95%CI)	p value
Continuous (per unit)	84/317 (26.5)	1.279 (0.887, 1.821)	0.184	1.654 (1.119, 2.431)	0.012	1.622 (1.086, 2.416)	0.018
Lower TyG index	37/168 (22.0)	Reference	–	Reference	–	Reference	–
Higher TyG index	47/149 (31.5)	1.493 (0.970, 2.311)	0.067	1.802 (1.136, 2.867)	0.012	1.746 (1.093, 2.798)	0.019

*Cox regressions with Firth’s penalized maximum likelihood method were used
Model 1 Adjusted by sex, age
Model 2 Adjusted by model 1 + body mass index, low-density lipoprotein cholesterol, systolic blood pressure, diastolic blood pressure, smoking status, drinking status, aortic stenosis severity, pulmonary arterial hypertension, LV ejection fraction, bicuspid aortic valve, and aortic valve replacement
Model 3 Adjusted by model 2 + diabetes mellitus, CHD, antiplatelets, and statins use
TyG, triglyceride-glucose; HR, hazard ratio; CI, confidence interval

ISSN: 1475-2840