Table 3 Mediation MR analysis outcomes
Mediators | Outcomes | Mediation effect in total effect | 95%CI |
|---|---|---|---|
Hypertension | PAS | 11.47% | 3.23–19.71% |
CAS | 16.84% | 5.35–28.33% | |
BMI | PAS | -1.71% | -6.78–3.37% |
CAS | -3.33% | -8.20–1.53% | |
Smoking current | PAS | 1.67% | -4.77–8.10% |
CAS | 0.38% | -3.51–4.27% | |
Smoking previous | PAS | -0.10% | -4.50–4.30% |
CAS | 0.02% | -2.62–2.66% | |
IL-6 | PAS | -2.76% | -17.56–12.03% |
CAS | -2.47% | -15.02–10.09% | |
CRP | PAS | 1.22% | -1.28–3.72% |
CAS | 1.32% | -2.41–5.05% | |
apo A | PAS | 0.58% | -0.94–2.10% |
CAS | 0.75% | -1.22–2.71% | |
apo B | PAS | 0.85% | -3.10–4.81% |
CAS | 1.82% | -6.57–10.21% | |
Lipoprotein A | PAS | 0.27% | -0.94–1.47% |
CAS | 0.36% | -1.17–1.88% | |
Total cholesterol | PAS | -2.68% | -8.02–2.66% |
CAS | -7.33% | -20.91–6.24% | |
Triglycerides | PAS | -5.11% | -12.17–1.95% |
CAS | -10.02% | -23.05–3.02% | |
HDL | PAS | -3.69% | -7.97–0.58% |
CAS | -4.06% | -8.94–0.81% | |
LDL | PAS | -7.90% | -15.99–0.19% |
CAS | -20.33 | -39.56%– -1.09% |