Variables | Overall | Q1 | Q2 | Q3 | Q4 | P value |
---|---|---|---|---|---|---|
Number of patients | 1393 | 349 | 348 | 348 | 348 | Â |
Male,n(%) | 822 (59.0) | 208 (59.6) | 204 (58.6) | 211 (60.6) | 199 (57.2) | 0.818 |
Age,years,(median [IQR]) | 71.00 [60.00, 81.00] | 75.00 [63.00, 84.00] | 73.50 [61.75, 82.00] | 70.00 [59.75, 80.00] | 66.00 [57.00, 75.00] | < 0.001 |
Race,n(%) | Â | Â | Â | Â | Â | 0.069 |
White | 915 (65.7) | 222 (63.6) | 230 (66.1) | 232 (66.7) | 231 (66.4) | Â |
Black | 97 (7.0) | 38 (10.9) | 22 (6.3) | 20 (5.7) | 17 (4.9) | Â |
Asian | 32 (2.3) | 11 (3.2) | 9 (2.6) | 4 (1.1) | 8 (2.3) | Â |
Others | 349 (25.1) | 78 (22.3) | 87 (25.0) | 92 (26.4) | 92 (26.4) | Â |
BMI,kg/m2,n(%) | Â | Â | Â | Â | Â | 0.001 |
 <30 | 415 (29.8) | 117 (33.5) | 114 (32.8) | 97 (27.9) | 87 (25.0) |  |
 >=30 | 244 (17.5) | 47 (13.5) | 57 (16.4) | 54 (15.5) | 86 (24.7) |  |
 Missing | 734 (52.7) | 185 (53.0) | 177 (50.9) | 197 (56.6) | 175 (50.3) |  |
ASPIII (median [IQR]) | 43.00 [32.00, 55.00] | 41.00 [31.00, 52.00] | 42.00 [32.00, 54.25] | 43.00 [33.00, 55.00] | 49.00 [35.00, 62.00] | < 0.001 |
SAPIII (median [IQR]) | 36.00 [29.00, 45.00] | 35.00 [28.00, 43.00] | 35.00 [30.00, 44.00] | 37.00 [29.00, 46.00] | 37.50 [29.00, 47.00] | 0.11 |
SIRS score (median [IQR]) | 3.00 [2.00, 3.00] | 2.00 [2.00, 3.00] | 2.00 [2.00, 3.00] | 3.00 [2.00, 3.00] | 3.00 [2.00, 3.00] | < 0.001 |
SOFA score (median [IQR]) | 4.00 [2.00, 7.00] | 4.00 [2.00, 7.00] | 4.00 [2.00, 7.00] | 4.00 [2.00, 7.00] | 5.00 [3.00, 8.00] | < 0.001 |
Vital Signs | Â | Â | Â | Â | Â | Â |
HR (median [IQR]) | 87.00 [75.00, 101.00] | 85.00 [75.00, 100.00] | 87.00 [75.00, 102.25] | 87.00 [75.00, 99.00] | 88.00 [78.00, 103.00] | 0.183 |
SBP,mmhg,n(%) | Â | Â | Â | Â | Â | 0.268 |
 < 90 | 13 (0.9) | 4 (1.1) | 3 (0.9) | 4 (1.1) | 2 (0.6) |  |
 >140 | 158 (11.3) | 37 (10.6) | 32 (9.2) | 37 (10.6) | 52 (14.9) |  |
 90–140 | 496 (35.6) | 124 (35.5) | 124 (35.6) | 115 (33.0) | 133 (38.2) |  |
 Missing | 726 (52.1) | 184 (52.7) | 189 (54.3) | 192 (55.2) | 161 (46.3) |  |
DBP,mmhg,n(%) | Â | Â | Â | Â | Â | 0.367 |
 < 60 | 94 (6.7) | 28 (8.0) | 24 (6.9) | 19 (5.5) | 23 (6.6) |  |
 > 90 | 53 (3.8) | 13 (3.7) | 11 (3.2) | 15 (4.3) | 14 (4.0) |  |
 60–90 | 520 (37.3) | 124 (35.5) | 124 (35.6) | 122 (35.1) | 150 (43.1) |  |
 Missing | 726 (52.1) | 184 (52.7) | 189 (54.3) | 192 (55.2) | 161 (46.3) |  |
Laboratory tests | Â | Â | Â | Â | Â | Â |
Lymphocyte,%,n(%) |  |  |  |  |  | < 0.001 |
 <7 | 281 (20.2) | 49 (14.0) | 74 (21.3) | 76 (21.8) | 82 (23.6) |  |
 > 18.8 | 202 (14.5) | 51 (14.6) | 42 (12.1) | 49 (14.1) | 60 (17.2) |  |
 11.50–18.80 | 253 (18.2) | 74 (21.2) | 63 (18.1) | 65 (18.7) | 51 (14.7) |  |
 7–11.50 | 274 (19.7) | 54 (15.5) | 59 (17.0) | 72 (20.7) | 89 (25.6) |  |
 Missing | 383 (27.5) | 121 (34.7) | 110 (31.6) | 86 (24.7) | 66 (19.0) |  |
Neutrophils,%,n(%) |  |  |  |  |  | < 0.001 |
 <69.8 | 211 (15.1) | 58 (16.6) | 50 (14.4) | 46 (13.2) | 57 (16.4) |  |
 > 85.9 | 277 (19.9) | 53 (15.2) | 67 (19.3) | 76 (21.8) | 81 (23.3) |  |
 69.8–79.60 | 251 (18.0) | 68 (19.5) | 55 (15.8) | 71 (20.4) | 57 (16.4) |  |
 79.60–85.90 | 271 (19.5) | 49 (14.0) | 66 (19.0) | 69 (19.8) | 87 (25.0) |  |
 Missing | 383 (27.5) | 121 (34.7) | 110 (31.6) | 86 (24.7) | 66 (19.0) |  |
Platelets,(K/uL),(median [IQR]) | 209.00 [161.00, 268.00] | 198.00 [151.00, 254.00] | 208.00 [165.00, 262.00] | 212.00 [164.00, 273.50] | 214.50 [165.75, 282.00] | 0.03 |
WBC (median [IQR]) | 10.30 [7.60, 13.80] | 8.40 [6.70, 11.40] | 9.80 [7.70, 12.65] | 11.60 [8.15, 14.60] | 11.75 [8.60, 16.50] | < 0.001 |
RBC,m/uL,(median [IQR]) | 3.92 [3.41, 4.43] | 3.91 [3.47, 4.40] | 3.95 [3.41, 4.41] | 3.96 [3.42, 4.44] | 3.86 [3.35, 4.44] | 0.825 |
Hemoglobin,g/dL,(median [IQR]) | 11.70 [10.10, 13.20] | 11.70 [10.40, 13.20] | 11.70 [10.10, 13.28] | 11.80 [10.25, 13.25] | 11.30 [9.80, 13.20] | 0.312 |
PCO2,mmhg,(median [IQR]) | 41.00 [35.00, 48.00] | 40.00 [34.00, 46.00] | 40.00 [34.00, 48.00] | 41.00 [35.50, 49.00] | 41.00 [36.00, 49.00] | 0.029 |
PH (median [IQR]) | 7.39 [7.33, 7.44] | 7.41 [7.35, 7.44] | 7.40 [7.36, 7.45] | 7.39 [7.33, 7.44] | 7.37 [7.30, 7.42] | < 0.001 |
PO2,mmhg,(median [IQR]) | 99.00 [63.25, 190.75] | 102.00 [66.00, 241.00] | 98.50 [67.00, 199.75] | 89.00 [56.00, 161.50] | 104.50 [65.75, 187.25] | 0.073 |
Albumin,g/dL(median [IQR]) | 3.30 [2.80, 3.70] | 3.50 [3.00, 3.80] | 3.40 [2.90, 3.70] | 3.20 [2.80, 3.70] | 3.20 [2.70, 3.60] | < 0.001 |
BUN,mg/dL(median [IQR]) | 22.00 [16.00, 35.00] | 21.00 [16.00, 31.00] | 21.00 [16.00, 34.25] | 23.00 [17.00, 37.00] | 23.00 [16.00, 40.00] | 0.022 |
SCR, mg/dL,(median [IQR]) | 1.10 [0.80, 1.50] | 1.00 [0.80, 1.40] | 1.00 [0.80, 1.40] | 1.10 [0.90, 1.63] | 1.10 [0.90, 1.80] | 0.001 |
UCR,mg/dL,n(%) | Â | Â | Â | Â | Â | 0.058 |
 < 48 | 134 (9.6) | 35 (10.0) | 29 (8.3) | 28 (8.0) | 42 (12.1) |  |
 > 122 | 135 (9.7) | 30 (8.6) | 30 (8.6) | 42 (12.1) | 33 (9.5) |  |
 48–78 | 127 (9.1) | 33 (9.5) | 24 (6.9) | 38 (10.9) | 32 (9.2) |  |
 78–122 | 132 (9.5) | 22 (6.3) | 33 (9.5) | 43 (12.4) | 34 (9.8) |  |
 Missing | 865 (62.1) | 229 (65.6) | 232 (66.7) | 197 (56.6) | 207 (59.5) |  |
HDL,mg/dL,n(%) |  |  |  |  |  | < 0.001 |
 < 33 | 248 (17.8) | 40 (11.5) | 67 (19.3) | 71 (20.4) | 70 (20.1) |  |
 > 53 | 238 (17.1) | 98 (28.1) | 71 (20.4) | 40 (11.5) | 29 (8.3) |  |
 33–42 | 272 (19.5) | 64 (18.3) | 74 (21.3) | 72 (20.7) | 62 (17.8) |  |
 42–53 | 258 (18.5) | 87 (24.9) | 61 (17.5) | 61 (17.5) | 49 (14.1) |  |
 Missing | 377 (27.1) | 60 (17.2) | 75 (21.6) | 104 (29.9) | 138 (39.7) |  |
LDL,mg/dL,n(%) |  |  |  |  |  | < 0.001 |
 < 55 | 249 (17.9) | 80 (22.9) | 65 (18.7) | 55 (15.8) | 49 (14.1) |  |
 > 103 | 245 (17.6) | 52 (14.9) | 58 (16.7) | 74 (21.3) | 61 (17.5) |  |
 55–76 | 255 (18.3) | 85 (24.4) | 67 (19.3) | 62 (17.8) | 41 (11.8) |  |
 76–103 | 250 (17.9) | 71 (20.3) | 82 (23.6) | 53 (15.2) | 44 (12.6) |  |
 Missing | 394 (28.3) | 61 (17.5) | 76 (21.8) | 104 (29.9) | 153 (44.0) |  |
TG,mg/dL,(median [IQR]) | 113.00 [84.00, 164.00] | 70.00 [57.00, 85.00] | 104.00 [86.00, 119.25] | 138.00 [108.00, 168.25] | 209.50 [154.00, 290.25] | < 0.001 |
TC,mg/dL,n(%) |  |  |  |  |  | < 0.001 |
 <116 | 257 (18.4) | 89 (25.5) | 70 (20.1) | 56 (16.1) | 42 (12.1) |  |
 >174 | 259 (18.6) | 51 (14.6) | 59 (17.0) | 68 (19.5) | 81 (23.3) |  |
 116–145 | 275 (19.7) | 92 (26.4) | 77 (22.1) | 59 (17.0) | 47 (13.5) |  |
 145–174 | 253 (18.2) | 60 (17.2) | 72 (20.7) | 70 (20.1) | 51 (14.7) |  |
 Missing | 349 (25.1) | 57 (16.3) | 70 (20.1) | 95 (27.3) | 127 (36.5) |  |
Glucose,mg/dL,(median [IQR]) | 129.00 [106.00, 172.00] | 104.00 [92.00, 120.00] | 121.50 [104.00, 143.00] | 141.50 [114.00, 173.00] | 202.00 [147.00, 263.25] | < 0.001 |
HbA1c%,n(%) |  |  |  |  |  | < 0.001 |
 < 5.7 | 275 (19.7) | 98 (28.1) | 86 (24.7) | 61 (17.5) | 30 (8.6) |  |
 > 6.4 | 261 (18.7) | 27 (7.7) | 53 (15.2) | 62 (17.8) | 119 (34.2) |  |
 5.7–6.4 | 287 (20.6) | 93 (26.6) | 78 (22.4) | 67 (19.3) | 49 (14.1) |  |
 Missing | 570 (40.9) | 131 (37.5) | 131 (37.6) | 158 (45.4) | 150 (43.1) |  |
TNTµg/L,n(%) |  |  |  |  |  | 0.001 |
 <0.06 | 202 (14.5) | 60 (17.2) | 51 (14.7) | 49 (14.1) | 42 (12.1) |  |
 >0.975 | 203 (14.6) | 34 (9.7) | 45 (12.9) | 54 (15.5) | 70 (20.1) |  |
 0.06–0.25 | 208 (14.9) | 45 (12.9) | 55 (15.8) | 52 (14.9) | 56 (16.1) |  |
 0.25–0.975 | 198 (14.2) | 36 (10.3) | 61 (17.5) | 56 (16.1) | 45 (12.9) |  |
 Missing | 582 (41.8) | 174 (49.9) | 136 (39.1) | 137 (39.4) | 135 (38.8) |  |
CKMB(IU/L),n(%) | Â | Â | Â | Â | Â | 0.299 |
 < 3 | 180 (12.9) | 49 (14.0) | 46 (13.2) | 45 (12.9) | 40 (11.5) |  |
 > 18 | 280 (20.1) | 66 (18.9) | 55 (15.8) | 84 (24.1) | 75 (21.6) |  |
 3–6 | 2 (0.1) | 0 (0.0) | 1 (0.3) | 0 (0.0) | 1 (0.3) |  |
 6–18 | 13 (0.9) | 2 (0.6) | 6 (1.7) | 2 (0.6) | 3 (0.9) |  |
 Missing | 918 (65.9) | 232 (66.5) | 240 (69.0) | 217 (62.4) | 229 (65.8) |  |
NT-proBNP,pg/mL,n(%) | Â | Â | Â | Â | Â | 0.27 |
 <1632 | 78 (5.6) | 21 (6.0) | 16 (4.6) | 14 (4.0) | 27 (7.8) |  |
 >10,521 | 78 (5.6) | 20 (5.7) | 17 (4.9) | 23 (6.6) | 18 (5.2) |  |
 1632–3955 | 78 (5.6) | 14 (4.0) | 20 (5.7) | 21 (6.0) | 23 (6.6) |  |
 3955–10521 | 77 (5.5) | 13 (3.7) | 26 (7.5) | 22 (6.3) | 16 (4.6) |  |
 Missing | 1082 (77.7) | 281 (80.5) | 269 (77.3) | 268 (77.0) | 264 (75.9) |  |
CRP(mg/L),n(%) | Â | Â | Â | Â | Â | 0.295 |
 < 13.95 | 41 (2.9) | 15 (4.3) | 13 (3.7) | 8 (2.3) | 5 (1.4) |  |
 >134.4 | 41 (2.9) | 7 (2.0) | 9 (2.6) | 12 (3.4) | 13 (3.7) |  |
 13.95–57.90 | 41 (2.9) | 9 (2.6) | 10 (2.9) | 14 (4.0) | 8 (2.3) |  |
 57.90-134.4 | 40 (2.9) | 6 (1.7) | 14 (4.0) | 11 (3.2) | 9 (2.6) |  |
 Missing | 1230 (88.3) | 312 (89.4) | 302 (86.8) | 303 (87.1) | 313 (89.9) |  |
Potassium,mmol/L,(median [IQR]) | 4.10 [3.80, 4.50] | 4.10 [3.70, 4.50] | 4.10 [3.80, 4.50] | 4.10 [3.80, 4.50] | 4.20 [3.80, 4.70] | 0.03 |
Sodium,mmol/L,(median [IQR]) | 139.00 [136.00, 141.00] | 140.00 [136.00, 142.00] | 139.00 [136.00, 142.00] | 139.00 [136.00, 141.00] | 138.00 [135.00, 141.00] | < 0.001 |
TyG index,(median [IQR]) | 4.82 [4.61, 5.07] | 4.47 [4.37, 4.55] | 4.71 [4.67, 4.78] | 4.94 [4.88, 5.00] | 5.28 [5.17, 5.48] | < 0.001 |
Comorbidities,n (%) | Â | Â | Â | Â | Â | Â |
AF,n(%) | 613 (44.0) | 185 (53.0) | 165 (47.4) | 132 (37.9) | 131 (37.6) | < 0.001 |
AMI,n(%) | 485 (34.8) | 82 (23.5) | 122 (35.1) | 137 (39.4) | 144 (41.4) | < 0.001 |
CKD,n(%) | 383 (27.5) | 96 (27.5) | 89 (25.6) | 96 (27.6) | 102 (29.3) | 0.748 |
COPD,n(%) | 164 (11.8) | 41 (11.7) | 47 (13.5) | 47 (13.5) | 29 (8.3) | 0.113 |
Dyslipidemia,n(%) | 658 (47.2) | 156 (44.7) | 168 (48.3) | 159 (45.7) | 175 (50.3) | 0.443 |
Diabetes,n(%) | 524 (37.6) | 65 (18.6) | 105 (30.2) | 135 (38.8) | 219 (62.9) | < 0.001 |
Hypertension,n(%) | 494 (35.5) | 130 (37.2) | 121 (34.8) | 123 (35.3) | 120 (34.5) | 0.871 |
PCI,n(%) | 189 (13.6) | 29 (8.3) | 45 (12.9) | 55 (15.8) | 60 (17.2) | 0.003 |
CABG,n(%) | 69 (5.0) | 14 (4.0) | 11 (3.2) | 17 (4.9) | 27 (7.8) | 0.031 |
Medications | Â | Â | Â | Â | Â | Â |
ARNI,n(%) | 11 (0.8) | 2 (0.6) | 4 (1.1) | 3 (0.9) | 2 (0.6) | 0.798 |
ACEI,n(%) | 634 (45.5) | 164 (47.0) | 164 (47.1) | 172 (49.4) | 134 (38.5) | 0.021 |
ARB,n(%) | 135 (9.7) | 25 (7.2) | 40 (11.5) | 38 (10.9) | 32 (9.2) | 0.209 |
Beta blocker,n(%) | 1090 (78.2) | 267 (76.5) | 276 (79.3) | 287 (82.5) | 260 (74.7) | 0.07 |
Digoxin, n(%) | 165 (11.8) | 48 (13.8) | 53 (15.2) | 34 (9.8) | 30 (8.6) | 0.019 |
Loop diuretics,n(%),n(%) | 1129 (81.0) | 277 (79.4) | 284 (81.6) | 282 (81.0) | 286 (82.2) | 0.8 |
Events | Â | Â | Â | Â | Â | Â |
AKIb,n(%) | 1154 (82.8) | 277 (79.4) | 287 (82.5) | 294 (84.5) | 296 (85.1) | 0.183 |