Sex-specific associations between adipokine profiles and carotid-intima media thickness in the Cameron County Hispanic Cohort (CCHC)

Table 2 Estimated association between adipokines and cIMT (continuous) in CCHC study participants

	Model 1*			Model 2 *			Model 3*			Model 4*			Model 5*
	Beta	SE	p	Beta	SE	p	Beta	SE	p	Beta	SE	p	Beta	SE	p
Both sexes-combined
Adiponectin^a	0.004	0.005	0.472	0.005	0.005	0.358	0.002	0.005	0.716	0.003	0.005	0.520	0.005	0.005	0.350
Leptin^a	0.004	0.005	0.427	0.003	0.007	0.680	− 0.001	0.007	0.860	0.001	0.007	0.930	0.003	0.007	0.655
Resistin	0.003	0.005	0.568	0.002	0.005	0.634	0.000	0.005	0.954	− 0.001	0.005	0.839	− 0.001	0.005	0.810
LAR^a	0.004	0.005	0.423	0.003	0.006	0.642	0.002	0.006	0.713	0.002	0.006	0.723	0.002	0.006	0.730
ARI	− 0.001	0.005	0.867	− 0.002	0.005	0.658	− 0.002	0.005	0.700	− 0.004	0.005	0.415	− 0.006	0.005	0.243
Female
Adiponectin	0.008	0.005	0.074	0.009	0.005	0.060	0.007	0.005	0.170	0.008	0.005	0.076	0.010	0.005	0.043
Leptin	− 0.002	0.005	0.741	− 0.003	0.006	0.634	− 0.007	0.006	0.291	− 0.005	0.006	0.436	− 0.003	0.006	0.588
Resistin	0.006	0.005	0.263	0.005	0.005	0.330	0.002	0.005	0.631	0.002	0.005	0.713	0.002	0.005	0.754
LAR	− 0.006	0.005	0.184	− 0.008	0.005	0.130	− 0.009	0.005	0.089	− 0.009	0.005	0.075	− 0.009	0.005	0.069
ARI	− 0.005	0.005	0.351	− 0.006	0.005	0.270	− 0.006	0.005	0.244	− 0.009	0.005	0.083	− 0.011	0.005	0.036
Male
Adiponectin	− 0.016	0.013	0.240	− 0.015	0.013	0.244	− 0.020	0.014	0.146	− 0.020	0.014	0.154	− 0.020	0.014	0.148
Leptin	0.043	0.016	0.011	0.041	0.020	0.048	0.036	0.021	0.087	0.038	0.021	0.070	0.038	0.021	0.064
Resistin	− 0.001	0.011	0.898	− 0.002	0.011	0.859	− 0.006	0.011	0.575	− 0.007	0.011	0.546	− 0.007	0.011	0.521
LAR	0.060	0.014	4.41E−05	0.062	0.016	1.39E−04	0.061	0.016	2.12E−04	0.062	0.016	1.90E−04	0.060	0.016	2.52E−04
ARI	0.010	0.011	0.397	0.009	0.011	0.441	0.010	0.011	0.396	0.009	0.012	0.451	0.008	0.012	0.477

^*Linear mixed effect model was applied. A kinship matrix estimated based on genotype information among samples was included as a random effect. Fixed effect covariates were age, sex in model 1; age, sex, BMI, and ever smoking in model 2; age, sex, BMI, ever smoking, and cytokines (IL-6, IL-8, TNF-a, IL-1b) in model 3; age, sex, BMI, ever smoking, cytokines, and metabolic health (glucose tolerance, BP, and lipid profile) in model 4; age, sex, BMI, ever-smoking, cytokines, metabolic health, and medication usage for T2D, hypertension, or lipid-lowering in model 5. (Sex was included only in the sexes-combined models)
Beta coefficients indicate the increase in cIMT levels by every 1-SD unit increase of adipokines
^aSignificant interaction by sex (p for interaction < 0.1) from Model 5

ISSN: 1475-2840