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Table 1 Participant Characteristics and Clinical Laboratory Values

From: Endogenous estradiol contributes to vascular endothelial dysfunction in premenopausal women with type 1 diabetes

Variable

Type 1 Diabetes

Controls

p-value

(n = 32)

(n = 25)

Demographics

   

Age (y)

25 ± 6

24 ± 6

0.365

 Time Since Diagnosis (y)

13 ± 7

  

Height (cm)

163.5 ± 7.0

165.4 ± 5.8

0.273

Weight (kg)

72.8 ± 17.6

68.4 ± 15.8

0.336

BMI (kg/m2)

27.2 ± 5.7

24.5 ± 4.7

0.060

MAP (mm Hg)

87 ± 8

83 ± 7

0.069

Clinical Laboratory Values

CRP (mg/L)

5.4 ± 8.3

1.2 ± 1.3

0.008

TC (mg/dL)

178 ± 41

163 ± 35

0.161

HDL (mg/dL)

58 ± 17

53 ± 13

0.228

LDL (mg/dL)

98 ± 42

88 ± 39

0.337

TRIG (mg/dL)

76 ± 45

63 ± 28

0.158

TC/HDL ratio

3.2 ± 1.1

3.2 ± 0.8

0.788

HbA1c (%)

8.6 ± 1.7

5.2 ± 0.3

< 0.001

FBG (mg/dL) – Menses

153 ± 79

85 ± 9

< 0.001

FBG (mg/dL) – Late Follicular

168 ± 95

85 ± 10

< 0.001

Insulin (uIU/mL) – Menses

3.1 ± 9.8

8.1 ± 4.6

0.015

Insulin (uIU/mL) – Late Follicular

2.9 ± 7.8

9.4 ± 5.8

< 0.001

Estradiol (pg/mL) – Menses

40 ± 25 (9-114)

30 ± 15 (8–72)

0.084

Estradiol (pg/mL) – Late Follicular

115 ± 82* (25–356)

100 ± 84* (17–391)

0.521

LH (mIU/mL) – Menses

6 ± 4 (1–21)

7 ± 2 (3–14)

0.783

LH (mIU/mL) – Late Follicular

12 ± 7* (3–36)

16 ± 13* (7–56)

0.099

Progesterone (ng/mL) – Menses

0.4 ± 0.4 (0.1–1.5)

0.3 ± 0.2 (0.1–0.8)

0.469

Progesterone (ng/mL) – Late Follicular

0.9 ± 1.5 (0.1-7.0)

1.0 ± 1.6* (0.1–6.3)

0.799

  1. Data are presented as mean ± SD (Range); independent samples t test. Bold values indicate statistically significant differences between groups. *Significant difference from Menses within group. BMI = Body Mass Index, MAP = Mean Arterial Pressure, CRP = C-Reactive Protein, TC = Total Cholesterol, HDL = High-Density Lipoprotein, LDL = Low-Density Lipoprotein, TRIG = Triglycerides, HbA1c = Hemoglobin A1c, FBG = Fasting Blood Glucose, LH = Luteinizing Hormone