Fig. 3
From: The role of oxidative stress in diabetes mellitus-induced vascular endothelial dysfunction
The role of microRNAs and histone acetylation in ROS-induced endothelial dysfunction in diabetic vascular complications. In the diabetic state, oxidative stress induced by epigenetic alterations such as microRNAs and histone acetylation alterations leads to endothelial physiological dysfunction. Abbreviations: ROS, reactive oxygen species; JNK, Jun NH2-terminal kinase; SIRT1, Sirtuin1; Keap, kelch-like ECH-associated protein; Nrf2, Nuclear factor erythroid 2-related factor 2; Pin1, peptidyl-prolyl cis/trans isomerase 1; EGR1, Early Growth Response Protein 1; HO-1, heme oxygenase‐1; HMGB1, high-mobility group box 1; MFN2, mitofusin 2; TLR4, toll-like receptor 4; NF-κB, nuclear factor-κB; HMGB1, high-mobility group box 1;HDAC, histone deacetylase; MnSOD, manganese superoxide dismutase; H3K9, histone 3 lysine 9; UHRF1, ubiquitin-like containing PHD and RING finger domains 1