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Fig. 8 | Cardiovascular Diabetology

Fig. 8

From: The tyrosine kinase inhibitor Dasatinib reduces cardiac steatosis and fibrosis in obese, type 2 diabetic mice

Fig. 8

Effect of Dasatinib on the expression of adipogenesis-related gene transcripts and proteins in human cells. (A-C) Results of qPCR showing a general tendency of Dasatinib-treated cells to have increased mRNA transcripts during induced adipogenesis. (D-G) Protein level for FABP4, but not for ADIPOQ or PPARɣ, is upregulated with Dasatinib. In (G), after normalisation versus GAPDH, PPARɣ levels were expressed as a fold-change versus untreated baseline cells. Bar graphs show means ± SEM and individual values. n = 4 per group

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Cardiovascular Diabetology

ISSN: 1475-2840