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Fig. 3 | Cardiovascular Diabetology

Fig. 3

From: The tyrosine kinase inhibitor Dasatinib reduces cardiac steatosis and fibrosis in obese, type 2 diabetic mice

Fig. 3

Prolonged Dasatinib treatment reduces lipid content in the heart and bone marrow, and interstitial fibrosis in the heart, of db/db mice. Representative images and bar graphs showing the effect of diabetes and Dasatinib on lipid accumulation in the heart (A & B) and bone marrow (C & D). Correlation between lipid content in the heart and bone marrow (E) and lipid content in the heart and E/A ratio (F). Effect of diabetes and Dasatinib on other fat depots (G-I). Representative Azan Mallory images (blue: fibrosis) and bar graph showing the effect of diabetes and Dasatinib on myocardial interstitial fibrosis (J & K). Bar graphs show individual values and means ± SEM. n = 6 to 8 animals per group

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Cardiovascular Diabetology

ISSN: 1475-2840