Fig. 2

Adjusted analysis for the effect of semaglutide on MACE risk by baseline eGFR and UACR. *Cut-off point for ARR was 1 year for eGFR and 2 years for UACR. ^†Data previously published in Husain [18] (N numbers for total randomised participants, regardless of available baseline eGFR or UACR values, were 6,480 [total] and 3,297 [SUSTAIN 6]). ^‡Participants with eGFR < 30 mL/min/1.73 m² from SUSTAIN 6 were included for the analysis in the eGFR < 45 mL/min/1.73 m² as well as UACR < 30, ≥30–≤300, and > 300 mg/g subgroups with the following numbers (%): 139 (19.0); 22 (1.1); 20 (2.3); 68 (16.2). ^§SUSTAIN 6 data only; UACR was not measured in PIONEER 6. A Cox proportional hazards model was adjusted with inverse probability weighting, using baseline predictors of cardiorenal disease and continuous eGFR or UACR values at baseline. %, proportion of participants with ≥ 1 cardiovascular event; ARR, absolute risk reduction; CI, confidence interval; eGFR, estimated glomerular filtration rate; HR, hazard ratio; MACE, major adverse cardiovascular event; N, total number of participants in pooled population or subgroup with eGFR or UACR values at baseline; n, number of participants with ≥ 1 cardiovascular event; p_INT, interaction p value; UACR, urine albumin:creatinine ratio