Fig. 8

Cardiac endothelial-specific overexpression of MICU1 alleviates diabetes-induced cardiac dysfunction in diabetic mice. (A) The heart weight of different groups. (B) The ratios of heart weight to tibia length (HW/TL) for different groups. (C) Representative echocardiographic images of the LV in different mice (aged 18 weeks). (D, E, F and G) Echocardiographic assessment of heart rate (D), Echocardiographic assessment of LV fractional shortening (LVFS; E), LV end diastolic diameter (LVIDd; F) and LV diastolic posterior wall thickness (LVPWd; G) in different mice (n = 6, 18-week-old per group). (H) Cardiomyocyte cross-sectional area was analyzed using hematoxylin and eosin staining and wheat germ agglutinin staining in hearts from different mice (n = 6, 18-week-old per group); scale bar = 20 μm. (I) Comparative quantitative analysis of cardiomyocyte CSA. (J) Representative images and comparative quantitative analysis of Masson trichrome staining of hearts from different mice (n = 6 per group); scale bar = 20 μm. *p < 0.05, **p < 0.01