Plasma metabolite profiles associated with the World Cancer Research Fund/American Institute for Cancer Research lifestyle score and future risk of cardiovascular disease and type 2 diabetes

Table 2 Performance of the HL predicted values using the metabolite profile identified and the HL score as the categorical or continuous variable at baseline (discovery) and at 1 year of follow-up (validation)

	Baseline visit (n = 1833)				1-year visit (n = 1524)
Assessment	AUC or correlation coefficient (95% CI)	Total metabolites^c	Metabolites with positive coefficients	Metabolites with negative coefficients	AUC or correlation coefficient (95% CI)
HL categories	0.73 (0.70, 0.75)^a	24	13	11	0.68 (0.65, 0.71) ^a
HL score	0.50 (0.47, 0.54) ^b	58	25	33	0.44 (0.40, 0.48) ^b

^aAUC of the ROC derived from the HL predicted values using the metabolite profile
^bThe Pearson’s coefficients derived from the correlation between the HL score and the predicted values using the metabolite signature within the discovery and validation dataset
^cNumber of metabolites obtained after the ten iterations of the 10-fold cross-validation procedure for the elastic net regression
AUC, area under the curve; ROC, receiver operating characteristic; HL, Healthy Lifestyle

ISSN: 1475-2840