Variables | Visit | Continuous care intervention (n = 194) | Usual care (n = 68) | Between group effect | |||
---|---|---|---|---|---|---|---|
Mean ± SE | Change from baseline (Mean, CI) | Mean ± SE | Change from baseline (Mean, CI) | Mean difference | 95% CI | ||
Total VLDL (nmol/L) | Baseline | 138.6 ± 5.7 | 144.0 ± 8.4 | − 5.3 | − 25.4 to 14.8 | ||
1 year | 128.7 ± 5.8 | − 9.9, − 25.8 to 5.9 | 146.9 ± 8.7 | 3.0, − 20.3 to 26.2 | − 18.2 | − 39.0 to 2.5 | |
2 years | 129.3 ± 5.9 | − 9.3, − 25.3 to 6.6 | 144.1 ± 8.7 | 0.2, − 23.0 to 23.4 | − 14.8 | − 35.7 to 6.0 | |
VLDL large (nmol/L) | Baseline | 23.9 ± 1.0 | 22.2 ± 1.7 | 1.7 | − 2.3 to 5.7 | ||
1 year | 19.1 ± 1.0 | − 4.8, − 7.6 to − 2.0* | 22.7 ± 1.8 | 0.5, − 4.3 to 5.2 | − 3.6 | − 7.7 to 0.6 | |
2 years | 20.3 ± 1.0 | − 3.6, − 6.4 to − 0.8 | 21.9 ± 1.7 | − 0.3, − 5.0 to 4.4 | − 1.6 | − 5.7 to 2.4 | |
VLDL medium (nmol/L) | Baseline | 57.3 ± 1.8 | 55.2 ± 3.1 | 2.1 | − 5.2 to 9.3 | ||
1 year | 52.3 ± 1.8 | − 5.0, − 10.0 to 0.0 | 54.6 ± 3.2 | − 0.5, − 9.1 to 8.0 | − 2.4 | − 9.8 to 5.1 | |
2 years | 52.5 ± 1.8 | − 4.7, − 9.7 to 0.3 | 54.7 ± 3.1 | − 0.5, − 8.9 to 7.9 | − 2.2 | − 9.4 to 5.1 | |
VLDL small (nmol/L) | Baseline | 59.3 ± 1.5 | 55.8 ± 2.6 | 3.4 | − 2.6 to 9.5 | ||
1 year | 63.2 ± 1.5 | 3.9, − 0.3 to 8.1 | 55.0 ± 2.7 | − 0.8, − 8.0 to 6.3 | 8.2 | 2.0 to 14.4 | |
2 years | 59.2 ± 1.5 | − 0.1, − 4.3 to 4.1 | 54.9 ± 2.6 | − 0.9, − 8.0 to 6.1 | 4.3 | − 1.8 to 10.4 | |
Total IDL (nmol/L) | Baseline | 256.6 ± 8.0 | 255.1 ± 11.9 | 1.6 | − 27.0 to 30.1 | ||
1 year | 285.1 ± 8.3 | 28.4, 5.9 to 50.9 | 256.1 ± 12.3 | 1.1, − 32.0 to 34.1 | 28.9 | − 0.6 to 58.4 | |
2 years | 288.9 ± 8.4 | 32.2, 9.6 to 54.9 Ï | 261.5 ± 12.3 | 6.4, − 26.5 to 39.4 | 27.3 | − 2.3 to 57.0 | |
IDL 1 (nmol/L) | Baseline | 136.2 ± 3.3 | 129.2 ± 5.7 | 7.0 | − 6.2 to 20.1 | ||
1 year | 139.4 ± 3.3 | 3.2, − 5.9 to 12.3 | 128.8 ± 5.9 | − 0.4, − 15.9 to 15.0 | 10.6 | − 2.9 to 24.1 | |
2 years | 136.4 ± 3.3 | 0.2, − 8.9 to 9.2 | 128.3 ± 5.7 | − 0.9, − 16.1 to 14.3 | 8.0 | − 5.1 to 21.1 | |
IDL 2 (nmol/L) | Baseline | 122.1 ± 3.8 | 113.3 ± 6.5 | 8.8 | − 6.3 to 23.8 | ||
1 year | 152.1 ± 3.8 | 30.0, 19.6 to 40.4* | 112.0 ± 6.7 | − 1.3, − 19.0 to 16.4 | 40.1* | 24.6 to 55.5* | |
2 years | 156.3 ± 3.8 | 34.2, 23.9 to 44.6* | 114.0 ± 6.5 | 0.7, − 16.7 to 18.1 | 42.3* | 27.2 to 57.3* | |
Total LDL (nmol/L) | Baseline | 991.8 ± 25.9 | 1028.7 ± 40.8 | − 36.9 | − 132.7 to 58.9 | ||
1 year | 962.7 ± 26.8 | − 29.1, − 101.9 to 43.7 | 1026.5 ± 43.1 | − 2.2, − 117.2 to 112.8 | − 63.8 | − 164.4 to 36.8 | |
2 years | 1002.0 ± 27.0 | 10.3, − 62.8 to 83.4 | 1022.1 ± 42.3 | − 6.6, − 120.2 to 107.0 | − 20.0 | − 119.6 to 79.6 | |
LDL I (nmol/L) | Baseline | 163.5 ± 6.0 | 155.6 ± 10.3 | 7.9 | − 16.0 to 31.8 | ||
1 year | 207.7 ± 6.1 | 44.2, 27.6 to 60.7* | 146.1 ± 10.7 | − 9.6, − 37.7 to 18.6 | 61.7* | 37.1 to 86.2* | |
2 years | 211.1 ± 6.0 | 47.6, 31.1 to 64.0* | 152.9 ± 10.3 | − 2.8, − 30.4 to 24.9 | 58.2* | 34.3 to 82.1* | |
LDL IIa (nmol/L) | Baseline | 137.8 ± 4.7 | 135.8 ± 8.0 | 2.0 | − 16.6 to 20.5 | ||
1 year | 153.4 ± 4.7 | 15.6, 2.7 to 28.4 | 126.5 ± 8.3 | − 9.3, − 31.1 to 12.5 | 26.9 | 7.8 to 45.9 | |
2 years | 156.1 ± 4.7 | 18.3, 5.5 to 31.1 Ï | 129.2 ± 8.0 | − 6.6, − 28.0 to 14.8 | 26.9Ï | 8.4 to 45.4Ï | |
LDL IIb (nmol/L) | Baseline | 176.0 ± 5.6 | 170.1 ± 9.5 | 6.0 | − 16.1 to 28.0 | ||
1 year | 169.7 ± 5.6 | − 6.3, − 21.6 to 9.0 | 166.0 ± 9.9 | − 4.1, − 30.0 to 21.9 | 3.7 | − 19.0 to 26.3 | |
2 years | 174.9 ± 5.6 | − 1.1, − 16.3 to 14.2 | 171.4 ± 9.5 | 1.3, − 24.3 to 26.9 | 3.6 | − 18.5 to 25.7 | |
LDL IIIa (nmol/L) | Baseline | 191.5 ± 7.3 | 169.8 ± 12.6 | 21.7 | − 7.4 to 50.8 | ||
1 year | 157.4 ± 7.4 | − 34.0, − 54.2 to − 13.9* | 187.2 ± 13.0 | 17.4, − 16.7 to 51.6 | − 29.8 | − 59.6 to 0.1 | |
2 years | 161.1 ± 7.3 | − 30.3, − 50.4 to − 10.3Ï | 193.5 ± 12.6 | 23.8, − 9.9 to 57.4 | − 32.4 | − 61.5 to − 3.3 | |
LDL IIIb (nmol/L) | Baseline | 87.8 ± 4.4 | 84.7 ± 7.6 | 3.1 | − 14.6 to 20.7 | ||
1 year | 66.5 ± 4.5 | − 21.2, − 33.5 to − 9.0* | 98.0 ± 7.9 | 13.3, − 7.5 to 34.1 | − 31.5* | − 49.6 to − 13.4* | |
2 years | 67.5 ± 4.4 | − 20.3, − 32.5 to − 8.1* | 96.5 ± 7.6 | 11.8, − 8.7 to 32.2 | − 29.0* | − 46.6 to − 11.3* | |
LDL IVa (nmol/L)a | Baseline | 89.1 ± 3.2 | 95.0 ± 5.6 | − 5.9 | − 18.7 to 6.9 | ||
1 year | 76.4 ± 3.2 | − 12.7, − 21.4 to − 4.0Ï | 93.1 ± 5.9 | − 1.9, − 17.4 to 13.6 | − 16.7 | − 30.0 to − 3.4 | |
2 years | 76.9 ± 3.2 | − 12.2, − 20.9 to − 3.6 | 89.9 ± 5.6 | − 5.1, − 20.2 to 10.1 | − 13.1 | − 25.9 to − 0.2 | |
LDL IVb (nmol/L)a | Baseline | 78.3 ± 1.8 | 82.8 ± 3.2 | − 4.5 | − 11.8 to 2.8 | ||
1 year | 71.6 ± 1.8 | − 6.7, − 11.7 to − 1.7 | 82.7 ± 3.3 | − 0.1, − 8.8 to 8.6 | − 11.1Ï | − 18.6 to − 3.6Ï | |
2 years | 73.2 ± 1.8 | − 5.1, − 10.1 to − 0.2 | 81.5 ± 3.2 | − 1.3, − 9.9 to 7.5 | − 8.3 | − 15.6 to − 1.0 | |
LDL IVc (nmol/L)a | Baseline | 88.9 ± 1.3 | 89.6 ± 2.2 | − 0.6 | − 5.8 to 4.5 | ||
1 year | 83.6 ± 1.3 | − 5.3, − 8.8 to − 1.7Ï | 88.6 ± 2.3 | − 0.9, − 7.1 to 5.2 | − 5.0 | − 10.3 to 0.3 | |
2 years | 84.0 ± 1.3 | − 5.0, − 8.5 to − 1.4 | 85.7 ± 2.2 | − 3.8, − 9.8 to 2.2 | − 1.8 | − 6.9 to 3.4 | |
Mid-zone (nmol/L) | Baseline | 875.3 ± 8.6 | 892.2 ± 14.7 | − 16.9 | − 50.9 to 17.1 | ||
1 year | 828.6 ± 8.6 | − 46.6, − 70.2 to − 23.1* | 890.5 ± 15.2 | − 1.7, − 41.8 to 38.3 | − 61.8* | − 96.7 to − 26.9* | |
2 years | 815.4 ± 8.6 | − 59.9, − 83.4 to − 36.4* | 876.0 ± 14.7 | − 16.2, − 55.6 to 23.2 | − 60.6* | − 94.6 to − 26.5* | |
Total HDL | Baseline | 22.9 ± 0.3 | 25.1 ± 0.5 | − 2.2 | − 3.4 to − 0.9 | ||
1 year | 22.8 ± 0.4 | − 0.2, − 1.1 to 0.8 | 24.8 ± 0.5 | − 0.3, − 1.7 to 1.1 | − 2.0 | − 3.3 to − 0.7 | |
2 years | 22.8 ± 0.4 | − 0.1, − 1.1 to 0.9 | 25.3 ± 0.5 | 0.2, − 1.2 to 1.6 | − 2.5 | − 3.8 to − 1.2 | |
HDL 2b (µmol/L) | Baseline | 6.0 ± 0.1 | 6.0 ± 0.1 | 0.0 | − 0.3 to 0.2 | ||
1 year | 6.3 ± 0.1 | 0.4, 0.1 to 0.6Ï | 6.0 ± 0.1 | − 0.0, − 0.4 to 0.4 | 0.3 | 0.0 to 0.7 | |
2 years | 6.3 ± 0.1 | 0.3, 0.1 to 0.5 | 6.1 ± 0.1 | 0.1, − 0.3 to 0.5 | − 0.1 | − 0.2 to 0.5 | |
HDL 2a + 3 (µmol/L) | Baseline | 17.3 ± 0.2 | 18.0 ± 0.3 | − 0.7 | − 1.3 to − 0.1 | ||
1 year | 16.8 ± 0.2 | − 0.5, − 0.9 to − 0.0 | 17.5 ± 0.3 | − 0.5, − 1.2 to 0.3 | − 0.7 | − 1.4 to − 0.0 | |
2 years | 17.0 ± 0.2 | − 0.3, − 0.8 to 0.1 | 17.8 ± 0.3 | − 0.2, − 0.9 to 0.6 | − 0.8 | − 1.5 to − 0.2 | |
LDL peak diameters (Å) | Baseline | 215.2 ± 0.5 | 215.0 ± 0.8 | 0.2 | − 1.7 to 2.1 | ||
1 year | 219.6 ± 0.5 | 4.4, 3.1 to 5.7* | 215.1 ± 0.8 | 0.1, − 2.1 to 2.3 | 4.5* | 2.6 to 6.5* | |
2 years | 219.5 ± 0.5 | 4.3, 3.0 to 5.6* | 215.8 ± 0.8 | 0.8, − 1.4 to 3.0 | 3.7* | 1.8 to 5.6* |