Depression and cardiovascular risk—association among Beck Depression Inventory, PCSK9 levels and insulin resistance

Table 3 Linear regression models to evaluate the association of PCSK9 levels with severity of depression (BDI-II score)

	β	SE	P-value
Univariate model
Intercept	249.98	9.85	<.0001
BDI-II Score (for unit increase)	2.75	0.68	<.0001
Adjusted model
Intercept	188.43	53.14	0.0004
BDI-II Score (for unit increase)	1.85	0.69	0.0074
Age, years	− 0.07	0.48	0.8824
Gender			0.0004
Male	− 46.10	12.86
Female	Ref
BMI	−0.29	1.00	0.7673
Smoking status			0.0157
Current smoker	21.29	15.67	0.1752
Former smoker	34.13	11.88	0.0043
Never smoker	Ref
Non-HDL, mg/dl	0.49	0.15	0.0015
Statin medications
Yes	63.35	21.22	0.0022
No	Ref
Triglyceride, mg/dl	0.07	0.08	0.3730
Antihypertensive medications
Yes	13.07	13.9	0.3479
No	Ref
Antidepressive medications
Yes	0.34	18.02	0.9848
No	Ref

BDI Beck Depression Inventory, BMI body mass index, HDL high-density lipoprotein, PCSK9 pro-protein convertase subtilisin/kexin type 9, Ref stands for reference value

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