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Table 2 Model performance

From: MR-proANP and incident cardiovascular disease in patients with type 2 diabetes with and without heart failure with preserved ejection fraction

 

C-statistics

Net reclassification index

p-value

MR-proANP

 Continuous variable (univariable)

0.66 (0.61–0.71)

  

 Cut-off 60 pmol/l (univariable)

0.57 (0.54–0.62)

  

Multivariable analyses

 Model 1

0.72 (0.68–0.78)

  

 Model 1 + MR-proANP (continuous)

0.74 (0.69–0.78)

27.1% (7.6–46.6)

0.007

 Model 1 + MR-proANP (Cut-off 60 pmol/l)

0.73 (0.68–0.77)

12.1% (-7.0–0.31)

0.22

Heart failure status

 Heart failure status (univariable)

0.63 (0.58–0.67)

  

 Model 1 + heart failure status

0.75 (0.71–0.80)

32.8% (13.5–52.0)

 < 0.001

  1. Model 1 includes age, sex, duration of diabetes, known CV disease, SBP > 170 mmHg, BMI and albuminuria
  2. The multivariable Cox proportional hazards model (Model 1) with NRI when adding MR-proANP as a continuous or dichomized variable or when adding heart failure status. For reference, the univariable Cox proportional hazards models with MR-proANP as a continuous or dichotomized variable, and with heart failure status are shown
  3. NRI, net reclassification index; MR-proANP, Mid-regional pro-atrial natriuretic peptide; CV, cardiovascular; SBP, systolic blood pressure; BMI, body mass index
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Cardiovascular Diabetology

ISSN: 1475-2840