Tertile 1 n = 2008 SBP 74–124 mmHg | Tertile 2 n = 1909 SBP > 124–136 mmHg | Tertile 3 n = 1935 SBP > 136–225 mmHg | P | |
---|---|---|---|---|
Age (years) | 57.9 ± 9.8 | 60.5 ± 9.3 | 62.6 ± 9.3 | < 0.001 |
Female, n (%) | 503 (25%) | 603 (32%) | 673 (35%) | < 0.001 |
Race, n (%) | < 0.001 | |||
Asian | 294 (15%) | 274 (14%) | 190 (10%) | |
Black or African American | 52 (3%) | 74 (4%) | 78 (4%) | |
White | 1444 (72%) | 1447 (76%) | 1517 (78%) | |
Other | 218 (11%) | 114 (6%) | 150 (8%) | |
Systolic blood pressure (mmHg) | 114 ± 8 | 130 ± 4 | 149 ± 11 | NA |
Diastolic blood pressure (mmHg) | 72 ± 7 | 79 ± 7 | 84 ± 9 | < 0.001 |
Pulse pressure (mmHg) | 42 ± 7 | 51 ± 7 | 65 ± 12 | NA |
Heart rate (bpm) | 71 ± 9 | 70 ± 9 | 70 ± 10 | 0.011 |
BMI (kg/m2) | 29.1 ± 5.3 | 30.4 ± 5.8 | 31.0 ± 5.8 | < 0.001 |
Diabetes duration (years) | 8.4 ± 8.0 | 9.2 ± 8.1 | 10.3 ± 9 | < 0.001 |
HbA1c (%) | 7.7 ± 1.3 | 7.7 ± 1.3 | 7.7 ± 1.3 | 0.33 |
eGFR (ml/min/1.73m2) | 78 ± 21 | 76 ± 21 | 74 ± 22 | < 0.001 |
Albuminuria (mg/g) | < 0.001 | |||
< 30 (normal) | 1637 (82%) | 1424 (75%) | 1269 (66%) | |
≥ 30–< 300 (micro) | 297 (15%) | 363 (19%) | 465 (24%) | |
≥ 300 (macro) | 67 (3%) | 117 (6%) | 191 (10%) | |
BNP (pg/ml) median [IQR] | 106 [49–234] | 100 [47–203] | 111 [54–226] | 0.006 |
Smoking status, n (%) | < 0.001 | |||
Current | 248 (12%) | 214 (11%) | 205 (11%) | |
Former | 1012 (50%) | 789 (41%) | 864 (45%) | |
Never | 748 (37%) | 906 (48%) | 866 (45%) | |
MI history other than index ACS, n (%) | 402 (20%) | 450 (24%) | 489 (25%) | < 0.001 |
Stroke history, n (%) | 73 (4%) | 106 (6%) | 135 (7%) | < 0.001 |
Heart failure history, n (%) | 436 (22%) | 469 (25%) | 412 (21%) | 0.030 |
Coronary revascularization history, n (%) | 1449 (72%) | 1241 (65%) | 1391 (72%) | < 0.001 |
STEMI at index event, n (%) | 1088 (54%) | 798 (42%) | 687 (36%) | < 0.001 |
Left ventricular ejection fractiona (percent) | 48 ± 13 | 52 ± 12 | 52 ± 11 | < 0.001 |
Insulin, n (%) | 733 (37%) | 729 (38%) | 819 (42%) | < 0.001 |
Statin, n (%) | 1889 (94%) | 1755 (92%) | 1788 (92%) | 0.024 |
Beta blocker, n (%) | 1691 (84%) | 1597 (84%) | 1665 (86%) | 0.10 |
Calcium channel blocker, n (%) | 224 (11%) | 428 (22%) | 629 (33%) | < 0.001 |
Diuretic, n (%) | 727 (36%) | 728 (38%) | 853 (44%) | < 0.001 |
ACE inhibitor, n (%) | 1233 (61%) | 1164 (61%) | 1135 (59%) | 0.17 |
ARB, n (%) | 418 (21%) | 503 (26%) | 634 (33%) | < 0.001 |
Alpha blocker, n (%) | 89 (4%) | 67 (4%) | 102 (5%) | 0.029 |
Potassium sparing agents, n (%) | 367 (18%) | 268 (14%) | 220 (11%) | < 0.001 |