Fig. 1

Association of HbA1c variability at week 28 (a) and 52 (b) and subsequent CV deaths (Landmark analysis) in the treatment groups separately. Only patients still at risk for CV death at week 28 (week 52, resp.) and with at least 2 post-baseline HbA1C measurements up to week 28 (week 52, resp.) included. HRs are for a 1-unit (%) increase in HbA1c variability. CV cardiovascular, HbA1c glycated hemoglobin, LM landmark. Cox models include: age, sex, Hba1c, BMI, eGFR, geographic region, treatment, change in HbA1c from baseline to week 12, HbA1c variability up to week 28 (week 52, resp.) and its interaction with treatment. *HbA1c variability*treatment interaction