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Table 2 Hazard ratios and 95% confidence intervals for myocardial infarction and stroke according to the cumulative number of individual metabolic syndrome components

From: Exposure-weighted scoring for metabolic syndrome and the risk of myocardial infarction and stroke: a nationwide population-based study

 

Myocardial Infarction

Stroke

Events (n)

Incidence ratea

Model 1

Model 2

Events (n)

Incidence ratea

Model 1

Model 2

MetS

0 (n = 1,651,616)

3714

0.51

1(ref.)

1(ref.)

3670

0.50

1(ref.)

1(ref.)

1 (n = 382,605)

1648

0.98

1.49 (1.41, 1.58)

1.40 (1.32, 1.49)

1688

1.01

1.44 (1.36, 1.52)

1.36 (1.28, 1.44)

2 (n = 224,351)

1298

1.32

1.84 (1.73, 1.96)

1.68 (1.57, 1.80)

1384

1.41

1.78 (1.67, 1.90)

1.64 (1.53, 1.75)

3 (n = 168,404)

1235

1.68

2.17 (2.04, 2.32)

1.95 (1.81, 2.09)

1281

1.74

1.99 (1.87, 2.12)

1.78 (1.66, 1.91)

4 (n = 217,875)

2627

2.76

3.28 (3.12, 3.46)

2.87 (2.70, 3.05)

2501

2.63

2.68 (2.55, 2.83)

2.30 (2.17, 2.45)

P for trend

  

< 0.0001

< 0.0001

  

< 0.0001

< 0.0001

BP

0 (n = 929,973)

1755

0.43

1(ref.)

1(ref.)

1507

0.37

1(ref.)

1(ref.)

1 (n = 517,955)

1431

0.63

1.23 (1.15, 1.32)

1.19 (1.11, 1.28)

1207

0.53

1.17 (1.09, 1.27)

1.10 (1.02, 1.19)

2 (n = 375,277)

1334

0.81

1.44 (1.34, 1.55)

1.36 (1.27, 1.47)

1347

0.82

1.58 (1.47, 1.71)

1.41 (1.30, 1.52)

3 (n = 301,057)

1400

1.06

1.74 (1.62, 1.87)

1.61 (1.49, 1.74)

1546

1.17

2.00 (1.86, 2.15)

1.70 (1.57, 1.83)

4 (n = 520,589)

4602

2.02

2.64 (2.49, 2.80)

2.37 (2.21, 2.53)

4917

2.16

2.66 (2.50, 2.82)

2.16 (2.02, 2.32)

P for trend

  

< 0.0001

< 0.0001

  

< 0.0001

< 0.0001

WC

0 (n = 1,890,155)

6319

0.76

1(ref.)

1(ref.)

6337

0.76

1(ref.)

1(ref.)

1 (n = 270,543)

1292

1.09

1.24 (1.17, 1.32)

1.12 (1.05, 1.19)

1318

1.11

1.20 (1.13, 1.27)

1.10 (1.04, 1.17)

2 (n = 157,263)

839

1.22

1.32 (1.22, 1.41)

1.14 (1.06, 1.23)

846

1.23

1.24 (1.16, 1.34)

1.11 (1.03, 1.19)

3 (n = 135,252)

782

1.32

1.39 (1.29, 1.50)

1.17 (1.09, 1.26)

793

1.34

1.32 (1.23, 1.42)

1.14 (1.06, 1.23)

4 (n = 191,638)

1290

1.54

1.61 (1.52, 1.71)

1.29 (1.21, 1.37)

1230

1.47

1.45 (1.36, 1.54)

1.19 (1.11, 1.26)

P for trend

  

< 0.0001

< 0.0001

  

< 0.0001

< 0.0001

Fasting glucose

0 (n = 1,192,187)

3214

0.61

1(ref.)

1(ref.)

3026

0.57

1(ref.)

1(ref.)

1 (n = 610,969)

2210

0.82

1.10 (1.04, 1.16)

1.03 (0.97, 1.09)

2153

0.80

1.09 (1.03, 1.16)

1.01 (0.96, 1.07)

2 (n = 348,772)

1571

1.03

1.20 (1.13, 1.28)

1.07 (1.00, 1.14)

1548

1.01

1.16 (1.09, 1.24)

1.02 (0.95, 1.08)

3 (n = 223,765)

1194

1.22

1.27 (1.19, 1.36)

1.06 (0.99, 1.14)

1214

1.24

1.22 (1.14, 1.31)

0.99 (0.93, 1.07)

4 (n = 269,158)

2333

1.99

1.73 (1.64, 1.83)

1.28 (1.19, 1.37)

2583

2.20

1.73 (1.64, 1.83)

1.22 (1.14, 1.30)

P for trend

  

< 0.0001

< 0.0001

  

< 0.0001

< 0.0001

Triglycerides

0 (n = 1,177,953)

2624

0.50

1(ref.)

1(ref.)

2866

0.55

1(ref.)

1(ref.)

1 (n = 454,920)

1579

0.79

1.32 (1.24, 1.41)

1.32 (1.24, 1.41)

1631

0.81

1.24 (1.17, 1.32)

1.26 (1.18, 1.34)

2 (n = 315,637)

1441

1.04

1.60 (1.50, 1.70)

1.60 (1.49, 1.71)

1430

1.03

1.42 (1.34, 1.52)

1.46 (1.36, 1.56)

3 (n = 281,844)

1434

1.16

1.70 (1.59, 1.81)

1.71 (1.59, 1.84)

1493

1.21

1.59 (1.49, 1.69)

1.64 (1.53, 1.76)

4 (n = 414,497)

3444

1.90

2.61 (2.48, 2.75)

2.61 (2.44, 2.79)

3104

1.71

2.09 (1.99, 2.20)

2.16 (2.02, 2.30)

P for trend

  

< 0.0001

< 0.0001

  

< 0.0001

< 0.0001

HDL-C

0 (n = 1,679,086)

4486

0.61

1(ref.)

1(ref.)

4740

0.64

1(ref.)

1(ref.)

1 (n = 380,468)

1652

0.99

1.49 (1.41, 1.57)

1.44 (1.36, 1.53)

1615

0.97

1.33 (1.26, 1.41)

1.33 (1.26, 1.41)

2 (n = 212,105)

1170

1.25

1.76 (1.65, 1.88)

1.68 (1.57, 1.80)

1117

1.20

1.50 (1.40, 1.60)

1.49 (1.39, 1.59)

3 (n = 154,983)

992

1.46

1.97 (1.84, 2.11)

1.86 (1.73, 2.00)

989

1.45

1.73 (1.61, 1.85)

1.71 (1.59, 1.84)

4 (n = 218,209)

2222

2.32

2.84 (2.70, 2.99)

2.61 (2.47, 2.76)

2063

2.15

2.28 (2.17, 2.41)

2.18 (2.06, 2.30)

P for trend

  

< 0.0001

< 0.0001

  

< 0.0001

< 0.0001

  1. a per 1 000 person-years
  2. Model 1: Adjusted for age, sex, alcohol consumption, smoking, regular exercise, income status
  3. Model 2: Adjusted for model 1 + baseline systolic blood pressure, waist circumference, fasting glucose, triglyceride and high-density lipoprotein-cholesterol levels
  4. BP blood pressure, HDL-C high-density lipoprotein-cholesterol, MetS metabolic syndrome, WC waist circumference
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Cardiovascular Diabetology

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