Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007–2017

Einarson, Thomas R.; Acs, Annabel; Ludwig, Craig; Panton, Ulrik H.

doi:10.1186/s12933-018-0728-6

Cardiovascular Diabetology

Table 5 Mortality associated with cardiovascular disease in persons with type 2 diabetes

From: Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007–2017

Disease	Author (year)	Data collection period	Patients	n	All deaths	%	CVD Deaths	% Death rate	% CVD proportion of all deaths
CVD	Alwalkeel (2008) [30]	Jan 1989–Jan 2004	T2DM adults	1952	161	8.20%	97	5.00%	60.20%
CVD	Cardoso (2008) [31]	1994–96 to 2001	T2DM adults	471	121	25.70%	44	9.30%	36.40%
CVD	Carnethon (2010) [32]	1989–93 to 2005	T2DM only	659	468	71.00%	211	32.0%	45.10%
CVD	Carnethon (2010) [32]	1989–93 to 2005	CVD only	868	620	71.40%	304	35.0%	49.00%
CVD	Carnethon (2010) [32]	1989–93 to 2005	T2DM + CVD	260	219	84.20%	129	49.60%	58.90%
CVD	Carnethon (2010) [32]	1989–93 to 2005	No T2DM or CVD	3997	2095	52.40%	710	17.8%	33.90%
CVD	Eeg-Olofsson (2010) [33]	1997–98 to 2003	T2DM adults	18,334	1902	10.40%	1456	7.90%	76.60%
CVD	Malik (2015) [34]	2005–2011	T2DM adults	121,523	17,637	14.50%	3722	3.10%	21.10%
CVD	Menzaghi (2014) [36]	2001–2008	GHS study—males	242	NR	–	42	17.40%	–
CVD	Menzaghi (2014) [36]	2001–2008	GHS study—females	117	NR	–	16	13.70%	–
CVD	Menzaghi (2014) [36]	1993–1999	HPFS study—males	833	NR	–	146	17.50%	–
CVD	Menzaghi (2014) [36]	1976–1990	NMS study—females	902	NR	–	144	16.00%	–
CVD	Salinero-Fort (2016) [35]	2007–08 to 2012	T2DM adults	2442	203	8.30%	96	3.90%	47.30%
CVD	Salinero-Fort (2016) [35]	2007–08 to 2012	T2DM adults + kidney disease	965	221	22.90%	124	12.80%	56.10%
CVD	Shestakova (2016) [29]	2015	T2DM adults	3,060,516	66,093	2.20%	30,560	1.00%	46.20%
	All CVD death		Patients with T2DM	3,208,557	86,557^a	42.3%^a	36,576^a	9.9%^a	50.3%^a
CAD	Cardoso (2008) [31]	1994–1996 to 2001	T2DM adults	471	121	25.70%	30	6.40%	24.80%
CAD	Carnethon (2010) [32]	1989–1993 to 2005	T2DM only	659	468	71.00%	132	20.00%	28.20%
CAD	Carnethon (2010) [32]	1989–1993 to 2005	CVD only	868	620	71.40%	213	24.50%	34.40%
CAD	Carnethon (2010) [32]	1989–1993 to 2005	T2DM + CVD	260	219	84.20%	111	42.70%	50.70%
CAD	Carnethon (2010) [32]	1989–1993 to 2005	No T2DM or CVD	3997	2095	52.40%	425	10.60%	20.30%
CAD	Jackson (2012) [97]	2001–2007	Male diabetics	116,145	22,033	19.00%	6000	5.20%	27.20%
CAD	Jackson (2012) [97]	2001–2007	Male non-diabetics	2,433,748			36,801	1.50%
CAD	Jackson (2012) [97]	2001–2007	Female diabetics	100,507	20,571	20.50%	4554	4.50%	22.10%
CAD	Jackson (2012) [97]	2001–2007	Female non-diabetics	2,630,482			32,449	1.20%
	All CAD death		Patients with T2DM	218,462^a	42,944^a	24.9%^a	10,695^a	6.3%^a	29.7%^a
CHF	Mazza (2007) [104]	1983–1985 to 1997	Male diabetics	202	–	–	22	10.90%	–
CHF	Mazza (2007) [104]	1983–1985 to 1997	Female diabetics	379	–	–	29	7.70%	–
CHF	Mazza (2007) [104]	1983–1985 to 1997	All	581	369	63.50%	–	–	13.80%
CHF	Shestakova (2016) [29]	2015	T2DM adults	3,060,516	66,093	2.20%	18,963	0.60%	28.70%
	All CHF deaths		Patients with T2DM	3,061,097^a	66,093^a	2.2%^a	1,9104^a	6.1%^a	28.7%^a
MI	Shestakova (2016) [29]	2015	T2DM adults	3,060,516	66,093	2.20%	3393	0.10%	5.10%
SCD	Kucharska-Newton (2010) [99]	1987–89 to 2001	T2DM adults	1550	NR	–	69	4.50%	–
SCD	Kucharska-Newton (2010) [99]	1987–89 to 2001	No T2DM	12,428	NR	–	140	1.10%	–
Stroke	Jackson (2012) [97]	2001–2007	Male diabetics	116,145	22,033	19.00%	1942	1.70%	8.80%
Stroke	Jackson (2012) [97]	2001–2007	Male non-diabetics	2,433,748			13,191	0.50%
Stroke	Jackson (2012) [97]	2001–2007	Female diabetics	100,507	20,571	20.50%	2436	2.40%	11.80%
Stroke	Jackson (2012) [97]	2001–2007	Female non-diabetics	2,630,482			23,632	0.90%
Stroke	Shestakova (2016) [29]	2015	T2DM adults	3,060,516	66,093	2.20%	8204	0.30%	12.40%
	All CBV deaths		Patients with T2DM	327,168^a	108,697^a	3.30%	12,582^a	1.50%	11.0%^a

CAD coronary artery disease (variously reported as coronary heart disease or ischemic heart disease), CBV cerebrovascular disease, CHF congestive heart failure (also reported simply as heart failure), CVD cardiovascular disease, MI myocardial infarction, NR not reported, SCD sudden cardiac death, T2DM type 2 diabetes mellitus
^aWeighted average of rates taken only for patients with T2DM and where complete outcomes were reported; thus, the number does not represent the sum of all of the numbers in the column above it

Back to article page

ISSN: 1475-2840

Contact us

Submission enquiries: journalsubmissions@springernature.com