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Fig. 1 | Cardiovascular Diabetology

Fig. 1

From: Circulating interleukin-1β promotes endoplasmic reticulum stress-induced myocytes apoptosis in diabetic cardiomyopathy via interleukin-1 receptor-associated kinase-2

Fig. 1

A The right side of A demonstrated immunoblots of IRAK-2 and GAPDH in protein extracted from cardiac tissue from control rats, DCM rats, DCM rats received IL-1Ra administration at dosages of 1.0, 5.0, 7.5, 10.0 and 15.0 mg/Kg respectively daily for 1 week. Columns on the right part indicated the relative expression levels of IRAK-2 [hash differences were significant when compared with control rats (p < 0.05); asterisk differences were significant when compared with previous dosages (p < 0.05)]. B demonstrated the immunoblots of IL-1β, GRP-78, IRAK-2, CHOP and GAPDH in myocardial tissue in Ctrl, DCM and DCM + IL-1Ra respectively. Columns on the right side indicated the relative expression levels of IL-1β, GRP-78, IRAK-2 and CHOP (normalized to GAPDH) respectively. C Captured images demonstrated TUNEL staining in myocardial tissue harvested from Ctrl, DCM and DCM + IL-1Ra respectively. The red arrows are pointing at TUNEL-positive cells. Columns on the right side indicated the percentage of TUNEL-positive cells in Ctrl, DCM and DCM + IL-1Ra respectively [letter a differences were significant compared with Ctrl (p < 0.05); letter b differences were significant when compared with DCM (p < 0.05)]

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Cardiovascular Diabetology

ISSN: 1475-2840